Effects of silencing RIP1 with siRNA on the biological behavior of the LoVo human colon cancer cell line.

abstract：:This study was designed to explore the expression of phosphoinositide-dependent protein kinase 1 (PDK-1), deleted in malignant brain tumors (DMBT1) in the thyroid carcinoma. A total of 87 fresh samples of thyroid carcinoma from surgical resection in The Second People's Hospital of Lianyungang from June 2016 to March 2...

journal_title：Oncology letters

authors： Sun Z,Xu L

更新日期：2019-09-01 00:00:00

abstract：:In the present study, the effect of immunophenotyping on the prognoses of patients with multiple myeloma (MM) treated with bortezomib plus dexamethasone was investigated. The study involved 46 patients with MM, and analyzed the prognostic significance of the expression of cluster of differentiation (CD)45, CD56 and ma...

journal_title：Oncology letters

authors： Iriyama N,Miura K,Hatta Y,Kobayashi S,Uchino Y,Kurita D,Sakagami H,Takahashi H,Sakagami M,Kobayashi Y,Nakagawa M,Ohtake S,Iizuka Y,Takei M

更新日期：2017-05-01 00:00:00

abstract：:Retroperitoneal tumors are lesions with diverse pathological subtypes that originate from the retroperitoneal space; ~40% of these tumors are benign. Due to such lesions often surrounding and associating with vital abdominal blood vessels, a complete surgical resection is difficult. The current study presents a novel ...

journal_title：Oncology letters

authors： Wan Z,Yin T,Chen H,Li D

更新日期：2016-05-01 00:00:00

abstract：:Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...

journal_title：Oncology letters

authors： Zeng C,Wen M,Liu X

更新日期：2018-04-01 00:00:00

abstract：:The talin proteins are a key component of the extracellular matrix-integrin-cytoskeleton system, and our previous study suggested that talin2 contributes to the tumor invasion and metastasis processes regulated by the tumor microenvironment. In the present study, the specific effects of talin2 on the invasive ability ...

journal_title：Oncology letters

authors： Wen Z,Liang Y,Deng S,Zou L,Xie X,Yang J,Wu Y

更新日期：2019-06-01 00:00:00

abstract：:The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...

journal_title：Oncology letters

authors： Shan XY,Xu TT,Liu ZL,Hu XF,Zhang YD,Guo SZ,Wang B

更新日期：2017-08-01 00:00:00

abstract：:Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...

journal_title：Oncology letters

authors： Togashi Y,Masago K,Ito Y,Sakamori Y,Okuda C,Fukuhara A,Nagai H,Kim YH,Mishima M

更新日期：2013-02-01 00:00:00

abstract：:The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...

journal_title：Oncology letters

authors： Yu J,Zhang H,Sun S,Sun S,Li L

更新日期：2019-02-01 00:00:00

abstract：:Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...

journal_title：Oncology letters

authors： Jiang M,Zhuang Y,Zu WC,Jiao L,Richard SA,Zhang S

更新日期：2019-06-01 00:00:00

abstract：:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

journal_title：Oncology letters

authors： Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

更新日期：2018-08-01 00:00:00

abstract：:Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...

journal_title：Oncology letters

authors： Gong Z,Zhang Y,Chu H,Lian P,Zhang L,Sun P,Chen J

更新日期：2014-11-01 00:00:00

abstract：:In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...

journal_title：Oncology letters

authors： Deng H,Zhen H,Fu Z,Huang X,Zhou H,Liu L

更新日期：2012-01-01 00:00:00

abstract：:Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...

journal_title：Oncology letters

authors： Takesue T,Kawakubo H,Hayashida T,Tsutsui M,Miyao K,Fukuda K,Nakamura R,Takahashi T,Wada N,Takeuchi H,Kitagawa Y

更新日期：2017-10-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated ...

journal_title：Oncology letters

authors： Zhou N,Lu F,Liu C,Xu K,Huang J,Yu D,Bi L

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...

journal_title：Oncology letters

authors： Yan J,Wen J,Wei ZD,Li XS,Li P,Xiao SW

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...

journal_title：Oncology letters

authors： Chen Z,Xiao HE,Ramchandra P,Huang HJ

更新日期：2014-04-01 00:00:00

abstract：:MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell pro...

journal_title：Oncology letters

authors： Hou Y

更新日期：2019-01-01 00:00:00

abstract：:Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...

journal_title：Oncology letters

authors： Futamura N,Urakawa H,Tsukushi S,Arai E,Kozawa E,Ishiguro N,Nishida Y

更新日期：2016-04-01 00:00:00

abstract：:The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...

journal_title：Oncology letters

authors： Zhao W,Xu H

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...

journal_title：Oncology letters

authors： Tang H,Kong Y,Si L,Cui C,Sheng X,Chi Z,Dai J,Yu S,Ma M,Wu X,Yu J,Xu T,Yu H,Yan J,Guo J

更新日期：2018-02-01 00:00:00

abstract：:The downregulation of farnesoid X receptor (FXR; gene name, nuclear receptor subfamily 1 group h member 4), an enteric nuclear bile acid receptor, has been reported in colorectal carcinoma (CRC), and FXR expression has been inversely correlated with CRC stage and clinical outcome. FXR knockdown in chronic colitis mous...

journal_title：Oncology letters

authors： Mao J,Chen X,Wang C,Li W,Li J

更新日期：2020-07-01 00:00:00

abstract：:Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...

journal_title：Oncology letters

authors： Hong R,Lee G,Kim H,Kim CS,Kee KH

更新日期：2012-03-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy affecting pediatric and adult populations. Although the outcomes of ALL in children have improved markedly in previous years, limited treatment strategies are available at present for adult patients with ALL. Wee1 is a crucial cell cycle checkp...

journal_title：Oncology letters

authors： Duan Y,Dong X,Nie J,Li P,Lu F,Ma D,Ji C

更新日期：2018-10-01 00:00:00

abstract：:The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...

journal_title：Oncology letters

authors： Lu J,Tan H,Li B,Chen S,Xu L,Zou Y

更新日期：2020-01-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B-cell development and B-cell tumorigenesis remains poorly understood. By analy...

journal_title：Oncology letters

authors： Zhang W,He X,Hu J,Yang P,Liu C,Wang J,An R,Zhen J,Pang M,Hu K,Ke X,Zhang X,Jing H

更新日期：2019-10-01 00:00:00

abstract：:Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...

journal_title：Oncology letters

authors： Liu H,Li Y,Li J,Liu Y,Cui B

更新日期：2018-08-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To the best of our knowledge, the function and regulatory role of miR-532-5p in human CRC remains unknown. The aim of the present study was to determine the role and regulation of miR-532-5p in CRC. ...

journal_title：Oncology letters

authors： Zhang J,Zhou W,Liu Y,Liu T,Li C,Wang L

更新日期：2018-05-01 00:00:00

abstract：:The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probe...

journal_title：Oncology letters

authors： Ke Z,Lai Y,Ma X,Lil S,Huang W

更新日期：2014-02-01 00:00:00

abstract：:The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expres...

journal_title：Oncology letters

authors： Kim HS,Hwang IG,Min HY,Bang YJ,Kim WH

更新日期：2019-05-01 00:00:00

abstract：:Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and t...

journal_title：Oncology letters

authors： Ning J,Guo X,Wang N,Xue L

更新日期：2015-11-01 00:00:00