A potential novel therapy for FGFR1-amplified pancreatic cancer with bone metastasis, screened by next-generation sequencing and a patient-derived xenograft model.

abstract：:Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...

journal_title：Oncology letters

authors： Yang C,Yan J,Yuan G,Zhang Y,Lu D,Ren M,Cui W

更新日期：2014-09-01 00:00:00

abstract：:Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...

journal_title：Oncology letters

authors： Futamura N,Urakawa H,Tsukushi S,Arai E,Kozawa E,Ishiguro N,Nishida Y

更新日期：2016-04-01 00:00:00

abstract：:Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine-platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 201...

journal_title：Oncology letters

authors： Dano D,Delteil C,Boissier R,Delaporte V,Habert P,Salas S,Duffaud F,Deville JL

更新日期：2019-03-01 00:00:00

abstract：:Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second ...

journal_title：Oncology letters

authors： Liu Z,Li Y,Luo Q

更新日期：2018-11-01 00:00:00

abstract：:The purpose of the present study was to explore the targets of forkhead box D3 (FOXD3) in lung cancer, and thus contribute to the diagnosis and therapy of the disease. The gene expression profile of GSE64513 was downloaded from the Gene Expression Omnibus database. The dataset contained 3 FOXD3 knockout A549 lung canc...

journal_title：Oncology letters

authors： Jiang W,Liu P,Li X

更新日期：2018-03-01 00:00:00

abstract：:Xeroderma pigmentosum variant (XP-V) is a subtype of xeroderma pigmentosum (XP) disease with typical pigmentation and types of cancer in the oral maxillofacial and other sun-exposed regions. Few factors of tumor proneness in XP-V have been completely elucidated with the exception of the POLH [which encodes DNA polymer...

journal_title：Oncology letters

authors： Guo J,Zhou G,Zhang W,Song Y,Bian Z

更新日期：2013-12-01 00:00:00

abstract：:The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...

journal_title：Oncology letters

authors： Wang N,Wang K,Zhong D,Liu X,Sun JI,Lin L,Ge L,Yang BO

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification w...

journal_title：Oncology letters

authors： Huang JX,Zhao K,Lin M,Wang Q,Xiao W,Lin MS,Yu H,Chen P,Qian RY

更新日期：2013-07-01 00:00:00

abstract：:Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...

journal_title：Oncology letters

authors： Elsayad K,Kriz J,Bauch J,Scobioala S,Haverkamp U,Sunderkötter C,Eich HT

更新日期：2015-05-01 00:00:00

abstract：:Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...

journal_title：Oncology letters

authors： Lin M,Li Y,Qin S,Jiao Y,Hua F

更新日期：2020-04-01 00:00:00

abstract：:The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was deter...

journal_title：Oncology letters

authors： Zhang S,Lei R,Wu J,Shan J,Hu Z,Chen L,Ren X,Yao L,Wang J,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00

abstract：:The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...

journal_title：Oncology letters

authors： Cao F,Li A,Li J,Fang YU,Li F

更新日期：2015-10-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

journal_title：Oncology letters

authors： He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB....

journal_title：Oncology letters

authors： Shen ZY,Liu C,Wu MF,Shi HF,Zhou YF,Zhuang W,Xia GL

更新日期：2017-09-01 00:00:00

abstract：:Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...

journal_title：Oncology letters

authors： Nishihara K,Suekane S,Ueda K,Nakiri M,Matsuo M,Igawa T

更新日期：2019-06-01 00:00:00

abstract：:Gastric cancer is one of leading causes of cancer-related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern tech...

journal_title：Oncology letters

authors： Jin Z,Jiang W,Wang L

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...

journal_title：Oncology letters

authors： Chen Z,Xiao HE,Ramchandra P,Huang HJ

更新日期：2014-04-01 00:00:00

abstract：:Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...

journal_title：Oncology letters

authors： Lu K,Shen H,Zhu S,Bi S,Wu S

更新日期：2018-08-01 00:00:00

abstract：:Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient u...

journal_title：Oncology letters

authors： Chen J,Yang S,Chen J,Liao T,Deng W,Li W

更新日期：2016-04-01 00:00:00

abstract：:The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were p...

journal_title：Oncology letters

authors： Huang J,Chen H,Wei Q,Zhang Z,Zhong Z,Xu Y

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...

journal_title：Oncology letters

authors： Zhou G,Liu X,Xiong B,Sun Y

更新日期：2017-10-01 00:00:00

abstract：:The present study examined the association between squamous cell carcinoma antigen (SCCA) expression and the response of patients with cervical cancer to docetaxel-carboplatin (DC) combination chemotherapy, in order to determine the prognostic potential of SCCA expression. A total of 21 patients were enrolled with sta...

journal_title：Oncology letters

authors： Chen P,Jiao L,Wang DB

更新日期：2017-03-01 00:00:00

abstract：:The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...

journal_title：Oncology letters

authors： Zhang L,Xu B,Wang Y,Liu C,Lu K,Huang Y,Liu N,Zhang X,Chen S,Chen M

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between Girdin and PI3K in breast cancer stem cells and the clinical implications of the co-expression of these two proteins in breast cancer patients. CD44+/CD24- tumor cells from the MD-231 cell line were sorted by flow cytometry. The expression status of Gird...

journal_title：Oncology letters

authors： Jin F,Liu C,Guo Y,Chen H,Wu Y

更新日期：2013-05-01 00:00:00

abstract：:The molecular profile of low-grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low-grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP-2, MMP-7 and MMP-9 was detected by immunohistochemistry in a coho...

journal_title：Oncology letters

authors： Fan J,Wu FY,Wang L,Jiang GN,Gao W

更新日期：2011-11-01 00:00:00

abstract：:Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases....

journal_title：Oncology letters

authors： Cui Y,Mao Z,Liao C

更新日期：2015-01-01 00:00:00

abstract：:Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

journal_title：Oncology letters

authors： Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

更新日期：2017-07-01 00:00:00

abstract：:The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...

journal_title：Oncology letters

authors： Dong S,Zhang P,Liang S,Wang S,Sun P,Wang Y

更新日期：2013-12-01 00:00:00