Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma.

abstract：:Although previous studies have demonstrated that Glut-1 is the predominant glucose transporter, is significantly overexpressed in various types of tumor and is correlated with poor prognosis, the potential function and clinical value of Glut-1 expression in osteosarcoma remains largely unclear. In particular, the pros...

journal_title：Oncology letters

authors： Fan J,Mei J,Zhang MZ,Yuan F,Li SZ,Yu GR,Chen LH,Tang Q,Xian CJ

更新日期：2017-08-01 00:00:00

abstract：:Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...

journal_title：Oncology letters

authors： Cheng L,Shi G,Fang C,Li G,Zheng Y,Chen W

更新日期：2019-03-01 00:00:00

abstract：:Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Pre...

journal_title：Oncology letters

authors： Ju X,Huang P,Chen M,Wang Q

更新日期：2017-12-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be closely correlated with the development and progression of tumors, as well as with chemo- and radioresistance. Targeting CSCs may therefore be a promising potential strategy for the treatment of cancer. Currently, natural products have received great interest due to their th...

journal_title：Oncology letters

authors： Sun G,Wei L,Feng J,Lin J,Peng J

更新日期：2016-06-01 00:00:00

abstract：:The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines...

journal_title：Oncology letters

authors： Indrová M,Rossowska J,Pajtasz-Piasecka E,Mikyšková R,Richter J,Rosina J,Sedlacek R,Fišerová A

更新日期：2018-03-01 00:00:00

abstract：:The present study designed a novel preoperative chemoradiotherapy (CRT) with sequential oxaliplatin and irinotecan with S-1 for locally advanced rectal cancer (LARC). This phase I study evaluated the maximum tolerated dose and recommended dose (RD) of oxaliplatin following irinotecan with S-1. Patients with clinical s...

journal_title：Oncology letters

authors： Fujikawa H,Toiyama Y,Inoue Y,Omura Y,Ide S,Kitajima T,Yasuda H,Okugawa Y,Okita Y,Yoshiyama S,Hiro J,Kobayashi M,Ohi M,Araki T,Kusunoki M

更新日期：2019-04-01 00:00:00

abstract：:Scalp angiosarcoma is a rare, extremely aggressive cutaneous malignancy with poor patient prognosis. The present study reviewed the cases of 42 patients who presented scalp angiosarcoma and were treated at the Zhongshan Hospital of Fudan University between January 2002 and December 2013. The clinical characteristics, ...

journal_title：Oncology letters

authors： Zhang Y,Yan Y,Zhu M,Chen C,Lu N,Qi F,Liu J

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...

journal_title：Oncology letters

authors： Zhang Q,Nong J,Wang J,Yan Z,Yi L,Gao X,Liu Z,Zhang H,Zhang S

更新日期：2019-04-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...

journal_title：Oncology letters

authors： Jiang B,Shi W,Li P,Wu Y,Li Y,Bao C

更新日期：2021-01-01 00:00:00

abstract：:The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benig...

journal_title：Oncology letters

authors： Hong LZ,Wei XW,Chen JF,Shi Y

更新日期：2013-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. Wnt family member 10A (Wnt10a) is an oncogene associated with the carcinogenesis and progression of renal cell carcinoma, and is strongly expressed in the CRC cell line SW480. However, the role of Wnt10a in CRC has been rarely...

journal_title：Oncology letters

authors： Li J,Zhang Z,Wang L,Zhang Y

更新日期：2019-04-01 00:00:00

abstract：:Mosquito coils, which are commonly used as residential insecticides in Asia, contain different concentrations of octachlorodipropyl ether (S-2) as a synergist or an active ingredient. As bis(chloromethyl) ether (BCME) is an extremely potent lung carcinogen that can be produced by the thermolytic degradation of S-2, co...

journal_title：Oncology letters

authors： Zhang J,Qi HW,Sun YP,Xie HK,Zhou CC

更新日期：2015-04-01 00:00:00

abstract：:The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DN...

journal_title：Oncology letters

authors： Wang X,Wang H,Bu R,Fei X,Zhao C,Song Y

更新日期：2012-08-01 00:00:00

abstract：:Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it unsuitable for operative surgery, and resistant to chemotherapy and radiation therapy. Isochorismatase domain-containing protein 1 (ISOC1) has putative isochorismatase act...

journal_title：Oncology letters

authors： Cheng L,Zhao Y,Tang M,Luo Z,Wang X

更新日期：2019-05-01 00:00:00

abstract：:Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...

journal_title：Oncology letters

authors： Liu J,Mi B,Wang Y,Shi C,Mi X,Lu Y,Yu P

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to determine whether manipulation of the microRNA-200 (miR-200) family could influence colon adenocarcinoma cell behavior. The miR-200 family has a significant role in tumor suppression and functions as an oncogene. In vitro studies on gain and loss of function with small interfering RNA demonstrated ...

journal_title：Oncology letters

authors： Carter JV,O'Brien SJ,Burton JF,Oxford BG,Stephen V,Hallion J,Bishop C,Galbraith NJ,Eichenberger MR,Sarojini H,Hattab E,Galandiuk S

更新日期：2019-10-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, including head and neck squamous cell carcinoma (HNSCC). Previously, TGFβ ligands were al...

journal_title：Oncology letters

authors： Bae WJ,Lee SH,Rho YS,Koo BS,Lim YC

更新日期：2016-12-01 00:00:00

abstract：:The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...

journal_title：Oncology letters

authors： Yang L,Wang XW,Zhu LP,Wang HL,Wang B,Zhao Q,Wang XY

更新日期：2018-08-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B-cell development and B-cell tumorigenesis remains poorly understood. By analy...

journal_title：Oncology letters

authors： Zhang W,He X,Hu J,Yang P,Liu C,Wang J,An R,Zhen J,Pang M,Hu K,Ke X,Zhang X,Jing H

更新日期：2019-10-01 00:00:00

abstract：:Lung cancer is one of the most lethal types of cancer, and its poor prognosis is primarily due to drug resistance and cancer recurrence. As it is associated with a low five-year survival rate, lung cancer stem cells (LCSCs) have been the subject of numerous recent studies. For these studies of LCSCs, lung cancer cell ...

journal_title：Oncology letters

authors： Wang Y,Jiang M,Du C,Yu Y,Liu Y,Li M,Luo F

更新日期：2018-05-01 00:00:00

abstract：:Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...

journal_title：Oncology letters

authors： Annovazzi L,Mellai M,Bovio E,Mazzetti S,Pollo B,Schiffer D

更新日期：2018-01-01 00:00:00

abstract：:Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...

journal_title：Oncology letters

authors： Chuthapisith S,Warnnissorn M,Amornpinyokiat N,Pradniwat K,Angsusinha T

更新日期：2013-09-01 00:00:00

abstract：:Hepatocellular carcinoma is a serious public health problem in China. The mortality rate associated with the majority of cancer types has decreased as a result of targeted therapy. However, the mortality rates associated with hepatocellular carcinoma have not improved; therefore, the identification of new molecular ta...

journal_title：Oncology letters

authors： Yuan B,Bo W,Feng X,Hu Y,Zeng J

更新日期：2020-12-01 00:00:00

abstract：:The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...

journal_title：Oncology letters

authors： Lu J,Tan H,Li B,Chen S,Xu L,Zou Y

更新日期：2020-01-01 00:00:00

abstract：:Lung cancer is the most common type of malignancy to metastasize to the brain, with the median survival time of patients being 6-11 months. In the present study, the aim was to compare the actionable gene mutation profiles of primary lung adenocarcinoma (LC) samples and LC brain metastasis (LCBM) samples through targe...

journal_title：Oncology letters

authors： Ma Y,Chen K,Yang Z,Guan M

更新日期：2018-04-01 00:00:00

abstract：:Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...

journal_title：Oncology letters

authors： Xia Y,Zhang J,Ni X

更新日期：2020-10-01 00:00:00

abstract：:The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restrictio...

journal_title：Oncology letters

authors： Ma X,Yang C,Tang R,Xu Z,Zhang Z,Wang Y,Zhang J,Yang LI

更新日期：2015-07-01 00:00:00

abstract：:Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...

journal_title：Oncology letters

authors： Jiang M,Zhuang Y,Zu WC,Jiao L,Richard SA,Zhang S

更新日期：2019-06-01 00:00:00

abstract：:Pancreatic cancer is one of the most frequently occurring malignancies worldwide and it is the fourth most common cause of cancer-associated mortality in Western countries. Thalidomide (THD) plays an important role in tumor therapy, as it is able to promote early stage apoptosis and inhibit the process of angiogenesis...

journal_title：Oncology letters

authors： Qiao Z,Yuan J,Shen J,Wang C,He Z,Hu Y,Zhang M,Xu C

更新日期：2015-05-01 00:00:00