Abstract:
:The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification with regard to clinico-pathological parameters in these types of cancer. HER2 gene amplification was evaluated by fluorescence in situ hybridization (FISH) in surgically obtained specimens from 76 cases of ESCC, 50 of GEJAC and 48 of GC, as well as 21 specimens of tumor-adjacent normal epithelium as a control group. The HER2 gene amplification rates in ESCC, GEJAC and GC were 3.9 (3/76), 24.0 (12/50) and 18.8% (9/48), respectively. The rates of HER2 gene amplification in GEJAC and GC were significantly higher compared with ESCC (χ2=11.563, P<0.001 and χ2=7.375, P<0.007, respectively). HER2 gene amplification was not detected in the normal esophageal or gastric mucosa samples. In ESCC, HER2 gene amplification was correlated with the invasion of the ESCC cells, vascular invasion and lymph node metastasis (χ2=4.789, 3.858 and 5.354, respectively; all P<0.05). However, in GEJAC and GC, no correlations were observed between HER2 amplification and the gender, age, degree of differentiation, invasion, vascular invasion and lymph node metastases of the patients (all P>0.05). The rate of HER-2 gene amplification was low in ESCC, although the amplification of HER-2 was correlated with tumor metastasis in these patients. The rates of HER-2 gene amplification in GEJAC and GC were higher compared with ESCC. Therefore, compared with ESCC, GEJAC may be more similar to GC with regard to HER-2 gene amplification features.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Huang JX,Zhao K,Lin M,Wang Q,Xiao W,Lin MS,Yu H,Chen P,Qian RYdoi
10.3892/ol.2013.1348subject
Has Abstractpub_date
2013-07-01 00:00:00pages
13-18issue
1eissn
1792-1074issn
1792-1082pii
ol-06-01-0013journal_volume
6pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::The Janus kinase (JAK)2 gene, which is located on chromosome 9p24, is involved in the signaling transduction pathways of the hematopoietic and immune system. Mutations in the JAK2 gene have served as disease markers for myeloproliferative neoplasms (MPNs). The aim of the present study was to investigate the occurrence...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2801
更新日期:2015-02-01 00:00:00
abstract::Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9195
更新日期:2018-10-01 00:00:00
abstract::High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1851
更新日期:2014-04-01 00:00:00
abstract::The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3202
更新日期:2015-07-01 00:00:00
abstract::Pulmonary benign metastasizing leiomyoma (BML) is a rare event characterized by benign soft-tissue tumors that occur when uterine leiomyomas metastasize to the lung. The present study reports the case of a 47-year-old female patient who presented with multiple bilateral pulmonary nodules on a chest X-ray during a heal...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3224
更新日期:2015-07-01 00:00:00
abstract::Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1405
更新日期:2013-08-01 00:00:00
abstract::Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6479
更新日期:2017-09-01 00:00:00
abstract::The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.342
更新日期:2011-09-01 00:00:00
abstract::The aim of the present study was to investigate the effect of HPV16E6 gene integration on the biological behavior of Eca109 and Eca9706 cells. This was evaluated through positive liposome transfection of HPV16E6 into Eca109 cells and Eca9706 cells. The transfection efficiency was evaluated by calculating the ratio of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7469
更新日期:2018-02-01 00:00:00
abstract::Dendrobium candidum Wall ex Lindl. (D. candidum) is a traditional Chinese medicine widely used in Asia. The present study has showed that D. candidum exerted an anti-metastatic effect in mice injected with 26-M3.1 colon carcinoma cells. D. candidum showed the most marked tumor inhibitory rate of 64.5% at a dose of 400...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2383
更新日期:2014-10-01 00:00:00
abstract::Breast tissue is very sensitive to ionizing radiation due to the presence of reproductive hormones, including estrogen. In the present pilot study, the efficiency of mammography X-rays to induce DNA double strand breaks (DSB) in mammary epithelial cells was investigated. For this, freshly resected healthy breast tissu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9024
更新日期:2018-09-01 00:00:00
abstract::Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5784
更新日期:2017-04-01 00:00:00
abstract::The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10293
更新日期:2019-07-01 00:00:00
abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.644
更新日期:2012-06-01 00:00:00
abstract::The flavonoid compound scutellarin (Scu) is a traditional Chinese medicine used to treat a variety of diseases; however, the use of scutellarein (Scue), the hydrolysate of Scu, and its mechanisms of action in Alzheimer's disease (AD) have not been fully elucidated. In the present study, the effects of Scue on amyloid ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10274
更新日期:2019-06-01 00:00:00
abstract::Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11008
更新日期:2019-12-01 00:00:00
abstract::The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical infl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7004
更新日期:2017-12-01 00:00:00
abstract::DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.992
更新日期:2013-01-01 00:00:00
abstract::Individuals >65 years old account for a large proportion of cancer patients, and usually have poor prognoses due to relative weaker physiological function and lower drug tolerance. To characterize the efficacy and safety of dendritic cell (DC)-activated cytokine-induced killer cell (CIK)-mediated treatment, and develo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5337
更新日期:2016-12-01 00:00:00
abstract::Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4264
更新日期:2016-04-01 00:00:00
abstract::Chemotherapy has been widely used in breast cancer therapy, but the efficacy of chemotherapy is intimately associated with the sensitivity of therapeutic drugs to breast cancer. Docetaxel is a first-line chemotherapeutic drug in breast cancer treatment, but further improvement to its efficacy has thus far proved diffi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4030
更新日期:2016-02-01 00:00:00
abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7116
更新日期:2017-12-01 00:00:00
abstract::Sclerosing stromal tumor (SST) of the ovary, which was first described by Chalvardjian and Scully in 1973, is a rare ovarian neoplasm, occurring predominantly in young women. The most common clinical symptom in patients with SST is menstrual irregularities. Microscopically, the tumor is characterized by the presence o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4441
更新日期:2016-06-01 00:00:00
abstract::The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7053
更新日期:2017-12-01 00:00:00
abstract::Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10347
更新日期:2019-07-01 00:00:00
abstract::The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4064
更新日期:2016-02-01 00:00:00
abstract::It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6917
更新日期:2017-11-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) show great promise as novel cancer biomarkers. Several studies have revealed an association between abnormal miRNA expression and the risk of various cancer types. However, the diagnostic accuracy and reliability of miRNAs remains unclear. The present meta-analysis was performed to summarize th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9489
更新日期:2018-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in the insulin-like growth factor-1 (IGF-1) receptor signalling pathway during experimental hepatocarcinogenesis. The aim of this study was ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.546
更新日期:2012-03-01 00:00:00