Abstract:
:The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB. The treatment effect was evaluated by spiral CT scanning prior to, during and following treatment (at 0 weeks and the end of 1 and 2 weeks). The tumor growth rate was recorded. The specimens of VX2 tumors were collected for histological examination and transmission electron microscopy (TEM). No significant differences were observed between tumor areas measured by CT and pathology after 2-week treatment (P>0.05). The mean tumor growth rates in the control, MB, US and US + MB groups after 2 weeks of treatment were 385±21, 353±12, 302±14 and 154±9%, respectively (P<0.05, US + MB vs. the other three groups). Hematoxylin and eosin staining in the US + MB group revealed coagulation necrosis, interstitial hemorrhage and intravascular thrombosis. In the control, MB and US groups, tumor cells exhibited clear nuclear hyperchromatism. TEM of US + MB revealed vascular endothelial cell wall rupture, widened endothelial cell gaps, interstitial erythrocyte leakage and microvascular thrombosis, while intact vascular endothelial cells and normal erythrocytes in the tumor vessels were observed in the control, MB and US groups. A combination of 20 kHz US and MBs may effectively inhibit rabbit VX2 tumors. Spiral CT scanning is an ideal method to evaluate the US treatment on rabbit tumors.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Shen ZY,Liu C,Wu MF,Shi HF,Zhou YF,Zhuang W,Xia GLdoi
10.3892/ol.2017.6557subject
Has Abstractpub_date
2017-09-01 00:00:00pages
3124-3130issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-6557journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study aimed to ascertain whether suppression of midkine (MK) expression in pancreatic cancer cells inhibits metastasis to the liver. Human pancreatic cancer AsPC-1 cells were transfected with small interfering RNA (siRNA) targeting MK. siRNA against MK was observed to reduce the expression of MK mRNA and p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1572
更新日期:2013-11-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. Currently, 5-fluorouracil (5-FU) remains a widely used chemotherapeutic drug in the treatment of CRC; however, 5-FU resistance during treatment has become a common problem. Livin, a member of the inhibitor of apoptosis pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8282
更新日期:2018-05-01 00:00:00
abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11897
更新日期:2020-10-01 00:00:00
abstract::To define the correlation between BCR promoter DNA methylation and response to imatinib in chronic myeloid leukemia (CML), we investigated BCR promoter DNA methylation in three groups of subjects. The first group included chronic phase patients enrolled in an imatinib dose escalation trial. In the trial, patients who ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.208
更新日期:2011-01-01 00:00:00
abstract::Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6049
更新日期:2017-06-01 00:00:00
abstract::Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3488
更新日期:2015-09-01 00:00:00
abstract::As a rare hypopharyngeal diverticulum, Killian-Jamieson diverticulum (KJD) is usually incidentally detected, small, asymptomatic and likely to be misdiagnosed as a thyroid nodule. In order to avoid unnecessary treatments resulting from misdiagnosis, principles to distinguish between esophageal diverticula and thyroid ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4984
更新日期:2016-10-01 00:00:00
abstract::In the present study, the expression level of microRNA-146a-5p (miR-146a-5p) in breast cancer tissue and cell lines was investigated and its effects on proliferation of breast cancer cells. miR-146a-5p expression was detected by reverse transcription-quantitative polymerase chain reaction in breast cancer tissues, par...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8589
更新日期:2018-06-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1405
更新日期:2013-08-01 00:00:00
abstract::The putative oncogenic role of ATP/GTP binding protein like 2 (AGBL2) in catalyzing α-tubulin detyrosination has recently been characterized in cancer. However, the status of AGBL2 expression in ovarian cancer and its potential clinical and prognostic significance remain unclear. In the present study, immunohistochemi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10829
更新日期:2019-11-01 00:00:00
abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.603
更新日期:2012-05-01 00:00:00
abstract::Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10347
更新日期:2019-07-01 00:00:00
abstract::The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2521
更新日期:2014-11-01 00:00:00
abstract::The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6159
更新日期:2017-07-01 00:00:00
abstract::Increasing evidence has confirmed that long non-coding RNAs (lncRNAs) serve critical roles in the development of a large number of human malignancies, including glioma. Several previously published studies have reported that the lncRNA retinal non-coding RNA3 (RNCR3; also termed LINC00599) exerts important roles in ce...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11002
更新日期:2019-12-01 00:00:00
abstract::The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10505
更新日期:2019-08-01 00:00:00
abstract::The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10517
更新日期:2019-08-01 00:00:00
abstract::The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1844
更新日期:2014-04-01 00:00:00
abstract::Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5125
更新日期:2016-11-01 00:00:00
abstract::Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9467
更新日期:2018-11-01 00:00:00
abstract::Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1853
更新日期:2014-04-01 00:00:00
abstract::Exosomes derived from tumor cells are essential for processes involved in tumor progression, including angiogenesis, tumor cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis and metastasis of tumors. In the present study, as it is on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3841
更新日期:2016-01-01 00:00:00
abstract::Colon cancer is the second most common type of cancer in females and the third in males, worldwide. The most common sites of colon cancer metastasis are the regional lymph nodes, liver, lung, bone and brain. In this study, an extremely rare case of colon adenocarcinoma with extensive metastasis to the mediastinal lymp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2426
更新日期:2014-11-01 00:00:00
abstract::Giant osteomas of the ethmoid and frontal sinuses ary very rare, with only a few dozen cases reported in the literature. Given their rarity, the clinical characteristics and treatment of this disease remain controversial. In this study, the clinical presentation and surgical methods used to treat three patients with g...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1239
更新日期:2013-05-01 00:00:00
abstract::We previously reported that the dissected pancreatic tissue margin (DPM) and the preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in pancreatic ductal adenocarcinoma (PDAC). In the current study, the prognostic relevance of these factors, including their molecular a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9839
更新日期:2019-02-01 00:00:00
abstract::Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and ass...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7228
更新日期:2017-12-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11534
更新日期:2020-07-01 00:00:00
abstract::Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's Hospital. The clinicopa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1872
更新日期:2014-04-01 00:00:00