Leiomyosarcoma of the thyroid gland: A case report and literature review.

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:Point mutation of the BRAF gene is a genetic event that occurs in a subset of lung adenocarcinoma cases. For example, BRAF V600E is a driver mutation that can be effectively targeted using selective BRAF and/or MEK inhibitors. The present study hypothesized that an increase in BRAF copy number may be correlated with c...

journal_title：Oncology letters

authors： Sasaki H,Maekawa M,Tatematsu T,Okuda K,Moriyama S,Yano M,Fujii Y

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...

journal_title：Oncology letters

authors： Liang T,Hu B,Du H,Zhang Y

更新日期：2020-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...

journal_title：Oncology letters

authors： Huang Z,Zhang N,Li W,Cao J,Zhang L,Chen Y

更新日期：2017-02-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...

journal_title：Oncology letters

authors： Tang H,Xu L,Liang X,Gao G

更新日期：2018-11-01 00:00:00

abstract：:Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwen...

journal_title：Oncology letters

authors： Lou X,Hou Y,Cao H,Zhao J,Zhu F

更新日期：2018-07-01 00:00:00

abstract：:Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Wang P,Zhao JG,Wang ZF,Chen LI

更新日期：2016-05-01 00:00:00

abstract：:Pristimerin is an active compound isolated from the traditional Chinese herbs Celastraceae and Hippocrateaceae. It has been reported to exert antitumor effects under experimental and clinical conditions; however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been iden...

journal_title：Oncology letters

authors： Wu H,Li L,Ai Z,Yin J,Chen L

更新日期：2019-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age...

journal_title：Oncology letters

authors： Huo X,Yuan K,Shen Y,Li M,Wang Q,Xing L,Shi G

更新日期：2014-07-01 00:00:00

abstract：:Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...

journal_title：Oncology letters

authors： Zhang X,Fu Z,Gong G,Wei H,Duan J,Chen Z,Chen X,Wang R,Yin Y

更新日期：2017-09-01 00:00:00

abstract：:Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...

journal_title：Oncology letters

authors： Guo Q,He Y,Sun L,Kong C,Cheng Y,Zhang G

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two human colon carcinoma cell lines, DLD-1 and WiDr. Colon carcinoma cells were treated with various concentrations of aloe-emodin for different durations. Cell viability was m...

journal_title：Oncology letters

authors： Lin KY,Uen YH

更新日期：2010-05-01 00:00:00

abstract：:Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...

journal_title：Oncology letters

authors： Chen X,Zhang Y,Wang F,Wang M,Teng W,Lin Y,Han X,Jin F,Xu Y,Cao P,Fang J,Zhu P,Tong C,Liu H

更新日期：2017-11-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...

journal_title：Oncology letters

authors： Ishida M,Okabe H

更新日期：2012-09-01 00:00:00

abstract：:Osteosarcoma is known as a malignant tumour with a high mortality rate in orthopaedic settings; however, the factors associated with its degree of malignancy and the biological response remains to be elucidated. Although the essential role of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been recen...

journal_title：Oncology letters

authors： Shi Y,Lv C,Shi L,Tu G

更新日期：2018-02-01 00:00:00

abstract：:Recently, a number of microRNAs (miRNAs) have been reported to play different roles in human cancers, including colorectal cancer (CRC). However, the specific role of miR-758 has not been clarified in CRC. Therefore, the aim of the present study was to explore the role of miR-758 in CRC. RT-qPCR and western blot analy...

journal_title：Oncology letters

authors： Zhang X,Xu J,Zhang H,Sun J,Li N,Huang X

更新日期：2020-06-01 00:00:00

abstract：:Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the si...

journal_title：Oncology letters

authors： Gamoh S,Akiyama H,Tominaga K,Nakajima M,Kakudo K,Tanaka A,Shimizutani K

更新日期：2015-08-01 00:00:00

abstract：:Ascorbic acid (A) has been demonstrated to exhibit anti-cancer activity in association with chemotherapeutic agents. Potassium (K) is a regulator of cellular proliferation. In the present study, the biological effects of A and K bicarbonate, alone or in combination (A+K), on breast cancer cell lines were evaluated. Th...

journal_title：Oncology letters

authors： Frajese GV,Benvenuto M,Fantini M,Ambrosin E,Sacchetti P,Masuelli L,Giganti MG,Modesti A,Bei R

更新日期：2016-06-01 00:00:00

abstract：:Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imagi...

journal_title：Oncology letters

authors： Benej R,Mečiarová I,Pohlodek K

更新日期：2017-08-01 00:00:00

abstract：:The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

journal_title：Oncology letters

authors： Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

更新日期：2018-04-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation and has been associated with numerous high-risk cancers. Previously, our group and others identified LSD1 as an upregulated gene in ovarian cancer, and reported that the upregulation of LSD1 was associated...

journal_title：Oncology letters

authors： Shao G,Wan X,Lai W,Wu C,Jin J,Liu X,Wei Y,Lin Q,Zhang L,Shao Q

更新日期：2018-06-01 00:00:00

abstract：:Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression ...

journal_title：Oncology letters

authors： Zhang EL,Gu J,Zhang ZY,Dong KS,Liang BY,Huang ZY

更新日期：2017-07-01 00:00:00

abstract：:The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...

journal_title：Oncology letters

authors： Liu P,Yao Q,Li NA,Liu Y,Wang Y,Li M,Li Z,Li J,Li G

更新日期：2016-05-01 00:00:00

abstract：:Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type ...

journal_title：Oncology letters

authors： He H,Li J,Xu M,Kan Z,Gao Y,Yuan C

更新日期：2019-09-01 00:00:00

abstract：:The present study aims to investigate the radiosensitization effect of the migration and invasion inhibitory protein (MIIP) gene on nasopharyngeal carcinoma (NPC) cells. The MIIP gene was transfected into NPC 5-8F and CNE2 cells. The level of MIIP was analyzed by quantitative reverse transcription-polymerase chain rea...

journal_title：Oncology letters

authors： Zhou HP,Qian LX,Zhang N,Gu JJ,Ding K,Wu J,Lu ZW,Du MY,Zhu HM,Wu JZ,He X,Yin L

更新日期：2018-06-01 00:00:00

abstract：:The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...

journal_title：Oncology letters

authors： Li J,Xie Y,Wang X,Jiang C,Yuan X,Zhang A,Yang L,Liu C,Zou H,Li F,Hu J

更新日期：2020-11-01 00:00:00

abstract：:Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Fu...

journal_title：Oncology letters

authors： Zhu J,Lian L,Qin H,Wang WJ,Ren R,Xu MD,Chen K,Duan W,Gong FR,Tao M,Zhi Q,Wu MY,Li W

更新日期：2019-02-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...

journal_title：Oncology letters

authors： Cai LL,Wang J

更新日期：2019-06-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00