Abstract:
:Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention in the medical field. However, it also causes a series of adverse reactions and increases the risk of recurrence. The present review examines the results of CD19 CAR T-cell therapy and lists its adverse effects. In addition, some of the mechanisms of recurrence are characterized and applicable strategies to address this challenging problem are proposed.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Fu Z,Zhou J,Chen R,Jin Y,Ni T,Qian L,Xiao Cdoi
10.3892/ol.2020.11897subject
Has Abstractpub_date
2020-10-01 00:00:00pages
36issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-11897journal_volume
20pub_type
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