The clinical analysis of small supernumerary marker chromosomes in 17 children with mos 45,X/46,X,+mar karyotype.

abstract：:The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...

journal_title：Oncology letters

authors： Wu J,Niu Q,Yuan J,Xu X,Cao L

更新日期：2020-07-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated ...

journal_title：Oncology letters

authors： Zhou N,Lu F,Liu C,Xu K,Huang J,Yu D,Bi L

更新日期：2016-09-01 00:00:00

abstract：:Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...

journal_title：Oncology letters

authors： Xiao M,Yang Z,Tang X,Mu L,Cao X,Wang X

更新日期：2017-08-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...

journal_title：Oncology letters

authors： Ishida M,Okabe H

更新日期：2012-09-01 00:00:00

abstract：:Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. In the present study, TFC was found to potent...

journal_title：Oncology letters

authors： Sheng Y,Zou M,Wang Y,Li Q

更新日期：2015-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...

journal_title：Oncology letters

authors： Hu Z,Xie F,Hu A,Xu M,Liu Y,Zhang J,Xiao J,Song Y,Zhong J,Chen B

更新日期：2020-11-01 00:00:00

abstract：:In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and...

journal_title：Oncology letters

authors： Xu XM,Zhang ML,Zhang Y,Zhao L

更新日期：2016-11-01 00:00:00

abstract：:MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...

journal_title：Oncology letters

authors： Lin MH,Chen YZ,Lee MY,Weng KP,Chang HT,Yu SY,Dong BJ,Kuo FR,Hung LT,Liu LF,Chen WS,Tsai KW

更新日期：2018-06-01 00:00:00

abstract：:Andrographolide (Andro), a natural compound isolated from Andrographis paniculata, has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using...

journal_title：Oncology letters

authors： Liu G,Chu H

更新日期：2018-04-01 00:00:00

abstract：:Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation ente...

journal_title：Oncology letters

authors： Sugita S,Inomata M,Kono Y,Shiroshita H,Etoh T,Shiraishi N,Kitano S

更新日期：2013-11-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:Distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is upregulated in various solid tumors and serves a critical role in the tumorigenesis of cancer. However, to the best of our knowledge, the expression of circulating DLX6-AS1 and its role in the diagnosis of non-small cell lung cancer (NSCLC) have not been previously ...

journal_title：Oncology letters

authors： Zhang X,Guo H,Bao Y,Yu H,Xie D,Wang X

更新日期：2019-11-01 00:00:00

abstract：:Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...

journal_title：Oncology letters

authors： Liang L,Zeng M,Pan H,Liu H,He Y

更新日期：2018-04-01 00:00:00

abstract：:Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

journal_title：Oncology letters

authors： Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

更新日期：2017-07-01 00:00:00

abstract：:Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...

journal_title：Oncology letters

authors： Xie H,Lu Q,Wang H,Zhu X,Guan Z

更新日期：2019-01-01 00:00:00

abstract：:It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the hu...

journal_title：Oncology letters

authors： Cheng L,Kong B,Zhao Y,Jiang J

更新日期：2018-03-01 00:00:00

abstract：:Lung cancer is one of the most common malignant cancers in the Czech Republic in men, with the highest mortality rate of all the malignant diseases. The development of biological treatment enables study into novel personalized treatment options. This type of treatment is usually of high quality, and is often demanding...

journal_title：Oncology letters

authors： Stanek L,Springer D,Konopasek B,Vocka M,Tesarova P,Syrucek M,Petruzelka L,Vicha A,Musil Z

更新日期：2017-12-01 00:00:00

abstract：:The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...

journal_title：Oncology letters

authors： Ren HP,Yin XY,Yu HY,Xiao HF

更新日期：2017-04-01 00:00:00

abstract：:Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...

journal_title：Oncology letters

authors： Tan KT,Chen PW,Li S,Ke TM,Lin SH,Yang CC

更新日期：2019-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common tumor in south China. Kinesin family member 2A (KIF2A) belongs to the kinesin-13 family and is associated with the growth and invasion of a number of different types of human cancer, including ovarian, breast and prostate cancer. The aim of the present study was to evaluate t...

journal_title：Oncology letters

authors： Zhang Q,Lu D,Liu W,Ye S,Guo H,Liao T,Chen C

更新日期：2019-09-01 00:00:00

abstract：:Emerging evidence has revealed that mitochondrial DNA (mtDNA) is encapsulated in plasma extracellular vesicles (EVs). However, the characteristics of mtDNA in EVs from patients with cancer remain largely unexplored, which greatly limits its clinical application. Whole genome and capture-based sequencing found that EV ...

journal_title：Oncology letters

authors： Li Y,Guo X,Guo S,Wang Y,Chen L,Liu Y,Jia M,An J,Tao K,Xing J

更新日期：2020-09-01 00:00:00

abstract：:Maternal embryonic leucine zipper kinase (MELK) is an important regulator in tumorigenesis of human breast cancer, and if silenced leads to programmed cell death in specific breast cancer cell lines, including MDA-MB-231 cells. In the present study, RNA interference, proliferation assay and semi-quantification of cell...

journal_title：Oncology letters

authors： Li G,Yang M,Zuo L,Wang MX

更新日期：2018-06-01 00:00:00

abstract：:Approximately 34-86% of neoplasms of the salivary glands are located in the parotid gland and parotidectomy is the first-line treatment for parotid gland tumors. Frey syndrome and cosmetic deformity are common complications experienced by patients following parotidectomy and the sternocleidomastoid muscle flap (SCMF) ...

journal_title：Oncology letters

authors： Liu DY,Tian XJ,Li C,Sun SS,Xiong YH,Zeng XT

更新日期：2013-04-01 00:00:00

abstract：:Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...

journal_title：Oncology letters

authors： Yang H,Wang R,Zeng F,Zhao J,Peng S,Ma Y,Chen S,Ding S,Zhong L,Guo W,Wang W

更新日期：2020-10-01 00:00:00

abstract：:Increasing evidence has confirmed that long non-coding RNAs (lncRNAs) serve critical roles in the development of a large number of human malignancies, including glioma. Several previously published studies have reported that the lncRNA retinal non-coding RNA3 (RNCR3; also termed LINC00599) exerts important roles in ce...

journal_title：Oncology letters

authors： Zhu B,Zhang S,Meng N,Zhang H,Yuan S,Zhang J

更新日期：2019-12-01 00:00:00

abstract：:The Janus kinase (JAK)2 gene, which is located on chromosome 9p24, is involved in the signaling transduction pathways of the hematopoietic and immune system. Mutations in the JAK2 gene have served as disease markers for myeloproliferative neoplasms (MPNs). The aim of the present study was to investigate the occurrence...

journal_title：Oncology letters

authors： Zhang SP,Li H,Lai RS

更新日期：2015-02-01 00:00:00

abstract：:Clinical application value was investigated of transvaginal color Doppler ultrasound (TV-CDS) combined with serum tumor markers carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF) and osteopontin (OPN) in the diagnosis of ovarian cancer (OC). One hundred and six patients with OC [malignant tumo...

journal_title：Oncology letters

authors： Yu C,Dou T,Liu Y,Liu R

更新日期：2020-08-01 00:00:00

abstract：:The present study analyzed polymorphisms of the 5' flanking region (from nt -840 to +151) of the haptoglobin gene in 120 patients with advanced non-small cell lung cancer (NSCLC) receiving personalized peptide vaccinations. In the region, six single nucleotide polymorphisms (SNPs) were confirmed, of which two, rs5472 ...

journal_title：Oncology letters

authors： Waki K,Yamada T,Yoshiyama K,Terazaki Y,Sakamoto S,Sugawara S,Takamori S,Itoh K,Yamada A

更新日期：2017-02-01 00:00:00

abstract：:Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the pr...

journal_title：Oncology letters

authors： Yang T,Mao P,Chen X,Niu X,Xu G,Bai X,Xie W

更新日期：2019-02-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

journal_title：Oncology letters

authors： Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

更新日期：2016-12-01 00:00:00