Abstract:
:The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated with the metastasis of RCC; however, the underlying molecular mechanism has not been determined yet. The present study revealed that interleukin (IL)-8 was highly expressed in metastatic RCC. IL-8 could induce the EMT of an RCC cell line by enhancing N-cadherin expression and decreasing E-cadherin expression. Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8. Therefore, these results suggest that IL-8 is able to promote the EMT of RCC through the activation of the AKT signal transduction pathway, and this may provide a possible molecular mechanism for RCC metastasis.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhou N,Lu F,Liu C,Xu K,Huang J,Yu D,Bi Ldoi
10.3892/ol.2016.4900subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1915-1920issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-4900journal_volume
12pub_type
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