Abstract:
:Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study aimed to investigate the antitumor effects and molecular mechanisms of pterostilbene in the human lung squamous cell carcinoma (SqCC) cell line, H520. The results of the present study indicate that pterostilbene significantly reduced cell viability and induced S phase arrest, and that treatment with pterostilbene was associated with the downregulation of cyclin A and cyclin E, as with the upregulation of p21 and p27 expression in H520 cells. In the apoptosis analysis, pterostilbene induced S phase accumulation and the activation of caspase-3, -8 and -9 in H520 cells, potentially through the activation of extrinsic and intrinsic apoptotic pathways. Additionally, the in vivo study demonstrated that pterostilbene effectively inhibited lung SqCC growth in a H520 ×enograft model. Given the in vitro and in vivo antitumor effects of pterostilbene demonstrated in the present study, pterostilbene may serve a novel and effective therapeutic agent to for patients with SqCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Tan KT,Chen PW,Li S,Ke TM,Lin SH,Yang CCdoi
10.3892/ol.2019.10499subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1631-1640issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-10499journal_volume
18pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Activating transcription factor 2 (ATF2) is a member of the cAMP response element binding protein family that heterodimerizes and activates other transcription factors involved in stress and DNA damage responses, growth, differentiation and apoptosis. ATF2 has been investigated as a potential carcinogenic biomarker in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3922
更新日期:2016-01-01 00:00:00
abstract::TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1344
更新日期:2013-07-01 00:00:00
abstract::The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6529
更新日期:2017-09-01 00:00:00
abstract::In recent decades, thyroid cancer (TC) has become one of the most common endocrine malignancies. Next-generation sequencing of paired TC and adjacent healthy thyroid tissues demonstrated that polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) may serve as a tumour suppressor gene in thyroid cancer. However, the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10632
更新日期:2019-09-01 00:00:00
abstract::Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5186
更新日期:2016-11-01 00:00:00
abstract::Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10956
更新日期:2019-12-01 00:00:00
abstract::Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7885
更新日期:2018-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a serious threat to human health. Chemotherapy drugs such as cisplatin are widely used in cancer treatment, but can cause severe side effects. Hydroxyl safflower yellow A (HSYA) is a water-soluble chalcone glycoside substance extracted from safflowers (Carthamus tinctorius L.) that ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9946
更新日期:2019-03-01 00:00:00
abstract::Previous studies have revealed the aberrant expression of a number of microRNAs (miRNA/miRs) in the blood circulation of patients with breast cancer (BC). The aim of the present study was to assess the effect of neoadjuvant chemotherapy on the levels of a panel of BC-associated miRNAs, which are at relatively low (let...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2188
更新日期:2014-08-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::There are multiple bioinformatics tools available for the detection of coding driver mutations in cancers. However, the prioritization of pathogenic non-coding variants remains a challenging and demanding task. The present study was performed to discriminate non-coding disease-causing mutations and prioritize potentia...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5135
更新日期:2016-11-01 00:00:00
abstract::Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000147
更新日期:2010-09-01 00:00:00
abstract::To assess the influence of microRNA-183 (miR-183) on the migration and invasion of A375 human melanoma cells, an A375 cell line with stable miR-183 overexpression or knockdown was constructed using lentiviral transfection. The change of miR-183 expression in these cells and in non-transfected controls was verified usi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9603
更新日期:2019-01-01 00:00:00
abstract::ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10454
更新日期:2019-08-01 00:00:00
abstract::Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2010
更新日期:2014-06-01 00:00:00
abstract::Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9448
更新日期:2018-11-01 00:00:00
abstract::Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6718
更新日期:2017-10-01 00:00:00
abstract::The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9394
更新日期:2018-11-01 00:00:00
abstract::Cervical carcinoma expressed PCNA regulatory long non-coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12006
更新日期:2020-11-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, and has high incidence and mortality rates, worldwide. Myelodysplastic syndrome (MDS), a disorder of hematopoietic stem or progenitor cells, results in marrow failure, which increases the risk of acute myeloid leukemia (AML). Few stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12129
更新日期:2020-11-01 00:00:00
abstract::Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9467
更新日期:2018-11-01 00:00:00
abstract::The present study evaluated the association between programmed cell death ligand-1 (PD-L1) expression and long-term oncologic outcomes in colorectal cancer (CRC). PD-L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9264
更新日期:2018-10-01 00:00:00
abstract::Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4606
更新日期:2016-07-01 00:00:00
abstract::A 56-year-old male patient with locally advanced mucinous rectal cancer underwent neoadjuvant chemoradiotherapy. Follow-up imaging with positron emission tomography-computed tomography (PET-CT) revealed a local response to chemoradiotherapy, whereas diffusion-weighted magnetic resonance imaging (DW-MRI) showed newly p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.663
更新日期:2012-06-01 00:00:00
abstract::Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10681
更新日期:2019-10-01 00:00:00
abstract::Death associated protein kinase 1 (DAPK1) is a notable serine/threonine kinase involved in the regulation of multiple cellular pathways, including apoptosis and autophagy. Although DAPK1 is usually considered to be a tumor suppressor, it was previously reported to promote the viability of p53 mutant cancer cell lines ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8439
更新日期:2018-06-01 00:00:00
abstract::The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2826
更新日期:2015-03-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11170
更新日期:2020-01-01 00:00:00
abstract::A previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10711
更新日期:2019-10-01 00:00:00
abstract::Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to augmentation of AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7556
更新日期:2018-02-01 00:00:00