Hydroxyl safflower yellow A regulates the tumor immune microenvironment to produce an anticancer effect in a mouse model of hepatocellular carcinoma.

abstract：:Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...

journal_title：Oncology letters

authors： Zhang ZH,Luan ZY,Han F,Chen HQ,Liu WB,Liu JY,Cao J

更新日期：2019-11-01 00:00:00

abstract：:Studies investigating the effects of microRNA (miR)-155 on the behavior of tumor cells have concentrated primarily on proliferation and apoptosis. The aim of the present study was to investigate the effect of miR-155 inhibitor on the metastatic and invasive ability of gastric carcinoma cells and whether this effect is...

journal_title：Oncology letters

authors： Wei H,Li Y,Ning Q,Suo ZM

更新日期：2018-10-01 00:00:00

abstract：:The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...

journal_title：Oncology letters

authors： Hufnagl C,Leisch M,Weiss L,Melchardt T,Moik M,Asslaber D,Roland G,Steininger P,Meissnitzer T,Neureiter D,Greil R,Egle A

更新日期：2020-02-01 00:00:00

abstract：:Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...

journal_title：Oncology letters

authors： Tajima T,Miyazawa M,Hayashi M,Asai S,Ikeda M,Shida M,Hirasawa T,Iwamori M,Mikami M

更新日期：2017-01-01 00:00:00

abstract：:The present study aimed to reveal the key long non-coding RNAs (lncRNAs) and the potential molecular mechanisms of XAV939 treatment in non-small cell lung cancer (NSCLC). The NSCLC cell line, NCI-H1299, was cultured with 10 µM XAV939 for 12 h, and NCI-H1299 cells without XAV939 treatment were used as controls. Followi...

journal_title：Oncology letters

authors： Yu H,Han Z,Xu Z,An C,Xu L,Xin H

更新日期：2019-06-01 00:00:00

abstract：:A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, part...

journal_title：Oncology letters

authors： Yang M,Xu J,Wang Q,Zhang AQ,Wang K

更新日期：2018-03-01 00:00:00

abstract：:Propofol is an intravenous anesthetic, which is widely used in clinical anesthesia induction and maintenance and is critical in the sedation of patients. However, the functions and mechanisms of propofol on apoptosis of melanoma cells remain unclear. The present study investigated whether propofol promotes cell apopto...

journal_title：Oncology letters

authors： Shang Z,Feng H,Cui L,Wang W,Fu H

更新日期：2018-01-01 00:00:00

abstract：:Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...

journal_title：Oncology letters

authors： Colombo J,Maciel JM,Ferreira LC,DA Silva RF,Zuccari DA

更新日期：2016-07-01 00:00:00

abstract：:FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...

journal_title：Oncology letters

authors： Jin K,Lan H,Cao F,Xu Z,Han N,Li G,He K,Teng L

更新日期：2012-05-01 00:00:00

abstract：:In colorectal cancer (CRC), KRAS and BRAF mutations in primary tumors are associated with resistance to anti-epidermal growth factor receptor (anti-EGFR)-based therapies. However, the correlation between KRAS/BRAF mutation in primary tumors and serum has not been well studied. To evaluate the degree of concordance of ...

journal_title：Oncology letters

authors： Pu X,Pan Z,Huang Y,Tian Y,Guo H,Wu L,He X,Chen X,Zhang S,Lin T

更新日期：2013-01-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00

abstract：:The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...

journal_title：Oncology letters

authors： Alam B,Majumder R,Akter S,Lee SH

更新日期：2015-02-01 00:00:00

abstract：:The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...

journal_title：Oncology letters

authors： Wu Y,Sun W,Kong Y,Liu B,Zeng M,Wang W

更新日期：2018-07-01 00:00:00

abstract：:Cerebroma, a nervous system tumor located in the cranial cavity, seriously affects health and may even become life-threatening. The aim of the study was to investigate and discuss the expression levels of cluster of differentiation 44 (CD44) and Golgi protein 73 (GP73) in different types of cerebroma tissues and to st...

journal_title：Oncology letters

authors： Yuan Y,Shi L,Wang S

更新日期：2018-04-01 00:00:00

abstract：:Poor nutritional status is common in ovarian cancer. It is well known that the nutritional status of a patient with malignant disease is associated with survival, and that it can be assessed by serum levels of rapid turnover proteins (RTPs), such as retinol binding protein, prealbumin and transferrin. Systemic inflamm...

journal_title：Oncology letters

authors： Watanabe T,Shibata M,Nishiyama H,Soeda S,Furukawa S,Gonda K,Takenoshita S,Fujimori K

更新日期：2014-02-01 00:00:00

abstract：:Bone metastasis is an uncommon event in advanced gastric cancer patients and bone metastases are rarely detected as isolated lesions. However, eleven years after treatment for locally advanced gastric cancer, including total gastrectomy followed by adjuvant chemotherapy, a 49-year-old female was admitted to the IX Div...

journal_title：Oncology letters

authors： Iovino F,Orditura M,Auriemma PP,Ciorra FR,Giordano G,Orabona C,Bara F,Sergio R,Savastano B,Fabozzi A,Laterza MM,Ventriglia J,Petrillo A,Della Corte CM,DE Vita F

更新日期：2015-03-01 00:00:00

abstract：:Epithelial ovarian cancer has the highest mortality of all gynecological cancers, and its progression is often without symptoms. Clinical outcome and survival may be improved if the disease is identified in the early stages. The objective of the study was to evaluate the utility of the serum biomarkers human epididymi...

journal_title：Oncology letters

authors： Fritz-Rdzanek A,Grzybowski W,Beta J,Durczyński A,Jakimiuk A

更新日期：2012-09-01 00:00:00

abstract：:Andrographolide (Andro), a natural compound isolated from Andrographis paniculata, has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using...

journal_title：Oncology letters

authors： Liu G,Chu H

更新日期：2018-04-01 00:00:00

abstract：:In the present study, we analyzed the supra-additive effect of oxaliplatin in combination with gemcitabine on terminal colorectal cancer and its influence on high-mobility group box 1 (HMGB1) expression. A total of 86 patients with terminal colorectal cancer were enrolled in this study. Patients received oxaliplatin i...

journal_title：Oncology letters

authors： Wen S,Du X,Gou Y,Jiang L

更新日期：2016-11-01 00:00:00

abstract：:A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...

journal_title：Oncology letters

authors： Kim DD,Yang CS,Chae HD,Kwak SG,Jeon CH

更新日期：2017-07-01 00:00:00

abstract：:Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study exami...

journal_title：Oncology letters

authors： Yanai Y,Hayashi T,Akazawa Y,Yatagai N,Tsuyama S,Yao T,Saito T

更新日期：2020-07-01 00:00:00

abstract：:Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second ...

journal_title：Oncology letters

authors： Liu Z,Li Y,Luo Q

更新日期：2018-11-01 00:00:00

abstract：:A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...

journal_title：Oncology letters

authors： Mantas D,Kostakis ID,Machairas N,Markopoulos C

更新日期：2016-08-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...

journal_title：Oncology letters

authors： Yang L,Wang Y,Wang H

更新日期：2019-12-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

journal_title：Oncology letters

authors： Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

更新日期：2016-12-01 00:00:00

abstract：:Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in orde...

journal_title：Oncology letters

authors： Li D,Wei X,Ma M,Jia H,Zhang Y,Kang W,Wang T,Shi X

更新日期：2017-04-01 00:00:00

abstract：:Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

journal_title：Oncology letters

authors： Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

更新日期：2014-03-01 00:00:00

abstract：:The present study aimed to investigate the clinical characteristics, diagnosis and treatment of accessory breast cancer, and contribute valuable information regarding this rare tumour to the current literature, ultimately facilitating the development of improved treatment strategies. The present study reported the cas...

journal_title：Oncology letters

authors： Zhang S,Yu YH,Qu W,Zhang Y,Li J

更新日期：2015-09-01 00:00:00

abstract：:The seven-amino acid truncated (7ND) protein is an N-terminal deletion mutant of monocyte chemoattractant protein-1 (MCP-1) and it functions as a dominant-negative inhibitor. 7ND and wild-type MCP-1 form a heterodimer, which binds to MCP-1 receptors and inhibits monocyte chemotaxis. In the present study, the 7ND prote...

journal_title：Oncology letters

authors： Luo S,Zhou C,Zhang J,Chen M,Li H,Zheng S,Quan J

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to construct the eukaryotic expression vector pEGFP-N1-hPer2 and assess its expression in the human osteosarcoma cell line MG63. Total mRNA was extracted from human osteosarcoma MG63 cells, the human period 2 (hPer2) gene was obtained by reverse transcription-polymerase chain reaction (RT-PCR...

journal_title：Oncology letters

authors： Cheng A,Zhang Y,Mei H,Fang S,Ji P,Yang J,Yu L,Guo W

更新日期：2016-04-01 00:00:00