Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways.

abstract：:Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...

journal_title：Oncology letters

authors： Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

更新日期：2014-02-01 00:00:00

abstract：:Cytokine therapy is commonly used for tumor immunotherapy. Although early studies focused directly on the tumor, current investigations are more attentive of the tumor microenvironment. Various immune cells and related cytokines in the tumor microenvironment play an important role in the occurrence and development of ...

journal_title：Oncology letters

authors： Yang L,Liu H,Zhang L,Hu J,Chen H,Wang L,Yin X,Li Q,Qi Y

更新日期：2016-12-01 00:00:00

abstract：:Certain internal malignancies, including colon cancer, can develop endobronchial metastasis. The present study reports a case of colon cancer with superficial-type endobronchial metastases in a 76-year-old male. Chest computed tomography revealed small masses and infiltrates in each lung, with bilateral hilar lymph no...

journal_title：Oncology letters

authors： Kurishima K,Satoh H,Kagohashi K,Miyazaki K,Tamura T,Shiozawa T,Ohara G,Kawaguchi M,Takayashiki N,Hizawa N

更新日期：2014-11-01 00:00:00

abstract：:Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylase...

journal_title：Oncology letters

authors： Shi Y,He R,Yang Y,He Y,Zhan L,Wei B

更新日期：2020-11-01 00:00:00

abstract：:Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...

journal_title：Oncology letters

authors： Wang ZP,Tian Y,Lin J

更新日期：2017-10-01 00:00:00

abstract：:The characteristics of the proliferation of B-cell activating factor (BAFF) and the proliferation-inducing ligand (APRIL) mRNA expression in mononuclear cell in multiple myeloma patients were detected, and the correlation was analyzed between the BAFF and APRIL concentrations in plasma and tumor burden parameters of m...

journal_title：Oncology letters

authors： Pan J,Sun Y,Zhang N,Li J,Ta F,Wei W,Yu S,Ai L

更新日期：2017-09-01 00:00:00

abstract：:The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

journal_title：Oncology letters

authors： Dai S,Xu C,Tian Y,Cheng W,Li B

更新日期：2014-10-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:Approximately 34-86% of neoplasms of the salivary glands are located in the parotid gland and parotidectomy is the first-line treatment for parotid gland tumors. Frey syndrome and cosmetic deformity are common complications experienced by patients following parotidectomy and the sternocleidomastoid muscle flap (SCMF) ...

journal_title：Oncology letters

authors： Liu DY,Tian XJ,Li C,Sun SS,Xiong YH,Zeng XT

更新日期：2013-04-01 00:00:00

abstract：:For osteoblastoma, with its predilection for the spinal column and appendicular skeleton, the skull is an unusual site, and paranasal sinus involvement is very rare. Herein, we report on a case in which the disease was located within the sphenoid bone. To the best of our knowledge, this is the 4th reported case of ost...

journal_title：Oncology letters

authors： Kukwa W,Oziębło A,Oecińska A,Czarnecka AM,Włodarski K,Kukwa A

更新日期：2010-03-01 00:00:00

abstract：:The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...

journal_title：Oncology letters

authors： Yin SP,Gao Y,Xie XS,Xu DD,Riabov V,Du WD

更新日期：2020-03-01 00:00:00

abstract：:Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...

journal_title：Oncology letters

authors： Liu D,Li R,Guo X,Pang L,Zang Y,Liu K,Chen D

更新日期：2018-06-01 00:00:00

abstract：:Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...

journal_title：Oncology letters

authors： Annovazzi L,Mellai M,Bovio E,Mazzetti S,Pollo B,Schiffer D

更新日期：2018-01-01 00:00:00

abstract：:Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...

journal_title：Oncology letters

authors： Liu F,Pan Z,Zhang J,Ni J,Wang C,Wang Z,Gu F,Dong W,Zhou W,Liu H

更新日期：2018-03-01 00:00:00

abstract：:The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18F-FDG PE...

journal_title：Oncology letters

authors： Jiang L,Huang Y,Tang Q,Zhao Q,Li Y,Wu X,Wang H

更新日期：2018-07-01 00:00:00

abstract：:MicroRNAs (miRs) are often located in genomic breakpoint regions and are hypothesized to be important regulators involved in the regulation of critical cell processes, including cell apoptosis, proliferation and differentiation. miR-299 has been reported to be upregulated in acute promyelocytic leukemia (APL); however...

journal_title：Oncology letters

authors： Wu SQ,Zhang LH,Huang HB,Li YP,Niu WY,Zhan R

更新日期：2016-07-01 00:00:00

abstract：:T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell l...

journal_title：Oncology letters

authors： Wu Y,Feng J,Hu W,Zhang Y

更新日期：2017-05-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a common malignancy; however, the majority of its underlying molecular mechanisms remain unknown. In the present study, weighted gene co-expression network analysis was applied to construct gene co-expression networks for the GSE19804 dataset, in order to screen hub genes associated with ...

journal_title：Oncology letters

authors： Yu DH,Huang JY,Liu XP,Ruan XL,Chen C,Hu WD,Li S

更新日期：2020-02-01 00:00:00

abstract：:The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...

journal_title：Oncology letters

authors： Sugiyama T,Iwaizumi M,Kaneko M,Tani S,Yamade M,Hamaya Y,Furuta T,Miyajima H,Osawa S,Baba S,Maekawa M,Sugimoto K

更新日期：2020-09-01 00:00:00

abstract：:Liver cancer, which is the second leading cause of tumor-associated mortality, is of great concern worldwide due to its resistance to chemotherapeutic drugs. Transcatheter arterial chemoembolization (TACE) has previously been used as a treatment for unresectable liver tumors in China; however, the response to TACE tre...

journal_title：Oncology letters

authors： Liu DX,Li PP,Guo JP,Li LL,Guo B,Jiao HB,Wu JH,Chen JM

更新日期：2019-01-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00

abstract：:Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study exami...

journal_title：Oncology letters

authors： Yanai Y,Hayashi T,Akazawa Y,Yatagai N,Tsuyama S,Yao T,Saito T

更新日期：2020-07-01 00:00:00

abstract：:Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...

journal_title：Oncology letters

authors： Cho SG

更新日期：2017-10-01 00:00:00

abstract：:The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DN...

journal_title：Oncology letters

authors： Wang X,Wang H,Bu R,Fei X,Zhao C,Song Y

更新日期：2012-08-01 00:00:00

abstract：:Diffusion weighted imaging (DWI) has been found to increase the sensitivity in the diagnosis of small hepatocellular carcinoma (HCC), although additional studies are required to confirm its value. The aim of the present study was to explore the diagnostic performance of DWI combined with contrast-enhanced magnetic res...

journal_title：Oncology letters

authors： Lan H,Lin G,Zhong W

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined...

journal_title：Oncology letters

authors： Jia Y,Shi H,Fan D

更新日期：2015-07-01 00:00:00

abstract：:Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human e...

journal_title：Oncology letters

authors： Teng C,Li LI,Shen W,Li J,Liu Y,Jiang Q,Xin T,Huang D,Song X,Lv Y,Jin Y

更新日期：2015-08-01 00:00:00

abstract：:Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin-bound paclitaxel (nab-PTX) is a...

journal_title：Oncology letters

authors： Kimura K,Tanaka S,Iwamoto M,Fujioka H,Takahashi Y,Sato N,Terasawa R,Tominaga T,Ikari A,Uchiyama K

更新日期：2013-10-01 00:00:00

abstract：:To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H ...

journal_title：Oncology letters

authors： Wu D,Zeng L,Liu F,Zhong Q,Zhang D,Cai C,Zhang W,Wu L,Chen H

更新日期：2016-12-01 00:00:00

abstract：:AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...

journal_title：Oncology letters

authors： Zhou R,Wu J,Tang X,Wei X,Ju C,Zhang F,Sun J,Shuai D,Zhang Z,Liu Q,Lv XB

更新日期：2018-08-01 00:00:00