Abstract:
:T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell lung cancer (NSCLC) are unknown. To the best of our knowledge, the present study provided the first evidence demonstrating the clinicopathological significance of Tbx3 in NSCLC. Tbx3 was revealed to be overexpressed in NSCLC cell lines and tissues obtained from patients with NSCLC by reverse transcription-quantitative polymerase chain reaction and western blot analysis. Downregulation of Tbx3 by Tbx3-specific short hairpin RNA decreased cell proliferation in NSCLC cell lines, but there was a slight increase in the cell population of the G1 phase. Furthermore, depletion of Tbx3 expression significantly decreased the cell migration distance. In addition, overexpression of Tbx3 was notably associated with tumor size, tobacco smoking status, tumor-node-metastasis stage and differentiation. These results demonstrated the importance of Tbx3 in the pathological progression of NSCLC and may serve as a potential therapeutic target for NSCLC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wu Y,Feng J,Hu W,Zhang Ydoi
10.3892/ol.2017.5855subject
Has Abstractpub_date
2017-05-01 00:00:00pages
3335-3341issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-5855journal_volume
13pub_type
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