Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue.


:When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic predictors that have an association with HCC background non-tumorous tissue. Microarray expression profiling identified aldo-keto reductase family 1, member B10 (AKR1B10) as a putative non-tumorous prognostic factor, and AKR1B10 gene expression was investigated in 158 curatively resected HCC cases by reverse transcription-quantitative polymerase chain reaction. AKR1B10 expression (AKR1B10 value/GAPDH value × 1,000) was significantly higher in tumor tissue (median, 9.2200; range, 0.0003-611.0200; n=158) than in the corresponding non-tumorous tissue (median, 0.5461; range, 0.0018-69.0300; n=158) (P<0.001). When the samples were grouped according to AKR1B10 expression in tumor tissue relative to non-tumorous tissue, tumor


Oncol Lett


Oncology letters


Sonohara F,Inokawa Y,Hishida M,Kanda M,Nishikawa Y,Yamada S,Fujii T,Sugimoto H,Kodera Y,Nomoto S




Has Abstract


2016-12-01 00:00:00














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    abstract::Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Xu X,Cao L,Zhang Y,Lian H,Sun Z,Cui Y

    更新日期:2018-12-01 00:00:00

  • Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.

    abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Ni L,Li C,Li Y

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  • Downregulation of ST3GAL5 is associated with muscle invasion, high grade and a poor prognosis in patients with bladder cancer.

    abstract::In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade and prognosis, remain unknown. In the present study, the expression of ST3GAL5 and its association with ...

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    authors: Ouyang S,Liu JH,Ni Z,Ding GF,Wang QZ

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  • Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21.

    abstract::Nordihydroguaiaretic acid (NDGA) and its derivatives possess anti-cancer effects on various types of cancer via the induction of apoptosis or cell cycle arrest. This study proved that NDGA inhibited cervical cancer SiHa cell growth and induced cell cycle arrest at the G(1) phase, which may be a consequence of cell cyc...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Gao P,Zhai F,Guan L,Zheng J

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  • The role of the retinoblastoma protein-interacting zinc finger gene 1 tumor suppressor gene in human esophageal squamous cell carcinoma cells.

    abstract::The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...

    journal_title:Oncology letters

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    authors: Dong S,Zhang P,Liang S,Wang S,Sun P,Wang Y

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  • Clinicopathological and mutational differences between tumors with multiple metastases and single lung metastasis in colorectal cancer.

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    journal_title:Oncology letters

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    authors: Yanai Y,Hayashi T,Akazawa Y,Yatagai N,Tsuyama S,Yao T,Saito T

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  • MicroRNA-125a-3p downregulation correlates with tumorigenesis and poor prognosis in patients with non-small cell lung cancer.

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    journal_title:Oncology letters

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    authors: Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

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  • Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Morimoto M,Aikawa K,Hara T,Yamaoka M

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  • Analysis of soluble urokinase plasminogen activator receptor in multiple myeloma for predicting prognosis.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Shen J,Wang Q,Wang J,Su GH,Wang J,Guo SH,Liu YA,Wu Z,Liu RF,Li X,Guo XJ,Cao J,Zhang YH,Wang ZY

    更新日期:2015-10-01 00:00:00

  • Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer.

    abstract::Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia te...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao X,Zhao J,Hu R,Yao Q,Zhang G,Shen H,Yagüe E,Hu Y

    更新日期:2017-05-01 00:00:00

  • Goiter and hearing impairment: A case of a male patient with Pendred syndrome.

    abstract::Pendred syndrome is a rare genetic disease that causes a disturbance in thyroid hormone synthesis, which results in thyroid dysfunction and the development of goiter and sensorineural deafness. The present report describes the case of a young euthyroid male, who developed a large goiter and hearing impairment, despite...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hu EW,Liu LB,Jiang RY,He XH

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  • Hyperthermia and radiation reduce the toxic side-effects of bufadienolides for cancer therapy.

    abstract::Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

    更新日期:2017-07-01 00:00:00

  • Construction of recombinant pEGFP-N1-hPer2 plasmid and its expression in osteosarcoma cells.

    abstract::The aim of this study was to construct the eukaryotic expression vector pEGFP-N1-hPer2 and assess its expression in the human osteosarcoma cell line MG63. Total mRNA was extracted from human osteosarcoma MG63 cells, the human period 2 (hPer2) gene was obtained by reverse transcription-polymerase chain reaction (RT-PCR...

    journal_title:Oncology letters

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    authors: Cheng A,Zhang Y,Mei H,Fang S,Ji P,Yang J,Yu L,Guo W

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  • Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination.

    abstract::The present study analyzed polymorphisms of the 5' flanking region (from nt -840 to +151) of the haptoglobin gene in 120 patients with advanced non-small cell lung cancer (NSCLC) receiving personalized peptide vaccinations. In the region, six single nucleotide polymorphisms (SNPs) were confirmed, of which two, rs5472 ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Waki K,Yamada T,Yoshiyama K,Terazaki Y,Sakamoto S,Sugawara S,Takamori S,Itoh K,Yamada A

    更新日期:2017-02-01 00:00:00

  • Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions.

    abstract::It has been reported that zerumbone (ZER) has marked effects on the regulation of cell proliferation and migration in multiple types of cancer, and has anti-cancer effects on various types of malignant cell. However, the effects and underlying molecular mechanisms of treatment with ZER on melanoma cells remain unclear...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan H,Ren MY,Wang ZX,Feng SJ,Li S,Cheng Y,Hu CX,Gao SQ,Zhang GQ

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  • Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases.

    abstract::Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Morimoto T,Takenaka S,Hashimoto N,Araki N,Myoui A,Yoshikawa H

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  • Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells.

    abstract::A promising nutraceutical, apigenin, was recently revealed to exhibit biological activity in inhibiting several types of cancer. The effects of apigenin on the growth inhibition and apoptosis of the cholangiocarcinoma HuCCA-1 cell line were investigated. Protein alterations subsequent to apigenin treatment were studie...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Keeratichamroen S,Ngiwsara L,Paricharttanakul NM,Lirdprapamongkol K,Weeraphan C,Svasti J,Srisomsap C

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  • Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao X,Wang N,Zhang M,Xue S,Shi K,Chen Z

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  • Tumor infiltrating lymphocytes: The regulator of melanoma evolution.

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    journal_title:Oncology letters

    pub_type: 杂志文章,评审


    authors: Antohe M,Nedelcu RI,Nichita L,Popp CG,Cioplea M,Brinzea A,Hodorogea A,Calinescu A,Balaban M,Ion DA,Diaconu C,Bleotu C,Pirici D,Zurac SA,Turcu G

    更新日期:2019-05-01 00:00:00

  • Altered expression of microRNA-92b-3p predicts survival outcomes of patients with prostate cancer and functions as an oncogene in tumor progression.

    abstract::The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...

    journal_title:Oncology letters

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    authors: Wang G,Cheng B,Jia R,Tan B,Liu W

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  • Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma.

    abstract::Glutathione transferase Mu 1 (GSTM1) induces cancer drug resistance by hydrolyzing cancer chemotherapeutics or activating the anti-apoptosis pathway. However, the chemoresistance-inducing mechanism of GSTM1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, the expression of GSTM1 was examined in...

    journal_title:Oncology letters

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    authors: Fu XT,Song K,Zhou J,Shi YH,Liu WR,Tian MX,Jin L,Shi GM,Gao Q,Ding ZB,Fan J

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  • RASEF expression correlates with hormone receptor status in breast cancer.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Shibata M,Kanda M,Shimizu D,Tanaka H,Umeda S,Miwa T,Hayashi M,Inaishi T,Miyajima N,Adachi Y,Takano Y,Nakanishi K,Takeuchi D,Noda S,Kodera Y,Kikumori T

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  • Clinical predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer.

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    journal_title:Oncology letters

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    authors: Nakashoji A,Matsui A,Nagayama A,Iwata Y,Sasahara M,Murata Y

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  • Prognostic analysis of triple-negative breast cancer patients treated with adjuvant chemotherapy of fluorouracil, epirubicin and cyclophosphamide.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Sun W,Li C,Liu M,Liu W,Yang C,Cai LI

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  • Relationship between CT signs and the expression of miR-146a in colon cancer.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu Z,Li Y,Luo Q

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  • Effect of apigenin on whole transcriptome profile of TNFα-activated MDA-MB-468 triple negative breast cancer cells.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Bauer D,Mazzio E,Hilliard A,Oriaku ET,Soliman KFA

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhang G,Gao X,Zeng H,Li Y,Guo X

    更新日期:2018-01-01 00:00:00

  • Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liang L,Zeng M,Pan H,Liu H,He Y

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  • Collecting duct carcinoma of the kidney: Imaging observations of a rare tumor.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

    更新日期:2014-02-01 00:00:00