Multicomponent nutritional supplement Oncoxin and its influence on quality of life and therapy toxicity in patients receiving adjuvant chemotherapy.

abstract：:Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...

journal_title：Oncology letters

authors： Xie J,Lin W,Huang L,Xu N,Xu A,Chen B,Watanabe M,Liu C,Huang P

更新日期：2018-09-01 00:00:00

abstract：:The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...

journal_title：Oncology letters

authors： Murakami M,Ichimura T,Kasai M,Matsuda M,Kawamura N,Fukuda T,Sumi T

更新日期：2018-06-01 00:00:00

abstract：:Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...

journal_title：Oncology letters

authors： Xie H,Lu Q,Wang H,Zhu X,Guan Z

更新日期：2019-01-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasi...

journal_title：Oncology letters

authors： Fang Y,Qiu J,Jiang ZB,Xu SR,Zhou ZH,He RL

更新日期：2019-01-01 00:00:00

abstract：:microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

journal_title：Oncology letters

authors： Li L,Jia L,Ding Y

更新日期：2018-09-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00

abstract：:Transcription factors encoded by HOX genes are vital in the determination of cell fate and identity during embryonic development. In certain malignancies, HOX genes also behave as oncogenes. The present study demonstrated suppression of the invasive tendency of glioblastoma multiforme U-118 and U-138 cells by the intr...

journal_title：Oncology letters

authors： Guo YB,Shao YM,Chen J,Xu SB,Zhang XD,Wang MR,Liu HY

更新日期：2016-01-01 00:00:00

abstract：:The monolocular cystic formation associated with gallbladder carcinoma is an extremely rare condition. A 79-year-old female suffering from upper abdominal pain and distention was admitted to our hospital. Ultrasonography and computed tomography revealed a monolocular cyst with an irregular wall thickness of 15 cm in d...

journal_title：Oncology letters

authors： Hiraki M,Yakushiji H,Hashiguchi K,Harada S,Kohya N,Kai K,Yamaguchi K,Mori D,Irie K,Tokunaga O,Noshiro H,Miyazaki K

更新日期：2010-11-01 00:00:00

abstract：:MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...

journal_title：Oncology letters

authors： Palkina N,Komina A,Aksenenko M,Moshev A,Savchenko A,Ruksha T

更新日期：2018-06-01 00:00:00

abstract：:The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...

journal_title：Oncology letters

authors： Parikh JG,Kulkarni A,Johns C

更新日期：2014-02-01 00:00:00

abstract：:Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL...

journal_title：Oncology letters

authors： Shimaoka H,Takeno S,Maki K,Sasaki T,Hasegawa S,Yamashita Y

更新日期：2017-09-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, and has high incidence and mortality rates, worldwide. Myelodysplastic syndrome (MDS), a disorder of hematopoietic stem or progenitor cells, results in marrow failure, which increases the risk of acute myeloid leukemia (AML). Few stu...

journal_title：Oncology letters

authors： Liu L,Liu X,Sun Y,Zeng Y,Tang X,Li X,Liu J,Xiao R

更新日期：2020-11-01 00:00:00

abstract：:Gastric cancer is a pathological process of an accumulation of multigene and multistage mutations. A new gene segment, MDSCBC11, has been previously obtained using a gene chip and is negatively associated with gastric cancer. The present study aimed to clone the full cDNA sequence of the MDSCBC11 segment and to detect...

journal_title：Oncology letters

authors： Gan R,Liu X,Zhou Y,Tan Y,Liu H,Li G,Tang Y,Xie H

更新日期：2013-12-01 00:00:00

abstract：:The present study investigated the anticancer functions of ursolic acid (UA) and its novel derivatives, with a nitrogen-containing heterocyclic scaffold and the privileged fragment at the C-28 position on apoptosis induction, cell proliferation and cell cycle in human BC lines. UA was chemically modified in the presen...

journal_title：Oncology letters

authors： Li W,Zhang H,Nie M,Wang W,Liu Z,Chen C,Chen H,Liu R,Baloch Z,Ma K

更新日期：2018-02-01 00:00:00

abstract：:Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...

journal_title：Oncology letters

authors： Xu X,Wu J,Ren G,Hu Q

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive ...

journal_title：Oncology letters

authors： Sun G,Xing W,Xing R,Cong L,Tong S,Yu S

更新日期：2018-02-01 00:00:00

abstract：:Changes in the expression of regulator of G protein signaling 2 (RGS2) are involved in the genesis and development of a number of malignancies. However, the association between changes in the expression of RGS2 and breast invasive carcinoma of no special type (BIC-NST) remains unknown. The present study found that, in...

journal_title：Oncology letters

authors： Wang C,Ye Q,Cao Y,Tan J,Wang F,Jiang J,Cao Y

更新日期：2018-01-01 00:00:00

abstract：:Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...

journal_title：Oncology letters

authors： Matsuda Y,Fujii Y,Matsukawa M,Ishiwata T,Nishimura M,Arai T

更新日期：2019-10-01 00:00:00

abstract：:The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as signi...

journal_title：Oncology letters

authors： Yu X,Li Z

更新日期：2015-10-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain c...

journal_title：Oncology letters

authors： Zhao Y,Wang Y,Wu X,Wang J,Zhang L,Jia Y,Qi W

更新日期：2016-01-01 00:00:00

abstract：:Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...

journal_title：Oncology letters

authors： Pan X,Yang X,Zang J,Zhang S,Huang N,Guan X,Zhang J,Wang Z,Li X,Lei X

更新日期：2017-06-01 00:00:00

abstract：:The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...

journal_title：Oncology letters

authors： Dong S,Zhang P,Liang S,Wang S,Sun P,Wang Y

更新日期：2013-12-01 00:00:00

abstract：:The use of 5α-reductase inhibitors (5α-RIs) as prostate cancer chemoprevention agents is controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial, have both shown a decreased incidence of prostate cancer in patient...

journal_title：Oncology letters

authors： Lacy JM,Kyprianou N

更新日期：2014-10-01 00:00:00

abstract：:The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...

journal_title：Oncology letters

authors： Chen D,Mei L,Zhou Y,Shen C,Xu H,Niu Z,Che G

更新日期：2015-03-01 00:00:00

abstract：:KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...

journal_title：Oncology letters

authors： Pelliccia F,Ubertini V,Bosco N

更新日期：2012-08-01 00:00:00

abstract：:The concentrations required for curcumin to exert its anticancer activity (IC50, 20 µM) are difficult to achieve in the blood plasma of patients, due to the low bioavailability of the compound. Therefore, much effort has been devoted to the development of curcumin analogues that exhibit stronger anticancer activity an...

journal_title：Oncology letters

authors： Zhou DY,Zhao SQ,DU ZY,Zheng XI,Zhang K

更新日期：2016-06-01 00:00:00

abstract：:Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...

journal_title：Oncology letters

authors： Jiang L,Liu M,Cai X,Xie L,She F,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allogra...

journal_title：Oncology letters

authors： Lin C,Yang JS,Tsai SC,Lin CF,Lee MR

更新日期：2013-03-01 00:00:00

abstract：:MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

journal_title：Oncology letters

authors： Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...

journal_title：Oncology letters

authors： Guo E,Wei H,Liao X,Xu Y,Li S,Zeng X

更新日期：2018-04-01 00:00:00