Abstract:
:MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted in a decrease or increase, respectively, in melanoma cell proliferation and colony formation. miR-204-5p mimics hindered invasion, whereas miR-204-5p inhibitors stimulated cancer cell migration. Modulation of miR-3065-5p led to a decrease in melanoma cell proliferation, altered cell cycle distribution and increased expression levels of its target genes HIPK1 and ITGA1, possibly due to functional modifications identified in these cells. miR-204-5p and miR-3065-5p demonstrated antitumor capacities that may need to be taken into account in the development of melanoma treatment approaches.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Palkina N,Komina A,Aksenenko M,Moshev A,Savchenko A,Ruksha Tdoi
10.3892/ol.2018.8443subject
Has Abstractpub_date
2018-06-01 00:00:00pages
8269-8280issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-8443journal_volume
15pub_type
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