Abstract:
:WNT1-inducible-signaling pathway protein-1 (WISP-1) belongs to the family of cysteine rich 61/connective tissue growth factor/nephroblastoma overexpressed matricellular proteins, which are involved in various biological processes, including cell adhesion, proliferation, differentiation, angiogenesis and carcinogenesis. In the present study, the expression of WISP-1 was investigated, and its association with clinicopathological factors and prognosis in patients with oral squamous cell carcinoma (OSCC) was evaluated. Additionally, the role of WISP-1 in invasion and apoptosis of human OSCC cells was evaluated. Immunoreactivity of WISP-1 was increased in OSCC tissue compared with adjacent normal tissue samples. High expression of WISP-1 protein was observed in 24/84 (28.57%) OSCC specimens. Additionally, high WISP-1 expression was significantly associated with treatment failure (P=0.042). The 5-year overall survival rate was 33% in patients with high WISP1 expression, and 66% in patients with low WISP-1 expression. WISP-1 expression in the human OSCC SCC-1483 cell line was observed. Furthermore, WISP-1 knockdown using small interfering (si)RNA significantly reduced cell invasion and induced apoptosis compared with control siRNA-transfected cells. These findings suggested that WISP-1 is associated with tumor progression and poor prognosis by increasing tumor cell invasion and inhibiting cell apoptosis in human OSCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jung EK,Kim SA,Yoon TM,Lee KH,Kim HK,Lee DH,Lee JK,Chung IJ,Joo YE,Lim SCdoi
10.3892/ol.2017.6313subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1719-1724issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-6313journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. Pancreatic carcinoma is one of the most malignant human cancer type...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7178
更新日期:2017-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in the insulin-like growth factor-1 (IGF-1) receptor signalling pathway during experimental hepatocarcinogenesis. The aim of this study was ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.546
更新日期:2012-03-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4760
更新日期:2016-08-01 00:00:00
abstract::The Janus kinase (JAK)2 gene, which is located on chromosome 9p24, is involved in the signaling transduction pathways of the hematopoietic and immune system. Mutations in the JAK2 gene have served as disease markers for myeloproliferative neoplasms (MPNs). The aim of the present study was to investigate the occurrence...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2801
更新日期:2015-02-01 00:00:00
abstract::Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000137
更新日期:2010-09-01 00:00:00
abstract::Diffusion weighted imaging (DWI) has been found to increase the sensitivity in the diagnosis of small hepatocellular carcinoma (HCC), although additional studies are required to confirm its value. The aim of the present study was to explore the diagnostic performance of DWI combined with contrast-enhanced magnetic res...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11805
更新日期:2020-09-01 00:00:00
abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5572
更新日期:2017-03-01 00:00:00
abstract::The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.361
更新日期:2011-09-01 00:00:00
abstract::Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog (PT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8626
更新日期:2018-07-01 00:00:00
abstract::In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2910
更新日期:2015-04-01 00:00:00
abstract::The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had os...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6939
更新日期:2017-11-01 00:00:00
abstract::The current report presents the case of a 41-year-old male exhibiting a giant cell tumor of the tendon sheath (GCT-TS) arising from the patellar tendon sheath. Plain radiography and magnetic resonance imaging revealed a well-localized mass that wrapped around the patellar tendon, and extended from the subcutis into th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2561
更新日期:2014-12-01 00:00:00
abstract::The Notch signaling pathway has been shown to be involved in the progression of chronic myeloid leukemia (CML). The aim of this study was to investigate the effects of exogenous Notch2 overexpression on cell proliferation and possible mechanisms in the human CML cell line K562. When exogenous intracellular fragment of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1159
更新日期:2013-04-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8771
更新日期:2018-07-01 00:00:00
abstract::Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10402
更新日期:2019-08-01 00:00:00
abstract::Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3848
更新日期:2016-01-01 00:00:00
abstract::The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3515
更新日期:2015-10-01 00:00:00
abstract::A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, part...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7742
更新日期:2018-03-01 00:00:00
abstract::Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10737
更新日期:2019-10-01 00:00:00
abstract::The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2826
更新日期:2015-03-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4887
更新日期:2016-09-01 00:00:00
abstract::Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8051
更新日期:2018-04-01 00:00:00
abstract::The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8836
更新日期:2018-08-01 00:00:00
abstract::The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1072
更新日期:2013-02-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10382
更新日期:2019-07-01 00:00:00
abstract::Metastatic spread of gastric carcinoma to the breast is rare. In previous decades, reports on this subject were minimal and primarily limited to case reports. At present, little is known on the clinicopathological features and prognosis of this condition, and breast metastasis remains a challenging clinical problem. A...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9383
更新日期:2018-11-01 00:00:00
abstract::The outcomes of matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) remain controversial. The clinical outcome in patients that undergo transplantation following failed IST is typically poorer when compared with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2341
更新日期:2014-10-01 00:00:00
abstract::Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2920
更新日期:2015-04-01 00:00:00