Abstract:
:Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathological features using immunohistochemistry in 94 NSCLC cases, as well as proliferation in cells with aberrant expression of this protein. Overexpression of CD44 was achieved by transfecting H1299 cells with CD44 expression vectors, and inhibition of CD44 expression was performed by transfecting small interfering RNAs into A549 cells. Cell proliferation was measured using Cell Counting Kit-8 assays and flat plate colony formation assay was performed to confirm the cellular anchorage growth in vitro. In total, 64 (68.1%) of the 94 NSCLC cases stained positive for CD44 expression. High expression of CD44 was associated with advanced T stage in NSCLC. Overexpression of CD44 in H1299 cells promoted cell proliferation and colony formation in vitro. Meanwhile, knockdown of CD44 expression in A549 cells suppressed cell proliferation and colony formation in vitro. High expression of CD44 may promote NSCLC progression by increasing cancer cell proliferation; therefore, it may serve as a potential biomarker for diagnosis or target therapy.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Hu B,Ma Y,Yang Y,Zhang L,Han H,Chen Jdoi
10.3892/ol.2018.8051subject
Has Abstractpub_date
2018-04-01 00:00:00pages
5627-5633issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-8051journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Although there is evidence that galectin-9 is a critical factor in health and disease, the upstream regulatory microRNA (miRNA or miR) of the protein remains poorly defined. miR-455-5p is characterized as a tumor-associated miRNA in cancer research. However, the actual role of miR-455-5p with respect to inhibiting or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5608
更新日期:2017-03-01 00:00:00
abstract::The aim of the present study was to determine the impact of obesity on radiation-induced gastrointestinal (GI) and genitourinary (GU) toxicity. The cases of 54 patients with prostate cancer, treated with three-dimensional conformal radiation therapy (RT), were reviewed. For each patient, the body mass index (BMI), dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1658
更新日期:2014-01-01 00:00:00
abstract::While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11663
更新日期:2020-08-01 00:00:00
abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9322
更新日期:2018-10-01 00:00:00
abstract::We compared the clinical effects and prognosis of patients receiving lymph node dissection after surgical removal of the thyroid tissues and those not receiving it after the removal. A total of 80 patients diagnosed with differentiated thyroid carcinoma (DTC) by our hospital from March 2012 to March 2014 were successi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5450
更新日期:2017-01-01 00:00:00
abstract::The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6692
更新日期:2017-10-01 00:00:00
abstract::Carbon dioxide (CO2) laser ablation in combination with photodynamic therapy (PDT) has previously been successfully used to treat superficial basal cell carcinoma (BCC). However, the efficacy of this treatment modality is limited in the treatment of deeper lesions and the more aggressive subtypes of BCC. In order to i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1504
更新日期:2013-10-01 00:00:00
abstract::The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3519
更新日期:2015-10-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8472
更新日期:2018-06-01 00:00:00
abstract::Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10814
更新日期:2019-11-01 00:00:00
abstract::Gemcitabine (GCB), which functions via the inhibition of DNA synthesis, is commonly used in the treatment of bladder cancer; however, its response rate is not satisfactory due to the development of drug resistance. The potential for phytochemicals to reverse drug resistance in bladder cancer tumor cells was evaluated....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11023
更新日期:2019-12-01 00:00:00
abstract::Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.765
更新日期:2012-09-01 00:00:00
abstract::Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6926
更新日期:2017-11-01 00:00:00
abstract::The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5-7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells with AnnexinV/propidi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10341
更新日期:2019-07-01 00:00:00
abstract::The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.497
更新日期:2012-02-01 00:00:00
abstract::A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, part...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7742
更新日期:2018-03-01 00:00:00
abstract::The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10016
更新日期:2019-04-01 00:00:00
abstract::The present study investigated the effects of N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, on the growth of gliomas. To analyze the effects of ketamine treatment, rat C6 glioma cells arising from astrocytes, and RNB cells representing non-malignant astrocytes, were examined. In ketamine-treated C6 cells,...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6806
更新日期:2017-10-01 00:00:00
abstract::Skeletal muscle is rich in lymphatic vessels, with an abundant blood supply, and it is an infrequent site of cancer metastasis. Previous studies have demonstrated that enhanced secretion of MyoD may occur when skeletal muscle is injured or becomes cancerous. It was hypothesized that MyoD may act as an endogenous cytok...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4448
更新日期:2016-06-01 00:00:00
abstract::Secretory breast carcinoma is a very rare and distinct subtype of breast cancer, characterized by the presence of intracellular and extracellular secretory material. Secretory breast carcinoma has a good clinical outcome and systemic involvement is rare. The majority of studies of this tumor have been case reports or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2213
更新日期:2014-08-01 00:00:00
abstract::Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9085
更新日期:2018-09-01 00:00:00
abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1725
更新日期:2014-02-01 00:00:00
abstract::The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.361
更新日期:2011-09-01 00:00:00
abstract::Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient's native joint function becomes signif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1036
更新日期:2013-02-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer worldwide. However, operative diagnostic and prognostic systems for ESCC remain to be established. To improve assessment of the prognosis for patients with ESCC, the present study developed an online consensus survival tool for ESCC, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10440
更新日期:2019-08-01 00:00:00
abstract::It is well-known that tumor angiogenesis is important in cancer development, and studies on blocking angiogenesis to treat tumors have become one of the most promising and active fields in anticancer research. The present study investigated the effect of siRNA targeting the tyrosine kinase receptor 2 (Tie2) gene in co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1295
更新日期:2013-06-01 00:00:00
abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.644
更新日期:2012-06-01 00:00:00
abstract::Percutaneous transluminal angioplasty using balloon catheters for Budd-Chiari syndrome (BCS) and transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (HCC) have become increasingly accepted as alternative therapeutic modalities. However, few studies have investigated the clinical e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1417
更新日期:2013-08-01 00:00:00
abstract::Hyperbaric oxygenation (HBO) on postoperative rehabilitation of brain tumors and effects on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were explored. A retrospective analysis of 132 patients with brain tumors treated in the People's Hospital of Rizhao from October 2014 to October 2017 was performe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10000
更新日期:2019-03-01 00:00:00
abstract::Toll-like receptor 4 (TLR4) and the interleukin (IL)-23/IL-17A axis serve an important role in tumor immunology. In the present study, the activation of the TLR4/myeloid differentiation primary response 88 (MyD88)-mediated signal transduction pathway in human hepatocellular carcinoma (HCC) cells was examined using imm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8586
更新日期:2018-06-01 00:00:00