Co-activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer.

abstract：:The present study reported three rare cases of multicystic vestibular schwannoma with fluid-fluid levels. These three tumors exhibited apparent fluid-fluid levels that demonstrated a radiological appearance of two fluid levels in the cystic area. Two cases had an acute history, whereas one case presented with a chroni...

journal_title：Oncology letters

authors： Li P,Bi Z,Hao S,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downreg...

journal_title：Oncology letters

authors： Niu L,Liu A,Xu W,Yang L,Zhu W,Gu Y

更新日期：2018-10-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...

journal_title：Oncology letters

authors： Yang J,Ma JP,Xiao S,Zhang XH,Xu JB,Chen CQ,Cai SR,He YL

更新日期：2018-05-01 00:00:00

abstract：:Atorvastatin (ATST), a drug commonly used to reduce the levels of cholesterol and low-density lipoproteins, is a prospective agent for the prevention of colorectal cancer in patients with hyperlipidemia. ATST in combination with functional components is a promising strategy for cancer chemoprevention. In the present s...

journal_title：Oncology letters

authors： Zhou M,Zheng J,Bi J,Wu X,Lyu J,Gao K

更新日期：2018-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fr...

journal_title：Oncology letters

authors： Ahmed K,Zaidi SF,Cui ZG,Zhou D,Saeed SA,Inadera H

更新日期：2019-07-01 00:00:00

abstract：:N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in hepatocellular carcinoma (HCC) cells remains controversial. The present study investigated the role of NDRG1 in HCC as well as its molecular mechanism using a range of t...

journal_title：Oncology letters

authors： Song Y,Wu G,Zhang M,Kong Q,Du J,Zheng Y,Yue L,Cao L

更新日期：2017-05-01 00:00:00

abstract：:Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...

journal_title：Oncology letters

authors： Jia Z,Zhang Y,Xu Q,Guo W,Guo A

更新日期：2018-05-01 00:00:00

abstract：:This study investigated the inhibitory effect of vitamin D-binding protein-derived macrophage-activating factor (GcMAF) on carcinogenesis and tumor growth, using a 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster cheek pouch carcinogenesis model, as well as the cytocidal effect of activated macrophages against ...

journal_title：Oncology letters

authors： Toyohara Y,Hashitani S,Kishimoto H,Noguchi K,Yamamoto N,Urade M

更新日期：2011-07-01 00:00:00

abstract：:MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell pro...

journal_title：Oncology letters

authors： Hou Y

更新日期：2019-01-01 00:00:00

abstract：:To define the correlation between BCR promoter DNA methylation and response to imatinib in chronic myeloid leukemia (CML), we investigated BCR promoter DNA methylation in three groups of subjects. The first group included chronic phase patients enrolled in an imatinib dose escalation trial. In the trial, patients who ...

journal_title：Oncology letters

authors： Koh Y,Kim DY,Park SH,Byun HM,Kim I,Yoon SS,Kim BK,Park E,Yang AS,Park S

更新日期：2011-01-01 00:00:00

abstract：:The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...

journal_title：Oncology letters

authors： Zhang Z,Zou J,Li Y,Liu Z,Xu R,Tian W,Zhao Z,Sun H,Han J,Wang J,Zhang B,Ju Y

更新日期：2015-05-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...

journal_title：Oncology letters

authors： Chai HJ,Ren Q,Fan Q,Ye L,Du GY,Du HW,Xu W,Li Y,Zhang L,Cheng ZP

更新日期：2017-11-01 00:00:00

abstract：:Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it unsuitable for operative surgery, and resistant to chemotherapy and radiation therapy. Isochorismatase domain-containing protein 1 (ISOC1) has putative isochorismatase act...

journal_title：Oncology letters

authors： Cheng L,Zhao Y,Tang M,Luo Z,Wang X

更新日期：2019-05-01 00:00:00

abstract：:Although there is evidence that galectin-9 is a critical factor in health and disease, the upstream regulatory microRNA (miRNA or miR) of the protein remains poorly defined. miR-455-5p is characterized as a tumor-associated miRNA in cancer research. However, the actual role of miR-455-5p with respect to inhibiting or ...

journal_title：Oncology letters

authors： Yang Q,Hou C,Huang D,Zhuang C,Jiang W,Geng Z,Wang X,Hu L

更新日期：2017-03-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...

journal_title：Oncology letters

authors： He J,Mu M,Luo Y,Wang H,Ma H,Guo S,Fang Q,Qian Z,Lu H,Song C

更新日期：2019-03-01 00:00:00

abstract：:Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic mar...

journal_title：Oncology letters

authors： Zhong P,Liu L,Shen A,Chen Z,Hu X,Cai Y,Lin J,Wang B,Li J,Chen Y,Peng J

更新日期：2019-12-01 00:00:00

abstract：:Numerous studies concerning hepatic arterial infusion chemotherapy (HAIC) have been conducted by adopting regimens containing 5-fluorouracil (FU), with a favourable efficacy compared with conventional transcatheter arterial chemoembolisation (TACE) treatment; however, the detailed mechanism of HAIC remains unclear. Th...

journal_title：Oncology letters

authors： Gao J,Zhen R,Liao H,Zhuang W,Guo W

更新日期：2018-05-01 00:00:00

abstract：:Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...

journal_title：Oncology letters

authors： Li H,Zhang H,Zhao S,Shi Y,Yao J,Zhang Y,Guo H,Liu X

更新日期：2015-05-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00

abstract：:Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...

journal_title：Oncology letters

authors： Shen A,Ma J,Hu X,Cui X

更新日期：2020-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...

journal_title：Oncology letters

authors： Zou Z,Gan S,Liu S,Li R,Huang J

更新日期：2019-07-01 00:00:00

abstract：:Ascorbic acid (A) has been demonstrated to exhibit anti-cancer activity in association with chemotherapeutic agents. Potassium (K) is a regulator of cellular proliferation. In the present study, the biological effects of A and K bicarbonate, alone or in combination (A+K), on breast cancer cell lines were evaluated. Th...

journal_title：Oncology letters

authors： Frajese GV,Benvenuto M,Fantini M,Ambrosin E,Sacchetti P,Masuelli L,Giganti MG,Modesti A,Bei R

更新日期：2016-06-01 00:00:00

abstract：:Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the...

journal_title：Oncology letters

authors： Yue WJ,Liu YP,Li M,Liu CX,Mou SJ,Li QK,Chen ZP

更新日期：2018-10-01 00:00:00

abstract：:Solanine is an alkaloid and is the main extract of the traditional Chinese herb, Solanum nigrum Linn. It has been reported that Solanine has anti-inflammatory and antitumor properties. The present study aimed to investigate the antitumor effect of Solanine in Jurkat cells and demonstrate the molecular mechanism of ant...

journal_title：Oncology letters

authors： Yi YJ,Jia XH,Wang JY,Chen JR,Wang H,Li YJ

更新日期：2018-05-01 00:00:00

abstract：:Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...

journal_title：Oncology letters

authors： Sui Y,Li J,Zou Z,Shi Y,Hao C

更新日期：2019-06-01 00:00:00

abstract：:Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in the formation and development of human tumors, including cervical cancer. Previous studies have indicated that FOXM1 may be a downstream target gene of the Hh signaling pathway, but their association in cervical cancer is largely unknown. In...

journal_title：Oncology letters

authors： Chen H,Wang J,Yang H,Chen D,Li P

更新日期：2016-10-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...

journal_title：Oncology letters

authors： Tang H,Xu L,Liang X,Gao G

更新日期：2018-11-01 00:00:00

abstract：:A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...

journal_title：Oncology letters

authors： Suciu C,Muresan A,Cornea R,Suciu O,Dema A,Raica M

更新日期：2014-01-01 00:00:00

abstract：:Bone metastasis is an uncommon event in advanced gastric cancer patients and bone metastases are rarely detected as isolated lesions. However, eleven years after treatment for locally advanced gastric cancer, including total gastrectomy followed by adjuvant chemotherapy, a 49-year-old female was admitted to the IX Div...

journal_title：Oncology letters

authors： Iovino F,Orditura M,Auriemma PP,Ciorra FR,Giordano G,Orabona C,Bara F,Sergio R,Savastano B,Fabozzi A,Laterza MM,Ventriglia J,Petrillo A,Della Corte CM,DE Vita F

更新日期：2015-03-01 00:00:00