Abstract:
:Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the potential of ephrin-B2 as a therapeutic target remains unknown. The present study investigated ephrin-B2 as a prognostic factor and a therapeutic target for gastric cancer. Reverse transcription-quantitative polymerase chain reaction was performed to detect the protein expression level of ephrin-B2 in gastric cancer serum samples (n=162) and healthy serum samples (n=165). It was revealed that the protein expression level of ephrin-B2 was significantly upregulated in gastric cancer serum samples compared with the healthy samples. Ephrin-B2 protein expression was associated with tumor size (P<0.001), metastasis (P=0.02) and TNM stage (P=0.03), and was indicated to be an independent prognostic factor for gastric cancer. Furthermore, the Kaplan-Meier survival curve demonstrated that patients with high ephrin-B2 protein expression had shorter overall and progression-free survival rates than those with low ephrin-B2 protein expression. Ephrin-B2 protein expression was induced by small interfering RNA (siRNA) transfection of HGC27 and MKN-45 cells, significantly impeding cell viability and inducing apoptosis of HGC27 and MKN-45 cells compared with the respective negative control (NC) group. Thus, to the best of our knowledge, the present study indicates that ephrin-B2 functions as an oncogene in gastric cancer, and that serum ephrin-B2 level may be a promising non-invasive prognostic indicator, as well as a therapeutic target for gastric cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Yue WJ,Liu YP,Li M,Liu CX,Mou SJ,Li QK,Chen ZPdoi
10.3892/ol.2018.9202subject
Has Abstractpub_date
2018-10-01 00:00:00pages
4455-4461issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-9202journal_volume
16pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5220
更新日期:2016-12-01 00:00:00
abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.603
更新日期:2012-05-01 00:00:00
abstract::In the present study, the anti-tumor effects of combination treatment with an siRNA targeting B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E and phosphoinositide 3-kinase (PI3K) signaling pathway inhibitors was investigated in melanoma cell lines harboring BRAFV600E. Human melanoma A375 and WM115 cells were ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8614
更新日期:2018-07-01 00:00:00
abstract::When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5240
更新日期:2016-12-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2019.10030.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11409
更新日期:2020-04-01 00:00:00
abstract::Sclerosing stromal tumor (SST) of the ovary, which was first described by Chalvardjian and Scully in 1973, is a rare ovarian neoplasm, occurring predominantly in young women. The most common clinical symptom in patients with SST is menstrual irregularities. Microscopically, the tumor is characterized by the presence o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4441
更新日期:2016-06-01 00:00:00
abstract::Vestibular schwannoma (VS) is a benign, slow-growing cranial tumor that originates from the hypertrophy of Schwann cells. The majority of sporadic VS are unilateral, and the mechanisms underlying VS tumorigenesis are not fully understood. The human neurofibromin 2 (NF2) gene encodes the tumor suppressor protein merlin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4685
更新日期:2016-08-01 00:00:00
abstract::Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7074
更新日期:2017-12-01 00:00:00
abstract::Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous report...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6003
更新日期:2017-06-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11888
更新日期:2020-10-01 00:00:00
abstract::The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12077
更新日期:2020-11-01 00:00:00
abstract::AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8854
更新日期:2018-08-01 00:00:00
abstract::Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7184
更新日期:2017-12-01 00:00:00
abstract::The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10505
更新日期:2019-08-01 00:00:00
abstract::Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer. CHD5 expression was evaluated using immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11138
更新日期:2020-01-01 00:00:00
abstract::Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11614
更新日期:2020-07-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. Wnt family member 10A (Wnt10a) is an oncogene associated with the carcinogenesis and progression of renal cell carcinoma, and is strongly expressed in the CRC cell line SW480. However, the role of Wnt10a in CRC has been rarely...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10035
更新日期:2019-04-01 00:00:00
abstract::Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10737
更新日期:2019-10-01 00:00:00
abstract::Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3743
更新日期:2015-12-01 00:00:00
abstract::Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5415
更新日期:2017-01-01 00:00:00
abstract::Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2440
更新日期:2014-11-01 00:00:00
abstract::The present study aimed to identify the level of programmed death-1 (PD-1) expression in infiltrating cluster of differentiation (CD)4+ and CD8+ T cells isolated from lung cancer tissues, and investigated whether the level of PD-1 expression may be directly regulated by lung cancer cells via prostaglandin E2 (PGE2)-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7279
更新日期:2018-01-01 00:00:00
abstract::Small cell carcinoma of the rectum is extremely rare. The present study aimed to improve the recognition of computed tomography (CT) and magnetic resonance imaging (MRI) features observed in patients with small cell carcinoma of the rectum. A total of 4 cases of patients with histologically confirmed small cell carcin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4136
更新日期:2016-03-01 00:00:00
abstract::This study investigated the expression of special AT-rich sequence-binding protein 1 (SATB1) and toll-like receptor 4 (TLR4) protein in breast cancer and its clinical significance. We collected breast cancer tissues from 120 patients and adjacent non-cancerous tissue from 53 patients. SATB1 was expressed in 89 cases o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6571
更新日期:2017-09-01 00:00:00
abstract::Cisplatin-resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin-based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8433
更新日期:2018-06-01 00:00:00
abstract::The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4176
更新日期:2016-03-01 00:00:00
abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10589
更新日期:2019-09-01 00:00:00
abstract::Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1454
更新日期:2013-09-01 00:00:00
abstract::Hepatocyte growth factor (HGF) expression is a poor prognostic factor in various types of cancer. Expression levels of HGF have been reported to be regulated by shorter poly(dA) sequences in the promoter region. In the present study, the poly(dA) mononucleotide tract in various types of human cancer cell lines was exa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2702
更新日期:2015-01-01 00:00:00