Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells.

abstract：:Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...

journal_title：Oncology letters

authors： Tomasello B,Malfa GA,Strazzanti A,Gangi S,Di Giacomo C,Basile F,Renis M

更新日期：2017-01-01 00:00:00

abstract：:The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previou...

journal_title：Oncology letters

authors： Guo H,Zhou LX,Ma H,Liu B,Cheng J,Ma YY,Zhao L

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...

journal_title：Oncology letters

authors： Tang H,Kong Y,Si L,Cui C,Sheng X,Chi Z,Dai J,Yu S,Ma M,Wu X,Yu J,Xu T,Yu H,Yan J,Guo J

更新日期：2018-02-01 00:00:00

abstract：:Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's Hospital. The clinicopa...

journal_title：Oncology letters

authors： Wang H,Chen P,Zhao W,Shi L,Gu X,Xu Q

更新日期：2014-04-01 00:00:00

abstract：:Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...

journal_title：Oncology letters

authors： Xu Y,Wang Z,Bi Y,Duan Z,Yue X

更新日期：2018-08-01 00:00:00

abstract：:Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...

journal_title：Oncology letters

authors： Al-Qasem A,Toulimat M,Tulbah A,Elkum N,Al-Tweigeri T,Aboussekhra A

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of peroxisome proliferator-activated receptor (PPAR)-γ in inflammatory bowel disease (IBD), and to also identify the association between PPAR-γ and the clinical features of patients with IBD. An azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model of ...

journal_title：Oncology letters

authors： Dou X,Xiao J,Jin Z,Zheng P

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of HPV16E6 gene integration on the biological behavior of Eca109 and Eca9706 cells. This was evaluated through positive liposome transfection of HPV16E6 into Eca109 cells and Eca9706 cells. The transfection efficiency was evaluated by calculating the ratio of ...

journal_title：Oncology letters

authors： Kang XD,Zheng Y,Chen WG,Cheng M,Zhang D

更新日期：2018-02-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...

journal_title：Oncology letters

authors： He J,Mu M,Luo Y,Wang H,Ma H,Guo S,Fang Q,Qian Z,Lu H,Song C

更新日期：2019-03-01 00:00:00

abstract：:Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The usual treatment of GC consists of surgery with additional adjuvant chemotherapy. In the present study, the feasibility and safety of adjuvant S-1 plus oxaliplatin (SOX) chemotherapy for patients with GC and the optimal dosage of...

journal_title：Oncology letters

authors： Yang L,Yang Y,Qin Q,Zhou A,Zhao J,Wang J,Shu C,Yuan X,Hu S

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...

journal_title：Oncology letters

authors： Zhang JB,Zhao LR,Cui TX,Chen XW,Yang Q,Zhou YB,Chen ZT,Zhang SX,Sun JG

更新日期：2018-04-01 00:00:00

abstract：:MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell pro...

journal_title：Oncology letters

authors： Hou Y

更新日期：2019-01-01 00:00:00

abstract：:Sarcomatoid carcinomas exhibit features that are common to epithelial and mesenchymal tumors. These carcinomas are rare, particularly in the small intestine. In the current case report, we describe a case of an intestinal sarcomatoid carcinoma in a 70-year-old Chinese female. Sarcomatoid carcinoma was confirmed based ...

journal_title：Oncology letters

authors： Han N,Han QH,Liu YZ,Li ZC,Li J

更新日期：2013-08-01 00:00:00

abstract：:A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...

journal_title：Oncology letters

authors： Kim DD,Yang CS,Chae HD,Kwak SG,Jeon CH

更新日期：2017-07-01 00:00:00

abstract：:Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...

journal_title：Oncology letters

authors： Gao X,Wang M,Zhang Y,Xu Z,Ding J,Tang J

更新日期：2019-09-01 00:00:00

abstract：:Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...

journal_title：Oncology letters

authors： Yang H,Wang R,Zeng F,Zhao J,Peng S,Ma Y,Chen S,Ding S,Zhong L,Guo W,Wang W

更新日期：2020-10-01 00:00:00

abstract：:Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...

journal_title：Oncology letters

authors： Xia Y,Zhang J,Ni X

更新日期：2020-10-01 00:00:00

abstract：:Early mitotic inhibitor-1 (Emi1), as a key cell cycle regulatory gene, induces S phase and mitotic entry by controlling anaphase-promoting complex substrates. Emi1 overexpression may be a prognostic factor for patients with invasive breast cancer. However, its expression and clinical significance in esophageal squamou...

journal_title：Oncology letters

authors： Guan C,Zhang J,Zhang J,Shi H,Ni R

更新日期：2016-07-01 00:00:00

abstract：:The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

journal_title：Oncology letters

authors： Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

更新日期：2017-03-01 00:00:00

abstract：:Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...

journal_title：Oncology letters

authors： Zhang J,Jing X,Niu W,Zhang M,Ge L,Miao C,Tang X

更新日期：2016-07-01 00:00:00

abstract：:Lung cancer causes over 1.6 million mortalities worldwide annually. MicroRNAs (miRs) are involved in various types of cancer-associated processes. The present study investigated the possible mechanism of miR-107 in the development of lung cancer in order to identify novel targets for clinical treatment. The expression...

journal_title：Oncology letters

authors： Cai P,Li J,Chen G,Peng B,Yu L,Zhao B,Yu Y

更新日期：2020-03-01 00:00:00

abstract：:Management of multinodular hepatocellular carcinoma (HCC) in the intermediate Barcelona Clinic Liver Cancer (BCLC)-B stage is controversial. The aim of the present study as to identify the subgroup of patients with BCLC-B HCC who could benefit from liver resection. The present study retrospectively analyzed the outcom...

journal_title：Oncology letters

authors： Matsukuma S,Sakamoto K,Tokuhisa Y,Tokumitsu Y,Matsui H,Kanekiyo S,Tomochika S,Iida M,Suzuki N,Takeda S,Ueno T,Wada H,Kobayashi S,Saeki I,Eguchi H,Sakon M,Sakaida I,Nagano H

更新日期：2018-11-01 00:00:00

abstract：:Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS present...

journal_title：Oncology letters

authors： Nakamura K,Nakayama K,Ishikawa M,Ishikawa N,Katagiri H,Katagiri A,Ishibashi T,Sato E,Iida K,Sultana R,Kyo S

更新日期：2016-11-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...

journal_title：Oncology letters

authors： Delgado-Ramirez Y,Colly V,Gonzalez GV,Leon-Cabrera S

更新日期：2020-07-01 00:00:00

abstract：:Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...

journal_title：Oncology letters

authors： Chen Q,Zhou Z,Shan L,Zeng H,Hua Y,Cai Z

更新日期：2015-07-01 00:00:00

abstract：:For numerous years, the non-cardiovascular role of the renin-angiotensin system (RAS) was underestimated, but recent studies have advanced the understanding of its function in various processes, including carcinogenesis. Numerous evidence comes from preclinical and clinical studies on the use of antihypertensive agent...

journal_title：Oncology letters

authors： Sobczuk P,Szczylik C,Porta C,Czarnecka AM

更新日期：2017-11-01 00:00:00

abstract：:Urothelial carcinoma (UC) is the most common type of cancer of the bladder and upper urinary tract, and is characterized by a high risk of recurrence and progression. Urine fluorescence in situ hybridization (FISH) is a technique that detects genetic aberrations in exfoliated cells in the urine, with specific probes f...

journal_title：Oncology letters

authors： Lin T,Liu Z,Liu L,Yang L,Han P,Zhang P,Wei Q

更新日期：2017-05-01 00:00:00

abstract：:Primary pulmonary leiomyosarcoma (PPL) is an extremely rare malignant tumor. It has been revealed that PPL may originate from the smooth muscle of the pulmonary parenchyma, pulmonary arteries and bronchi. Patients with PPL may be asymptomatic or present with symptoms similar to those observed in other primary lung tum...

journal_title：Oncology letters

authors： Xie X,Chen Y,Ding C,Yu X,Zou L,Xu B,Wang L,Huang X

更新日期：2016-03-01 00:00:00

abstract：:Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....

journal_title：Oncology letters

authors： Li X,Yan ML,Yu Q

更新日期：2017-06-01 00:00:00

abstract：:Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summari...

journal_title：Oncology letters

authors： Höres T,Wendelin K,Schaefer-Eckart K

更新日期：2018-01-01 00:00:00