Abstract:
:The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previously been investigated. The present study examined the plasma levels of suPAR and the expression of the uPAR on bone marrow (BM) cells in 86 patients with leukemia at diagnosis prior to chemotherapy and 26 normal subjects (control group). The plasma suPAR levels were measured using ELISA, whilst uPAR expression was assayed by flow cytometry analysis. In addition, cell surface uPAR expression on K562 and multidrug-resistant K562/ADM cell lines was studied by western blotting. On admission and follow-up, the levels of suPAR in patients with leukemia were significantly increased compared with controls. Systemic levels of suPAR were strongly associated with the numbers of white blood cells. A case was defined as uPAR-positive (uPAR+) if >20% of the gated cells expressed uPAR. In comparison with 26 healthy BM samples that were negative for uPAR expression, 48 (55.8%) of the 86 leukemia patients were uPAR+. uPAR expression on the cell surface of multidrug-resistant K562/ADM cells was increased compared with that on K562 cells. In conclusion, plasma suPAR expression may be a useful marker for subtype classification of patients with leukemia and cell surface uPAR may be associated with resistance to chemotherapy or disease progression.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Guo H,Zhou LX,Ma H,Liu B,Cheng J,Ma YY,Zhao Ldoi
10.3892/ol.2017.6150subject
Has Abstractpub_date
2017-07-01 00:00:00pages
383-389issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-6150journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Hepatocellular carcinoma is a serious public health problem in China. The mortality rate associated with the majority of cancer types has decreased as a result of targeted therapy. However, the mortality rates associated with hepatocellular carcinoma have not improved; therefore, the identification of new molecular ta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12245
更新日期:2020-12-01 00:00:00
abstract::Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6473
更新日期:2017-09-01 00:00:00
abstract::Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in the ubiquitin-proteasome pathway, has been reported to be overexpressed in certain tumor types and to have an important role in the Fanconi anemia pathway. In the present study, the expression of UBE2T and its association with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5237
更新日期:2016-12-01 00:00:00
abstract::Significant antitumor activity of Momordica anti-human immunodeficiency virus protein of 30 kDa (MAP30) purified from Momordica charantia has been the subject of previous research. However, the effective mechanism of MAP30 on malignant glioma cells has not yet been clarified. The aim of the present study was to invest...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8073
更新日期:2018-04-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2012.934.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11421
更新日期:2020-04-01 00:00:00
abstract::It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7651
更新日期:2018-03-01 00:00:00
abstract::Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8027
更新日期:2018-04-01 00:00:00
abstract::Gelatinases are overexpressed in several types of maligancies and tumor stromal cells. Lidamycin is an enediyne antitumor antibiotic, which is composed of an apoprotein (LDP) and an active chromophore (AE). It is known that the heavy-chain complementarity-determining region-3 (CDR3) domain of scFv is important in anti...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1143
更新日期:2013-04-01 00:00:00
abstract::Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The usual treatment of GC consists of surgery with additional adjuvant chemotherapy. In the present study, the feasibility and safety of adjuvant S-1 plus oxaliplatin (SOX) chemotherapy for patients with GC and the optimal dosage of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2821
更新日期:2015-03-01 00:00:00
abstract::The present case report describes the infrequent coexistence of squamous cell transformation and the epidermal growth factor receptor (EGFR) T790M mutation as resistance mechanisms to first line treatment with tyrosine kinase inhibitors. The patient was a 44-year-old female, diagnosed with a primitive advanced lung ad...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6913
更新日期:2017-11-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3874
更新日期:2016-01-01 00:00:00
abstract::The aim of the present study was to determine the impact of obesity on radiation-induced gastrointestinal (GI) and genitourinary (GU) toxicity. The cases of 54 patients with prostate cancer, treated with three-dimensional conformal radiation therapy (RT), were reviewed. For each patient, the body mass index (BMI), dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1658
更新日期:2014-01-01 00:00:00
abstract::The outcomes of matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) remain controversial. The clinical outcome in patients that undergo transplantation following failed IST is typically poorer when compared with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2341
更新日期:2014-10-01 00:00:00
abstract::Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7928
更新日期:2018-04-01 00:00:00
abstract::It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6917
更新日期:2017-11-01 00:00:00
abstract::Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8051
更新日期:2018-04-01 00:00:00
abstract::Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9111
更新日期:2018-09-01 00:00:00
abstract::The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5673
更新日期:2017-03-01 00:00:00
abstract::It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11779
更新日期:2020-09-01 00:00:00
abstract::[-2]pro-prostate-specific antigen (2pPSA), a proform of PSA, is a new marker in patients at risk of prostate cancer. We explored the potential role of 2pPSA in the identification of patients with metastatic progression following radical prostatectomy for prostate cancer. Seventy-six patients with biochemical (PSA) rec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.570
更新日期:2012-04-01 00:00:00
abstract::Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10637
更新日期:2019-09-01 00:00:00
abstract::Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7781
更新日期:2018-03-01 00:00:00
abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7940
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to investigate the anticancer effects of corosolic acid (CA) in the human lung adenocarcinoma A549 cell line. A549 cells were treated with increasing concentrations of CA, prior to assessing cell viability, migration rate, vascular endothelial growth factor receptor 2 (VEGFR2) kinase activity a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10262
更新日期:2019-06-01 00:00:00
abstract::The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected fro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5264
更新日期:2016-12-01 00:00:00
abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1102
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The result...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.527
更新日期:2012-03-01 00:00:00
abstract::Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11643
更新日期:2020-08-01 00:00:00
abstract::The present study aimed to investigate the effects of overexpression of interferon-induced transmembrane protein 5 (IFITM5) and IFITM5 c.-14C>T mutation on osteogenic differentiation, and the proliferation, migration and invasion of SaOS2 cells. SaOS2 cells were transfected with plasmids containing wild type IFITM5 (W...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5426
更新日期:2017-01-01 00:00:00