Abstract:
:Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cycle in the G2/M phase, and reduced the metastasis of human RCC ACHN cells via the upregulation of p21waf/cip1 and E-cadherin and the downregulation of cyclin dependent kinase 1, cyclin B1, N-cadherin, and hypoxia-inducible factor-1α (HIF-1α). Further mechanistic study revealed that bufalin reduced the expression of phosphorylated (phospho)-Akt and phospho-mammalian target of rapamycin (mTOR). Moreover, HIF-1α expression may be regulated through the inhibition of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mTOR signaling pathway. Thus, the present results suggest that bufalin induces cell cycle arrest and suppresses metastasis; this process may be associated with the PI3K/Akt/mTOR signaling pathway. Accordingly, it is suggested that bufalin is a therapeutic agent for RCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xie J,Lin W,Huang L,Xu N,Xu A,Chen B,Watanabe M,Liu C,Huang Pdoi
10.3892/ol.2018.9111subject
Has Abstractpub_date
2018-09-01 00:00:00pages
3867-3873issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-9111journal_volume
16pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Colorectal carcinoma (CRC) is a common tumor of the digestive system with poor prognosis. Studies have shown that aberrant microRNA (miRNA) expression can affect CRC progression by regulating target genes. In the present study, we investigated the functional roles and potential mechanisms of miR-331-3p in CRC. The exp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11029
更新日期:2019-12-01 00:00:00
abstract::Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11539
更新日期:2020-07-01 00:00:00
abstract::The aim of the present study was to investigate the effects of the heat shock protein (HSP)90 inhibitor AUY922 on the proliferation and migratory ability of renal cell carcinoma (RCC) cells. The expression of HSP90 was measured in vitro using western blotting and quantitative polymerase chain reaction in the ACHN and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3299
更新日期:2015-08-01 00:00:00
abstract::Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9358
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to objectively evaluate the benefits of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy for early-stage cervical cancer. Clinical data were prospectively collected from patients with IA-IIB cervical cancer who underwent laparoscopically assisted vaginal radical hyst...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.311
更新日期:2011-07-01 00:00:00
abstract::The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3279
更新日期:2015-08-01 00:00:00
abstract::Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11788
更新日期:2020-09-01 00:00:00
abstract::DNA hypermethylation plays a major role in the regulation of gene expression in differentiation, development and diseases. The DNA mismatch repair system, which includes Mut-S-Homologon-2 (MSH2) protein, is essential to maintain the stability of the genome during repeated duplication. This study aimed to investigate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2482
更新日期:2014-11-01 00:00:00
abstract::Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3665
更新日期:2015-11-01 00:00:00
abstract::In the present study, a low molecular weight polysaccharide, ABP-AW1, isolated from Agaricus blazei Murill was assessed for its potential adjuvant activity. ABP-AW1 is considered to create a 'depot' of antigen at a subcutaneous injection site. ICR mice were immunized with 100 μg ovalbumin (OVA) alone or with 100 μg OV...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1484
更新日期:2013-10-01 00:00:00
abstract::The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The pote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6042
更新日期:2017-06-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. Currently, 5-fluorouracil (5-FU) remains a widely used chemotherapeutic drug in the treatment of CRC; however, 5-FU resistance during treatment has become a common problem. Livin, a member of the inhibitor of apoptosis pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8282
更新日期:2018-05-01 00:00:00
abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1725
更新日期:2014-02-01 00:00:00
abstract::Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10530
更新日期:2019-09-01 00:00:00
abstract::Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung d...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2978
更新日期:2015-05-01 00:00:00
abstract::MicroRNAs (miRs) are a group of short, endogenous, non-protein-coding and single-stranded RNAs that regulate gene expression by binding to the 3'-untranslated region (3'UTR) of mRNAs, which results in their degradation or translational repression. The aim of the present study was to investigate the expression and func...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7126
更新日期:2017-12-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, and its incidence has been on the increase in recent years. However, the molecular mechanism of PTC is unclear and misdiagnosis remains a major issue. Therefore, the present study aimed to investigate this mechanism, and to identify key pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11100
更新日期:2020-01-01 00:00:00
abstract::In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9920
更新日期:2019-03-01 00:00:00
abstract::Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7329
更新日期:2018-01-01 00:00:00
abstract::Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9467
更新日期:2018-11-01 00:00:00
abstract::The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12159
更新日期:2020-12-01 00:00:00
abstract::Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10637
更新日期:2019-09-01 00:00:00
abstract::The safety and immunological responsiveness of a peptide vaccine of ring finger protein 43 and 34-kDa translocase of the outer mitochondrial membrane combined with uracil-tegafur/leucovorin (UFT/LV) was previously demonstrated in metastatic colorectal cancer (CRC) in a phase I clinical trial. To clarify the survival b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7905
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8388
更新日期:2018-06-01 00:00:00
abstract::The present study sought to characterize the role of macrophage inflammatory protein-3α (MIP-3α) in non-small cell lung cancer (NSCLC) patients with early recurrence or metastasis after primary pulmonary resection. Follow-up examinations were conducted for 203 NSCLC patients with primary pulmonary resection for two ye...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2229
更新日期:2014-08-01 00:00:00
abstract::Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2225
更新日期:2014-08-01 00:00:00
abstract::The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.488
更新日期:2012-02-01 00:00:00
abstract::Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Fu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9858
更新日期:2019-02-01 00:00:00
abstract::In our previous study, we demonstrated that type II cGMP-dependent protein kinase (PKG II) was expressed at lower levels in different human cancer cell lines and that exogenous PKG II inhibited epidermal growth factor (EGF)-induced MAPK/ERK signaling. In order to investigate its functions further in this signaling pat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.851
更新日期:2012-11-01 00:00:00