Abstract:
:Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts in tumor microenvironments have emerged as an important target for cancer therapy. Repeated stimulation by infectious or non-infectious agents in the uterine tissues, including inflammation, mechanical forces or hypoxia, stimulate the resident fibroblasts to undergo specific activation and, thus, are significant in tumorigenesis. Furthermore, complex signaling pathways regulate the mechanisms of fibroblastic activation. The current review focuses on the molecular mechanisms of fibroblastic activation and the potential association with uterine leiomyoma pathogenesis, enabling an integrated pathogenic analysis for review of the therapeutic options.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zheng LH,Cai FF,Ge I,Biskup E,Cheng ZPdoi
10.3892/ol.2014.2225subject
Has Abstractpub_date
2014-08-01 00:00:00pages
479-486issue
2eissn
1792-1074issn
1792-1082pii
ol-08-02-0479journal_volume
8pub_type
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