Serum vascular endothelial growth factor-C levels predict lymph node metastasis and prognosis of patients with gallbladder cancer.

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...

journal_title：Oncology letters

authors： Tang H,Kong Y,Si L,Cui C,Sheng X,Chi Z,Dai J,Yu S,Ma M,Wu X,Yu J,Xu T,Yu H,Yan J,Guo J

更新日期：2018-02-01 00:00:00

abstract：:Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Wang P,Zhao JG,Wang ZF,Chen LI

更新日期：2016-05-01 00:00:00

abstract：:Abnormal glucose metabolism is critical in colorectal cancer (CRC) development. Expression of the pyruvate kinase (PK) M2 isoform, rather than the PKM1 isoform, serves important functions in reprogramming the glucose metabolism of cancer cells. Preferential expression of PKM2 is primarily driven by alternative splicin...

journal_title：Oncology letters

authors： Sun Y,Luo M,Chang G,Ren W,Wu K,Li X,Shen J,Zhao X,Hu Y

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...

journal_title：Oncology letters

authors： Zhao X,Zhu D,Lu C,Yan D,Li L,Chen Z

更新日期：2016-02-01 00:00:00

abstract：:Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...

journal_title：Oncology letters

authors： Imai A,Matsunami K,Takagi H,Ichigo S

更新日期：2014-07-01 00:00:00

abstract：:The prognosis following surgical treatment of gastric carcinoma (GC) or gastroesophageal junction (GEJ) adenocarcinoma remains poor. Although adjuvant chemo-radiotherapy with 5-fluorouracil has been shown to be beneficial, a high rate of distant failure has been reported. Thus, the toxicity profile and efficacy of an ...

journal_title：Oncology letters

authors： Shulman K,Haim N,Wollner M,Bernstein Z,Abdah-Bortnyak R,Bar-Sela G

更新日期：2012-05-01 00:00:00

abstract：:Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B-cell primary non-Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7-year period of complete ...

journal_title：Oncology letters

authors： Hu JY,Yu D,Wu YH

更新日期：2018-04-01 00:00:00

abstract：:Patients with non-platinum-sensitive recurrent ovarian cancer have a poor prognosis. Non-pegylated liposomal doxorubicin (Myocet®) is a promising drug that may be able to improve treatment for such patients. In the current study, patients with recurrent ovarian cancer relapsing within 12 months after primary treatment...

journal_title：Oncology letters

authors： Brucker J,Mayer C,Gebauer G,Mallmann P,Belau AK,Schneeweiss A,Sohn C,Eichbaum M

更新日期：2016-08-01 00:00:00

abstract：:In patients with diffuse large B-cell lymphoma (DLBCL) classified as high-intermediate risk or high risk using the International Prognosis Index, the efficacy of high-dose chemotherapy combined with upfront autologous stem cell transplantation (HDT/ASCT) remains controversial in the rituximab era. In the present study...

journal_title：Oncology letters

authors： Nakaya A,Fujita S,Satake A,Nakanishi T,Azuma Y,Tsubokura Y,Hotta M,Yoshimura H,Ishii K,Ito T,Nomura S

更新日期：2017-09-01 00:00:00

abstract：:The management of recurrent diffuse low-grade gliomas (LGGs) is controversial. In the present study, the multidisciplinary management of 35 patients with recurrent LGGs was retrospectively analyzed. Tumor progression or recurrence was defined by clinical, radiological and/or metabolic pejorative evolution. All patient...

journal_title：Oncology letters

authors： Spitaels J,Devriendt D,Sadeghi N,Luce S,De Witte O,Goldman S,Mélot C,Lefranc F

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...

journal_title：Oncology letters

authors： Cheng S,Li Y,Zhang M,Tong T

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to identify the level of programmed death-1 (PD-1) expression in infiltrating cluster of differentiation (CD)4+ and CD8+ T cells isolated from lung cancer tissues, and investigated whether the level of PD-1 expression may be directly regulated by lung cancer cells via prostaglandin E2 (PGE2)-as...

journal_title：Oncology letters

authors： Wang J,Zhang L,Kang D,Yang D,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...

journal_title：Oncology letters

authors： Jin C,Song P,Pang J

更新日期：2019-10-01 00:00:00

abstract：:Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the featur...

journal_title：Oncology letters

authors： Hori T,Yasuda T,Suzuki K,Kanamori M,Kimura T

更新日期：2012-05-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide. The present study investigated the effects of K9(C4H4FN2O2)2Nd(PW11O39)2·25H2O (FNdPW), a chemically synthesized polyoxometalate that contains rare earth elements, on lung cancer growth, and explored the mechanism underlying its actions. The ef...

journal_title：Oncology letters

authors： Xia RY,Zhang RR,Jiang Z,Sun YJ,Liu J,Chen FH

更新日期：2017-03-01 00:00:00

abstract：:Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...

journal_title：Oncology letters

authors： Jin S,Xu C,Wang L,Wei J,Wang S

更新日期：2021-02-01 00:00:00

abstract：:The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probe...

journal_title：Oncology letters

authors： Ke Z,Lai Y,Ma X,Lil S,Huang W

更新日期：2014-02-01 00:00:00

abstract：:A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...

journal_title：Oncology letters

authors： Liu LH,Yang XF

更新日期：2016-06-01 00:00:00

abstract：:It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...

journal_title：Oncology letters

authors： Zou C,Lyu Y,Jiang J,Cao Y,Wang M,Sang C,Zhang R,Li H,Liew CC,Cheng C,Zhao S

更新日期：2020-09-01 00:00:00

abstract：:Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...

journal_title：Oncology letters

authors： Rath-Wolfson L,Bergman M,Ori Y,Goldman A,Ram E,Koren R,Salman H

更新日期：2013-01-01 00:00:00

abstract：:In recent decades, thyroid cancer (TC) has become one of the most common endocrine malignancies. Next-generation sequencing of paired TC and adjacent healthy thyroid tissues demonstrated that polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) may serve as a tumour suppressor gene in thyroid cancer. However, the ...

journal_title：Oncology letters

authors： Zheng C,Quan R,Xia EJ,Bhandari A,Zhang X

更新日期：2019-09-01 00:00:00

abstract：:The detection of epidermal growth factor receptor (EGFR) mutations is necessary for the selection of suitable patients with non-small cell lung cancer (NSCLC) for treatment with EGFR tyrosine kinase inhibitors. Cytology specimens are known to be suitable for EGFR mutation detection, although tissue specimens should be...

journal_title：Oncology letters

authors： Asaka S,Yoshizawa A,Nakata R,Negishi T,Yamamoto H,Shiina T,Shigeto S,Matsuda K,Kobayashi Y,Honda T

更新日期：2018-02-01 00:00:00

abstract：:Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin-bound paclitaxel (nab-PTX) is a...

journal_title：Oncology letters

authors： Kimura K,Tanaka S,Iwamoto M,Fujioka H,Takahashi Y,Sato N,Terasawa R,Tominaga T,Ikari A,Uchiyama K

更新日期：2013-10-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00

abstract：:A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...

journal_title：Oncology letters

authors： Dong Y,Li Y,Liu R,Li Y,Zhang H,Liu H,Chen J

更新日期：2020-03-01 00:00:00

abstract：:Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...

journal_title：Oncology letters

authors： Kochi T,Shimizu M,Ohno T,Baba A,Sumi T,Kubota M,Shirakami Y,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2014-07-01 00:00:00

abstract：:Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment. Chemokines are an important factor affecting the tumor immune microenvironme...

journal_title：Oncology letters

authors： Wu B,Wang J,Wang X,Zhu M,Chen F,Shen Y,Zhong Z

更新日期：2020-11-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT. EMT occurred i...

journal_title：Oncology letters

authors： He X,Qian Y,Cai H,Yang S,Cai J,Wang Z

更新日期：2015-08-01 00:00:00