MicroRNA-335 is downregulated in papillary thyroid cancer and suppresses cancer cell growth, migration and invasion by directly targeting ZEB2.

abstract：:The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...

journal_title：Oncology letters

authors： Zhao Z,Li C,Song Y,Wu Q,Qiao F,Fan H

更新日期：2012-02-01 00:00:00

abstract：:In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...

journal_title：Oncology letters

authors： Deng H,Zhen H,Fu Z,Huang X,Zhou H,Liu L

更新日期：2012-01-01 00:00:00

abstract：:The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitor...

journal_title：Oncology letters

authors： Zhong L,Chen J,Huang X,Li Y,Jiang T

更新日期：2018-08-01 00:00:00

abstract：:The epithelial cell adhesion molecule (EpCAM) is overexpressed in the majority of human epithelial carcinomas, and its overexpression is associated with proliferation and neoplastic transformation. However, the precise molecular mechanism involved in EpCAM-related proliferation and metastasis in hypopharyngeal carcino...

journal_title：Oncology letters

authors： Mu Y,Sa N,Yu L,Lu S,Wang H,Xu W

更新日期：2014-07-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) show great promise as novel cancer biomarkers. Several studies have revealed an association between abnormal miRNA expression and the risk of various cancer types. However, the diagnostic accuracy and reliability of miRNAs remains unclear. The present meta-analysis was performed to summarize th...

journal_title：Oncology letters

authors： Liu B,Liu Y,Luo X,Pan Y,Yang L,Li F,Gao R,Chen W,He J

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...

journal_title：Oncology letters

authors： Yang X,Cai W,Yang Q,Lu Z,Li J,Yu J

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to present the results of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC), and to clarify patient characteristics by investigating patient background factors. A total of 59 patients with EC, who received MPA as fertility-sparing therapy a...

journal_title：Oncology letters

authors： Fujiwara H,Jobo T,Takei Y,Saga Y,Imai M,Arai T,Taneichi A,Machida S,Takahashi Y,Suzuki M

更新日期：2012-05-01 00:00:00

abstract：:In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Sueishi M

更新日期：2014-10-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...

journal_title：Oncology letters

authors： Meng L,Liu B,Ji R,Jiang X,Yan X,Xin Y

更新日期：2019-02-01 00:00:00

abstract：:Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...

journal_title：Oncology letters

authors： Ueno T,Soh J,Hiraki T,Asano H,Ichimura K,Shibamoto K,Gobara H,Kanazawa S,Toyooka S,Miyoshi S

更新日期：2012-02-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in host cell entry. The ...

journal_title：Oncology letters

authors： Yang R,Liang J,Xu GX,Ding LM,Huang HM,Su QZ,Yan J,Li YC

更新日期：2018-05-01 00:00:00

abstract：:Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...

journal_title：Oncology letters

authors： Kim MY

更新日期：2020-04-01 00:00:00

abstract：:The present study designed a novel preoperative chemoradiotherapy (CRT) with sequential oxaliplatin and irinotecan with S-1 for locally advanced rectal cancer (LARC). This phase I study evaluated the maximum tolerated dose and recommended dose (RD) of oxaliplatin following irinotecan with S-1. Patients with clinical s...

journal_title：Oncology letters

authors： Fujikawa H,Toiyama Y,Inoue Y,Omura Y,Ide S,Kitajima T,Yasuda H,Okugawa Y,Okita Y,Yoshiyama S,Hiro J,Kobayashi M,Ohi M,Araki T,Kusunoki M

更新日期：2019-04-01 00:00:00

abstract：:Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...

journal_title：Oncology letters

authors： Liu P,Du R,Yu X

更新日期：2019-08-01 00:00:00

abstract：:Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...

journal_title：Oncology letters

authors： Liu YZ,Wang TT,Zhang YZ

更新日期：2016-02-01 00:00:00

abstract：:Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine-platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 201...

journal_title：Oncology letters

authors： Dano D,Delteil C,Boissier R,Delaporte V,Habert P,Salas S,Duffaud F,Deville JL

更新日期：2019-03-01 00:00:00

abstract：:The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previou...

journal_title：Oncology letters

authors： Guo H,Zhou LX,Ma H,Liu B,Cheng J,Ma YY,Zhao L

更新日期：2017-07-01 00:00:00

abstract：:Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in pos...

journal_title：Oncology letters

authors： Zhang H,Jiang P,Zhang C,Lee S,Wang W,Zou H

更新日期：2018-11-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a ...

journal_title：Oncology letters

authors： Peng Y,Liu Q,Wang Y,Song A,Duan H,Qiu Y,Li Q,Cui HJ

更新日期：2019-08-01 00:00:00

abstract：:Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...

journal_title：Oncology letters

authors： Chaudhary S,Krishna BM,Mishra SK

更新日期：2017-08-01 00:00:00

abstract：:Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...

journal_title：Oncology letters

authors： Liu Y,Liang Y,Li M,Liu D,Tang J,Yang W,Tong D,Jin X

更新日期：2018-10-01 00:00:00

abstract：:The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and prolife...

journal_title：Oncology letters

authors： Han L,Jiang Y,Han D,Tan W

更新日期：2018-10-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies and is the second leading cause of cancer-associated mortality world-wide. In the present study, the prognostic value and antitumor effects of transforming growth factor β1 (TGFβ1) and its receptors in GC were explored. The online Kaplan-Meier plotter database...

journal_title：Oncology letters

authors： Liu F,Wang H,Zhang M

更新日期：2020-09-01 00:00:00

abstract：:Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient receiv...

journal_title：Oncology letters

authors： Cao J,Zhou Y,Zou F,Ma JA,Hu C

更新日期：2017-03-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. G. lucidum has been associated with prostate cancer cells. G...

journal_title：Oncology letters

authors： Qu L,Li S,Zhuo Y,Chen J,Qin X,Guo G

更新日期：2017-12-01 00:00:00

abstract：:Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...

journal_title：Oncology letters

authors： Shi Y,Li X,Chen X,Xu Y,Bo G,Zhou H,Liu Y,Zhou G,Wang Z

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...

journal_title：Oncology letters

authors： Sun W,Li C,Liu M,Liu W,Yang C,Cai LI

更新日期：2016-03-01 00:00:00

abstract：:The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred...

journal_title：Oncology letters

authors： Gao Q,Zhang X,Xiang H,Ren G,Zheng Y

更新日期：2014-01-01 00:00:00