Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.

abstract：:The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

journal_title：Oncology letters

authors： Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

更新日期：2017-03-01 00:00:00

abstract：:Cancer/testis (CT) antigens are promising targets for immunotherapy due to their restricted expression in the germ cells of the testis in healthy tissue and high immunogenicity. The aim of the present study was to determine whether transmembrane protein 31 (TMEM31) is a CT antigen and to investigate the pattern of TME...

journal_title：Oncology letters

authors： Li J,Zou X,Li C,Zhong J,Chen Y,Zhang X,Qi F,Li M,Cai Z,Tang A

更新日期：2017-04-01 00:00:00

abstract：:Mosquito coils, which are commonly used as residential insecticides in Asia, contain different concentrations of octachlorodipropyl ether (S-2) as a synergist or an active ingredient. As bis(chloromethyl) ether (BCME) is an extremely potent lung carcinogen that can be produced by the thermolytic degradation of S-2, co...

journal_title：Oncology letters

authors： Zhang J,Qi HW,Sun YP,Xie HK,Zhou CC

更新日期：2015-04-01 00:00:00

abstract：:The histological boundary between benign and malignant vascular tumors is not clear. Thus, the discrepancies between clinical judgement and pathological diagnosis often lead to a difficult clinical decision, and may result in misdiagnosis. In order to develop more effective treatment methods, the clinical and patholog...

journal_title：Oncology letters

authors： Li F,Ma L,Zhang L,Zheng L,Lv X,Fu J

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...

journal_title：Oncology letters

authors： Wei ZT,Yu XW,He JX,Liu Y,Zhang SL

更新日期：2017-09-01 00:00:00

abstract：:Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average survival time of 4-12 months following diagnosis. The present study reports the case of a 57-year-old male patient who presented to the Bağcılar Training and Research Hospital (Istanbul, Turkey) due to swelling in the neck and di...

journal_title：Oncology letters

authors： Altinay S,Taş B,Ozen A,Süt PA

更新日期：2014-06-01 00:00:00

abstract：:Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...

journal_title：Oncology letters

authors： Aziz MY,Omar AR,Subramani T,Yeap SK,Ho WY,Ismail NH,Ahmad S,Alitheen NB

更新日期：2014-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been reported to participate in multiple biological processes, including tumorigenesis. In the current study, the function of a novel lncRNA LINC00887 was investigated in lung carcinoma. For this purpose, LINC00887 expression was assessed by reverse-transcription quantitative PCR. C...

journal_title：Oncology letters

authors： Xu LB,Bo BX,Xiong J,Ren YJ,Han D,Wei SH,Ren XP

更新日期：2021-02-01 00:00:00

abstract：:Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...

journal_title：Oncology letters

authors： Song T,Yang H,Ho JC,Tang SC,Sze SC,Lao L,Wang Y,Zhang KY

更新日期：2015-06-01 00:00:00

abstract：:The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...

journal_title：Oncology letters

authors： Wang C,Chen L,Huang Y,Li K,Jinye A,Fan T,Zhao R,Xia X,Shen B,Du J,Liu Y

更新日期：2019-02-01 00:00:00

abstract：:Ilex kudingcha C.J. Tseng (Kudingcha) is a traditional Chinese drink consumed in East Asia. The present study evaluated the in vitro anticancer effects of Kudingcha in MCF-7 human breast adenocarcinoma cells using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay. At a concentration of 200 μg/...

journal_title：Oncology letters

authors： Zhao X,Wang Q,Qian Y,Song JL

更新日期：2013-05-01 00:00:00

abstract：:The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...

journal_title：Oncology letters

authors： Wang S,Liu X,Huang J,Zhang Y,Sang C,Li T,Yuan J

更新日期：2018-09-01 00:00:00

abstract：:Maternal embryonic leucine zipper kinase (MELK) is an important regulator in tumorigenesis of human breast cancer, and if silenced leads to programmed cell death in specific breast cancer cell lines, including MDA-MB-231 cells. In the present study, RNA interference, proliferation assay and semi-quantification of cell...

journal_title：Oncology letters

authors： Li G,Yang M,Zuo L,Wang MX

更新日期：2018-06-01 00:00:00

abstract：:Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...

journal_title：Oncology letters

authors： Liu X,Zhang S,Gang Q,Shen S,Zhang J,Lun Y,Xu D,Duan Z,Xin S

更新日期：2018-04-01 00:00:00

abstract：:Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...

journal_title：Oncology letters

authors： Xu X,Wu J,Ren G,Hu Q

更新日期：2019-09-01 00:00:00

abstract：:Focal adhesion kinase (FAK) has long been considered to be a key regulator of growth factor receptor- and integrin-mediated signals, with pivotal roles in tumor cells through its kinase activity and scaffolding function. Increased FAK expression and activity has been observed in tumors of various origins and is often ...

journal_title：Oncology letters

authors： Li M,Hou F,Zhao J,Zhang T,Li D,Wu W,Liu X,Xu L

更新日期：2018-03-01 00:00:00

abstract：:The present study aimed to reveal the key long non-coding RNAs (lncRNAs) and the potential molecular mechanisms of XAV939 treatment in non-small cell lung cancer (NSCLC). The NSCLC cell line, NCI-H1299, was cultured with 10 µM XAV939 for 12 h, and NCI-H1299 cells without XAV939 treatment were used as controls. Followi...

journal_title：Oncology letters

authors： Yu H,Han Z,Xu Z,An C,Xu L,Xin H

更新日期：2019-06-01 00:00:00

abstract：:Activating transcription factor 2 (ATF2) is a member of the cAMP response element binding protein family that heterodimerizes and activates other transcription factors involved in stress and DNA damage responses, growth, differentiation and apoptosis. ATF2 has been investigated as a potential carcinogenic biomarker in...

journal_title：Oncology letters

authors： You Z,Zhou Y,Guo Y,Chen W,Chen S,Wang X

更新日期：2016-01-01 00:00:00

abstract：:The clinicopathological value and exploration of the potential molecular mechanism of microRNA-183-5p (miR-183-5p) have been investigated in various cancers; however, to the best of the author's knowledge, no similar research has been reported for bladder cancer. In the present study, it was revealed that the expressi...

journal_title：Oncology letters

authors： Gao JM,Huang LZ,Huang ZG,He RQ

更新日期：2018-04-01 00:00:00

abstract：:Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...

journal_title：Oncology letters

authors： Jia Z,Zhang Y,Xu Q,Guo W,Guo A

更新日期：2018-05-01 00:00:00

abstract：:Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...

journal_title：Oncology letters

authors： Kadochi Y,Mori S,Fujiwara-Tani R,Luo Y,Nishiguchi Y,Kishi S,Fujii K,Ohmori H,Kuniyasu H

更新日期：2017-07-01 00:00:00

abstract：:For individualized bevacizumab-based therapy, non-invasive biomarkers are necessary. This study assessed the predictive value of plasma vascular endothelial growth factor (VEGF)-A, soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 levels as biomarkers for clinical response and survival in advanced colorectal cancer (CRC) ...

journal_title：Oncology letters

authors： Aoyagi Y,Iinuma H,Horiuchi A,Shimada R,Watanabe T

更新日期：2010-03-01 00:00:00

abstract：:The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration ...

journal_title：Oncology letters

authors： Huang T,Jin X,He L,Zhang M,Wu J,Wang Y,Fang J

更新日期：2013-11-01 00:00:00

abstract：:Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...

journal_title：Oncology letters

authors： Wang CJ,Chao CR,Liu HM,Zhu YY,Adell G,Jarlsfelt I,Zhang H,Sun XF

更新日期：2019-11-01 00:00:00

abstract：:The multidrug resistance of glioma impedes chemo-radiotherapy and leads to adverse outcomes. In the present study, the doxorubicin (DOX)-resistant glioma SHG44/DOX cell line was established to investigate the effects and mechanisms of Salvia miltiorrhiza ligustrazine (SML), a traditional Chinese medicine, on the rever...

journal_title：Oncology letters

authors： Wang F,Huang N,Yang Q,Liu J,Chen J

更新日期：2017-10-01 00:00:00

abstract：:Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...

journal_title：Oncology letters

authors： Yuan YJ,Zhou P,Xia F,Zhang XB,He SS,Guo DY,Xing YH,Zhao HW

更新日期：2020-10-01 00:00:00

abstract：:The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...

journal_title：Oncology letters

authors： Yuan F,Zhang S,Xie W,Yang S,Lin T,Chen X

更新日期：2020-06-01 00:00:00

abstract：:The present study aimed to investigate the feasibility of using ecto-mesenchymal stem cell (EMSC)-derived dendritic cells (DCs) for glioma immunotherapy following infection by a recombinant adenovirus containing the melanoma-associated antigen D4a (MAGE-D4a) gene. The ex vivo cultured EMSCs were infected by the adenov...

journal_title：Oncology letters

authors： Hu S,Li B,Shen X,Zhang R,Gao D,Guo Q,Jin Y,Fei Z

更新日期：2016-04-01 00:00:00

abstract：:The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...

journal_title：Oncology letters

authors： Zhou Y,Zou H,Wu E,Huang L,Yin R,Mei Y,Zhu X

更新日期：2018-08-01 00:00:00

abstract：:Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...

journal_title：Oncology letters

authors： Guo Q,He Y,Sun L,Kong C,Cheng Y,Zhang G

更新日期：2019-04-01 00:00:00