Abstract:
:Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was performed to evaluate the expression level of circRNAs based on a microarray dataset obtained from the Gene Expression Omnibus database. Univariate and multivariate Cox regression analyses were performed to evaluate the association between survival and expression of circRNAs in each OC cohort. An expression-based risk score model was constructed to extrapolate the prognostic efficacy of this signature. In the GSE9891 dataset, the 278 OC patients were randomly divided into training and validating groups. A six-circRNA signature was significantly associated with overall survival in the training and validating datasets. The risk score model was further validated in GSE63885 and GSE26193 datasets. The six-circRNA signature was also significantly associated with patient progression-free survival and disease-free survival. Further investigation revealed that the signature had higher area under the curve values than the existing clinical and other molecular signatures in predicting survival. In conclusion, the present study revealed that the six-circRNA signature may serve as a potential prognostic biomarker of OC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Guo Q,He Y,Sun L,Kong C,Cheng Y,Zhang Gdoi
10.3892/ol.2019.10021subject
Has Abstractpub_date
2019-04-01 00:00:00pages
3677-3686issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-10021journal_volume
17pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study designed a novel preoperative chemoradiotherapy (CRT) with sequential oxaliplatin and irinotecan with S-1 for locally advanced rectal cancer (LARC). This phase I study evaluated the maximum tolerated dose and recommended dose (RD) of oxaliplatin following irinotecan with S-1. Patients with clinical s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10028
更新日期:2019-04-01 00:00:00
abstract::Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5415
更新日期:2017-01-01 00:00:00
abstract::Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6718
更新日期:2017-10-01 00:00:00
abstract::This study investigated the effects of hyperoside on apoptosis of human thyroid squamous cell carcinoma cells (SW579) and measured changes in the expression of known apoptosis regulatory players Fas/FasL and survivin. SW579 cells were treated with increasing concentrations of hyperoside. The cell proliferation inhibit...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6453
更新日期:2017-08-01 00:00:00
abstract::Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4628
更新日期:2016-07-01 00:00:00
abstract::Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6605
更新日期:2017-09-01 00:00:00
abstract::Although there is evidence that galectin-9 is a critical factor in health and disease, the upstream regulatory microRNA (miRNA or miR) of the protein remains poorly defined. miR-455-5p is characterized as a tumor-associated miRNA in cancer research. However, the actual role of miR-455-5p with respect to inhibiting or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5608
更新日期:2017-03-01 00:00:00
abstract::Cancer stem cells (CSCs) are proposed to be closely correlated with the development and progression of tumors, as well as with chemo- and radioresistance. Targeting CSCs may therefore be a promising potential strategy for the treatment of cancer. Currently, natural products have received great interest due to their th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4431
更新日期:2016-06-01 00:00:00
abstract::The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5710
更新日期:2017-04-01 00:00:00
abstract::Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5702
更新日期:2017-04-01 00:00:00
abstract::The endogenous lipid metabolism network is associated with the occurrence and progression of malignancies. Endocannabinoids and ceramides have demonstrated their anti-proliferative and pro-apoptotic properties in a series of cancer studies. The aim of the present study was to evaluate the expression patterns of endoca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10399
更新日期:2019-08-01 00:00:00
abstract::The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2880
更新日期:2015-03-01 00:00:00
abstract::The purpose of the present study was to evaluate the recent trend of diagnosing appendiceal diseases through the analysis of appendectomy materials, stressing the importance of their pathological examination. A clinicopathological assessment of patients undergoing an appendectomy was conducted, based on the pathologic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8134
更新日期:2018-05-01 00:00:00
abstract::Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9195
更新日期:2018-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a serious threat to human health. Chemotherapy drugs such as cisplatin are widely used in cancer treatment, but can cause severe side effects. Hydroxyl safflower yellow A (HSYA) is a water-soluble chalcone glycoside substance extracted from safflowers (Carthamus tinctorius L.) that ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9946
更新日期:2019-03-01 00:00:00
abstract::The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11534
更新日期:2020-07-01 00:00:00
abstract::Multiple myeloma is defined as a malignant proliferation of a single clone of plasma cells resulting in monoclonal immunoglobulin production. Due to the number of plasma cell morphological variants, difficulty is often faced during morphological diagnosis. The current study describes the case of a 49-year-old woman pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4197
更新日期:2016-03-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Ga...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2232
更新日期:2014-08-01 00:00:00
abstract::The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7580
更新日期:2018-02-01 00:00:00
abstract::Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 4...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3767
更新日期:2015-12-01 00:00:00
abstract::Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11071
更新日期:2020-01-01 00:00:00
abstract::The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5511
更新日期:2017-02-01 00:00:00
abstract::Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12275
更新日期:2021-01-01 00:00:00
abstract::For numerous years, the non-cardiovascular role of the renin-angiotensin system (RAS) was underestimated, but recent studies have advanced the understanding of its function in various processes, including carcinogenesis. Numerous evidence comes from preclinical and clinical studies on the use of antihypertensive agent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6826
更新日期:2017-11-01 00:00:00
abstract::The aim of the present study is to investigate if rapamycin is a radiosensitizer of nasopharyngeal carcinoma (NPC), and to identify which pathways are involved in radiation sensitization. In vitro, using untreated cells as the control, NPC cells were treated with rapamycin, ionizing radiation (IR) or both. Differences...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6208
更新日期:2017-07-01 00:00:00
abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2820
更新日期:2015-03-01 00:00:00
abstract::Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. In the present study, TFC was found to potent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3795
更新日期:2015-12-01 00:00:00
abstract::Aberrant promoter methylation of tumor relevant genes frequently occurs in early steps of carcinogenesis and during tumor progression. Epigenetic alterations could be used as potential biomarkers for early detection and for prediction of prognosis and therapy response in lung cancer. The present study quantitatively a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4927
更新日期:2016-10-01 00:00:00