Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma.

abstract：:Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, ...

journal_title：Oncology letters

authors： Toshiyama R,Konno M,Eguchi H,Asai A,Noda T,Koseki J,Asukai K,Ohashi T,Matsushita K,Iwagami Y,Yamada D,Asaoka T,Wada H,Kawamoto K,Gotoh K,Kudo T,Satoh T,Doki Y,Mori M,Ishii H

更新日期：2018-05-01 00:00:00

abstract：:The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biops...

journal_title：Oncology letters

authors： Glover M,Soni S,Ren Q,Maclennan GT,Fu P,Gupta S

更新日期：2017-10-01 00:00:00

abstract：:Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

journal_title：Oncology letters

authors： Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...

journal_title：Oncology letters

authors： Palkina N,Komina A,Aksenenko M,Moshev A,Savchenko A,Ruksha T

更新日期：2018-06-01 00:00:00

abstract：:Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB)...

journal_title：Oncology letters

authors： Tian X,Wang Y,Liu Y,Yin J,Chen D,Ke X,Ma W

更新日期：2018-10-01 00:00:00

abstract：:To determine the radiosensitizing effect of apatinib on esophageal cancer cells, and to preliminarily investigate the underlying mechanism, KYSE-150 cells were treated with apatinib, x-ray or apatinib combined with x-ray, and compared with a blank control. It was observed that apatinib significantly inhibited vascular...

journal_title：Oncology letters

authors： Hu L,Sun F,Sun Z,Ni X,Wang J,Wang J,Zhou M,Feng Y,Kong Z,Hua Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：:The causes of lung cancer in never-smokers remain unclear. The potential contribution of human papillomavirus (HPV) to the carcinogenesis of non-small cell lung cancer (NSCLC) has been reported. In 2008, a prospective registry of never-smokers with NSCLC was established at the Kinki-Chuo Chest Medical Center, Sakai, O...

journal_title：Oncology letters

authors： Isa SI,Kurahara Y,Yamamoto S,Tamiya A,Omachi N,Asami K,Okishio K,Utsumi T,Ito N,Yoon HE,Matsumura A,Atagi S,Kawaguchi T

更新日期：2015-02-01 00:00:00

abstract：:The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...

journal_title：Oncology letters

authors： Liu J,Wang Y,Tang Y,Luo J,Long Y,Tan S

更新日期：2020-12-01 00:00:00

abstract：:The current report presents the case of a 41-year-old male exhibiting a giant cell tumor of the tendon sheath (GCT-TS) arising from the patellar tendon sheath. Plain radiography and magnetic resonance imaging revealed a well-localized mass that wrapped around the patellar tendon, and extended from the subcutis into th...

journal_title：Oncology letters

authors： Akahane T,Mori N,Yoshida K

更新日期：2014-12-01 00:00:00

abstract：:Interleukin-8 (IL-8), an important inflammatory factor, is induced by Helicobacter pylori infection and is clearly associated with gastric cancer. IL-8 levels have been revealed to correlate significantly with the adhesion, migration and invasion of gastric cancer cells. However, whether IL-8 influences cell prolifera...

journal_title：Oncology letters

authors： Shi J,Wei PK

更新日期：2014-12-01 00:00:00

abstract：:Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...

journal_title：Oncology letters

authors： Inoue Y,Matsumoto H,Yamada S,Kawai K,Suemizu H,Gika M,Takanami I,Iwazaki M,Nakamura M

更新日期：2010-09-01 00:00:00

abstract：:Distant metastases from colorectal cancer (CRC) most frequently spread to the liver and lungs. CRC metastasis to the kidney is extremely rare and may be generally associated with an unfavorable prognosis. Thus, patients with metastatic CRC and kidney metastasis are a diagnostic and therapeutic challenge. The present s...

journal_title：Oncology letters

authors： Dulskas A,Bagurskas P,Sinkevicius Z,Samalavicius NE

更新日期：2015-08-01 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...

journal_title：Oncology letters

authors： Fei X,Zhang J,Zhao Y,Sun M,Zhao H,Li S

更新日期：2018-06-01 00:00:00

abstract：:It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the hu...

journal_title：Oncology letters

authors： Cheng L,Kong B,Zhao Y,Jiang J

更新日期：2018-03-01 00:00:00

abstract：:ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...

journal_title：Oncology letters

authors： Liu X,Li G,Ai L,Ye Q,Yu T,Yang B

更新日期：2019-08-01 00:00:00

abstract：:Patients with non-platinum-sensitive recurrent ovarian cancer have a poor prognosis. Non-pegylated liposomal doxorubicin (Myocet®) is a promising drug that may be able to improve treatment for such patients. In the current study, patients with recurrent ovarian cancer relapsing within 12 months after primary treatment...

journal_title：Oncology letters

authors： Brucker J,Mayer C,Gebauer G,Mallmann P,Belau AK,Schneeweiss A,Sohn C,Eichbaum M

更新日期：2016-08-01 00:00:00

abstract：:The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The pote...

journal_title：Oncology letters

authors： Kim W,Kang J,Lee S,Youn B

更新日期：2017-06-01 00:00:00

abstract：:Lung cancer is the most frequent cause of cancer-associated mortality among men and women globally. The skeleton is one of the most common metastatic sites. The majority of patients exhibiting bone metastases are treated using systemic therapy or symptom-based palliative approaches without surgery. The present study a...

journal_title：Oncology letters

authors： Zhao T,Gao Z,Wu W,He W,Yang YI

更新日期：2016-03-01 00:00:00

abstract：:Downregulation of microRNA-34a (miR-34a) has frequently been observed in esophageal squamous cell carcinoma (ESCC). However, the underlying role and molecular mechanism of miR-34a in ESCC remains largely unknown. In the current study, it was demonstrated that miR-34a was downregulated and forkhead box M1 (FOXM1), a ta...

journal_title：Oncology letters

authors： Zhou H,Yang L,Xu X,Lu M,Guo R,Li D,Huang Q,Liu Y,Deng G,Xu Y

更新日期：2019-01-01 00:00:00

abstract：:The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA fro...

journal_title：Oncology letters

authors： Liu Y,Wang R,Zhang L,Li J,Lou K,Shi B

更新日期：2017-06-01 00:00:00

abstract：:The present study reports a case of low-grade fibromyxoid sarcoma that occurred in a 62-year-old woman 9 years subsequent to whole breast irradiation for a carcinoma of the left breast, and 18 years following chemotherapy and radiotherapy (RT) for non-Hodgkin's lymphoma (NHL; diagnosed at the age of 43). The patient w...

journal_title：Oncology letters

authors： Shibata S,Shiraishi K,Yamashita H,Kobayashi R,Nakagawa K

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...

journal_title：Oncology letters

authors： Zhou G,Liu X,Xiong B,Sun Y

更新日期：2017-10-01 00:00:00

abstract：:Hypoxic microenvironments and angiogenesis have been a focus of tumor research in previous years. The aim of the the present study was to create a hypoxic model and observe the effect of hypoxia on the expression of hypoxia inducible factor-1α (HIF-1α), insulin-like growth factor I (IGF-1) and vascular endothelial gro...

journal_title：Oncology letters

authors： Liu Q,Xu Z,Mao S,Chen W,Zeng R,Zhou S,Liu J

更新日期：2015-03-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...

journal_title：Oncology letters

authors： Yang J,Ma JP,Xiao S,Zhang XH,Xu JB,Chen CQ,Cai SR,He YL

更新日期：2018-05-01 00:00:00

abstract：:AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...

journal_title：Oncology letters

authors： Zhou R,Wu J,Tang X,Wei X,Ju C,Zhang F,Sun J,Shuai D,Zhang Z,Liu Q,Lv XB

更新日期：2018-08-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous report...

journal_title：Oncology letters

authors： Fujii T,Sakai E,Takahashi H,Yamada E,Ohkubo H,Higurashi T,Nakajima A

更新日期：2017-06-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in host cell entry. The ...

journal_title：Oncology letters

authors： Yang R,Liang J,Xu GX,Ding LM,Huang HM,Su QZ,Yan J,Li YC

更新日期：2018-05-01 00:00:00

abstract：:The putative oncogenic role of ATP/GTP binding protein like 2 (AGBL2) in catalyzing α-tubulin detyrosination has recently been characterized in cancer. However, the status of AGBL2 expression in ovarian cancer and its potential clinical and prognostic significance remain unclear. In the present study, immunohistochemi...

journal_title：Oncology letters

authors： He WP,Wang LL

更新日期：2019-11-01 00:00:00

abstract：:Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment. Chemokines are an important factor affecting the tumor immune microenvironme...

journal_title：Oncology letters

authors： Wu B,Wang J,Wang X,Zhu M,Chen F,Shen Y,Zhong Z

更新日期：2020-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...

journal_title：Oncology letters

authors： Wang Z,Fu H,Li W

更新日期：2018-09-01 00:00:00