Improved antitumor effect of ionizing radiation in combination with rapamycin for treating nasopharyngeal carcinoma.

abstract：:Activation of brown adipose tissue (BAT) is an effective strategy for treating obesity. Hepatocellular carcinoma (HCC) is a life-threatening hepatic malignancy with a high mortality rate. Considering that obesity is a risk factor for HCC, the aim of the present study was to investigate the association between HCC and ...

journal_title：Oncology letters

authors： Liu D,Li Y,Shang Y,Wang W,Chen SZ

更新日期：2019-03-01 00:00:00

abstract：:Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 4...

journal_title：Oncology letters

authors： Wu S,Xu R,Zhao H,Zhu X,Zhang L,Zhao X

更新日期：2015-12-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...

journal_title：Oncology letters

authors： Jin C,Song P,Pang J

更新日期：2019-10-01 00:00:00

abstract：:Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...

journal_title：Oncology letters

authors： Zhao SF,Wang SG,Zhao ZY,Li WL

更新日期：2019-11-01 00:00:00

abstract：:Choristoma is a mass of tissue that is histologically normal for the organ or part of the body from which it originates, but is located at an abnormal site. Choristoma of the nervous system involves the occurrence of residual dysplastic tissues outside the nervous system and exhibits a low incidence. Thus far, there h...

journal_title：Oncology letters

authors： Chang PF,Qu LM,Li M,Qi B

更新日期：2017-08-01 00:00:00

abstract：:Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. Th...

journal_title：Oncology letters

authors： Han L,Liu F,Li R,Li Z,Chen X,Zhou Z,Zhang X,Hu T,Zhang Y,Young K,Sun S,Wen J,Zhang M

更新日期：2014-10-01 00:00:00

abstract：:Congenital leukemia is rare disease with an incidence of one to five cases per million births. Transient abnormal myelopoiesis (TAM), also called transient myeloproliferative disorder, is a pre-leukemia disorder that may occur in Down syndrome (DS) or non-DS infants. TAM may enter spontaneous remission; however, conti...

journal_title：Oncology letters

authors： Salvatori G,Foligno S,Sirleto P,Genovese S,Russo S,Coletti V,Dotta A,Luciani M

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...

journal_title：Oncology letters

authors： Li R,Wu G,Wang R

更新日期：2018-02-01 00:00:00

abstract：:Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...

journal_title：Oncology letters

authors： Lee SR,Shin JW,Kim HO,Son BH,Yoo CH,Shin JH

更新日期：2013-02-01 00:00:00

abstract：:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

journal_title：Oncology letters

authors： Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

更新日期：2012-10-01 00:00:00

abstract：:The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...

journal_title：Oncology letters

authors： Nojiri K,Sugimoto K,Shiraki K,Kusagawa S,Tanaka J,Beppu T,Yamamoto N,Takei Y,Hashimoto A,Shimizu A,Omori S,Tameda M,Takase K

更新日期：2010-05-01 00:00:00

abstract：:The Notch signaling pathway has been shown to be involved in the progression of chronic myeloid leukemia (CML). The aim of this study was to investigate the effects of exogenous Notch2 overexpression on cell proliferation and possible mechanisms in the human CML cell line K562. When exogenous intracellular fragment of...

journal_title：Oncology letters

authors： Yang Z,Yang C,Zhang S,Li Y,Chen J

更新日期：2013-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of serum containing a combination of yi-qi-yang-yin-tang (YQYYT) and daunorubicin (DNR) on multidrug resistance in KG1a leukemia stem cells (LSCs). The effects of YQYYT and DNR on proliferation, cell cycle progression and the expression of phosphatase and tensin homol...

journal_title：Oncology letters

authors： Shi ZX,Li HY,Yang XD,Gao H,Li DG,Yang WH,Yao F,Yan LX

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...

journal_title：Oncology letters

authors： Su L,Liu M

更新日期：2018-07-01 00:00:00

abstract：:Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...

journal_title：Oncology letters

authors： Zhao ZQ,Yu ZY,Li J,Ouyang XN

更新日期：2016-07-01 00:00:00

abstract：:Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...

journal_title：Oncology letters

authors： Wang J,Du Q,Li C

更新日期：2017-12-01 00:00:00

abstract：:S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. In the present study, the role of S100A11, and its possible underlying mechanisms in cell proliferation, apoptosis and cell cycle distribution in human pancreatic cancer were explored. I...

journal_title：Oncology letters

authors： Xiao M,Li T,Ji Y,Jiang F,Ni W,Zhu J,Bao B,Lu C,Ni R

更新日期：2018-01-01 00:00:00

abstract：:Thyroid carcinoma is the most prevalent endocrine neoplasm globally. In the majority of thyroid carcinoma cases, a positive prognosis is predicted following administration of the appropriate treatment. A wide range of genetic alterations present in thyroid carcinoma exert their oncogenic actions partially through the ...

journal_title：Oncology letters

authors： Jiang L,Chu H,Zheng H

更新日期：2016-04-01 00:00:00

abstract：:Esophageal cancer staging is important for the treatment of esophageal cancer. Endoscopic ultrasonography (EUS) is a common diagnostic tool for esophageal cancer prior to surgery. However, EUS is unable to accurately discriminate the N-staging of lymph nodes. In order to distinguish an optimized standard for malignant...

journal_title：Oncology letters

authors： Zhang Y,He S,Dou L,Liu Y,Ke Y,Yu X,Wang Z,Wang G

更新日期：2019-01-01 00:00:00

abstract：:The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer...

journal_title：Oncology letters

authors： Zheng X,Hu H,Li S

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...

journal_title：Oncology letters

authors： Meng L,Liu B,Ji R,Jiang X,Yan X,Xin Y

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 L...

journal_title：Oncology letters

authors： Zhou C,Li J,Li J,Wan Y,Li T,Ma P,Wang Y,Sang H

更新日期：2016-09-01 00:00:00

abstract：:Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...

journal_title：Oncology letters

authors： Aziz MY,Omar AR,Subramani T,Yeap SK,Ho WY,Ismail NH,Ahmad S,Alitheen NB

更新日期：2014-05-01 00:00:00

abstract：:Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Yin Y,Hu X,Cui Y

更新日期：2018-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to s...

journal_title：Oncology letters

authors： Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:RNA interference (RNAi) is a powerful technology for suppressing gene function. In most studies, small interfering RNAs (siRNAs) consist of one short hairpin RNA (shRNA) and, therefore, are often unable to achieve loss-of-function of their target genes. In the current study, an RNAi vector containing three shRNAs unde...

journal_title：Oncology letters

authors： Weng Y,Shi Y,Xia X,Zhou W,Wang H,Wang C

更新日期：2017-03-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) show great promise as novel cancer biomarkers. Several studies have revealed an association between abnormal miRNA expression and the risk of various cancer types. However, the diagnostic accuracy and reliability of miRNAs remains unclear. The present meta-analysis was performed to summarize th...

journal_title：Oncology letters

authors： Liu B,Liu Y,Luo X,Pan Y,Yang L,Li F,Gao R,Chen W,He J

更新日期：2018-11-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00