Reversal of doxorubicin-resistance by Salvia miltiorrhiza ligustrazine in the SHG44/doxorubicin glioma drug-resistant cell line.

abstract：:Nervous system polycomb 1 (NSPc1) is a member of the polycomb group (PcG) family of proteins and has been demonstrated to maintain the differentiation and pluripotency of stem cells. Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the control of pluripotency and differentiation in embryonic and...

journal_title：Oncology letters

authors： Liang Z,Wang Y,Li H,Sun Y,Gong Y

更新日期：2019-06-01 00:00:00

abstract：:Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...

journal_title：Oncology letters

authors： Wu S,Zhang W,Shen D,Lu J,Zhao L

更新日期：2019-12-01 00:00:00

abstract：:Arteriosclerosis poses a significant risk to human health and involves the thickening and hardening of the walls of arteries. Accumulated evidence demonstrates that aberrant proliferation of vascular smooth muscle cells (VSMCs) accounts for the onset and progression of arteriosclerosis. Suppression of their proliferat...

journal_title：Oncology letters

authors： Han D,Zhang X,Zhang J,Guo X,Zheng Y,Sui S,Zheng J

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...

journal_title：Oncology letters

authors： Li SY,Ye JY,Meng FY,Li CF,Yang MO

更新日期：2015-07-01 00:00:00

abstract：:The surgical treatment of patients with advanced lung cancer remains controversial. The current study aimed to identify the factors affecting the prognosis of patients with stage IV non-small cell lung cancer (NSCLC) and to clarify the surgery guidelines. A total of 27,725 patients diagnosed with stage IV NSCLC were s...

journal_title：Oncology letters

authors： Liao Y,Fan X,Wang X

更新日期：2019-07-01 00:00:00

abstract：:As a rare hypopharyngeal diverticulum, Killian-Jamieson diverticulum (KJD) is usually incidentally detected, small, asymptomatic and likely to be misdiagnosed as a thyroid nodule. In order to avoid unnecessary treatments resulting from misdiagnosis, principles to distinguish between esophageal diverticula and thyroid ...

journal_title：Oncology letters

authors： Cao L,Ge J,Zhao D,Lei S

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...

journal_title：Oncology letters

authors： Ikeda S,Naruse K,Nagata C,Kuramochi M,Onuki T,Inagaki M,Suzuki K

更新日期：2015-05-01 00:00:00

abstract：:The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...

journal_title：Oncology letters

authors： Cao F,Li A,Li J,Fang YU,Li F

更新日期：2015-10-01 00:00:00

abstract：:Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...

journal_title：Oncology letters

authors： Qin J,Li Q,Zeng Z,Wu P,Jiang Y,Luo T,Ji X,Zhang Q,Hao Y,Chen L

更新日期：2018-06-01 00:00:00

abstract：:Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...

journal_title：Oncology letters

authors： Tas F,Ciftci R,Kilic L,Karabulut S

更新日期：2013-11-01 00:00:00

abstract：:A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endotheli...

journal_title：Oncology letters

authors： Donato G,Conforti F,Camastra C,Ammendola M,Donato A,Renzulli A

更新日期：2014-07-01 00:00:00

abstract：:Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts i...

journal_title：Oncology letters

authors： Zheng LH,Cai FF,Ge I,Biskup E,Cheng ZP

更新日期：2014-08-01 00:00:00

abstract：:Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...

journal_title：Oncology letters

authors： Lee SS,Min H,Ha JY,Kim BH,Choi MS,Kim S

更新日期：2019-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal ca...

journal_title：Oncology letters

authors： Guo Q,Zhao Y,Chen J,Hu J,Wang S,Zhang D,Sun Y

更新日期：2014-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression level of microRNA-182 (miRNA-182) in human osteosarcoma (OS) MG-63 cells and OS tissues, and to elucidate the effect of miRNA-182 on the biological activity of tumors. In the present study, the expression of miRNA-182 in human OS MG-63 cells, OS tissues and n...

journal_title：Oncology letters

authors： Bian DL,Wang XM,Huang K,Zhai QX,Yu GB,Wu CH

更新日期：2016-05-01 00:00:00

abstract：:Cardiac toxicity has been the major concern when using doxorubicin (DOX) in cancer therapy. Thrombopoietin (TPO) protects cardiac cells from DOX-induced cell damage; however, its molecular mechanism remains exclusive. The anti-autophagic and anti-apoptotic effects of TPO upon DOX treatment were studied in the cardiac ...

journal_title：Oncology letters

authors： Wang H,Wang H,Liang EY,Zhou LX,Dong ZL,Liang P,Weng QF,Yang M

更新日期：2018-01-01 00:00:00

abstract：:The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...

journal_title：Oncology letters

authors： Parikh JG,Kulkarni A,Johns C

更新日期：2014-02-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate, particularly in Southern China. Apogossypolone (ApoG2) is a novel derivative of gossypol with antitumor activity and less toxicity. The human NPC CNE-2 cell line was studied in the in vitro model; whilst 4 week-old male nude mice (BALB/c-nu) were ...

journal_title：Oncology letters

authors： Zheng R,Chen K,Zhang Y,Huang J,Shi F,Wu G,Wang S

更新日期：2017-07-01 00:00:00

abstract：:In our previous study, we demonstrated that type II cGMP-dependent protein kinase (PKG II) was expressed at lower levels in different human cancer cell lines and that exogenous PKG II inhibited epidermal growth factor (EGF)-induced MAPK/ERK signaling. In order to investigate its functions further in this signaling pat...

journal_title：Oncology letters

authors： Tao Y,Gu YJ,Cao ZH,Bian XJ,Lan T,Sang JR,Jiang L,Wang Y,Qian H,Chen YC

更新日期：2012-11-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

journal_title：Oncology letters

authors： Dai S,Xu C,Tian Y,Cheng W,Li B

更新日期：2014-10-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...

journal_title：Oncology letters

authors： Li BS,Huang JY,Guan J,Chen LH

更新日期：2018-07-01 00:00:00

abstract：:The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...

journal_title：Oncology letters

authors： Ogose A,Hotta T,Shibata M,Kawashima H,Endo N

更新日期：2010-01-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 ...

journal_title：Oncology letters

authors： Li M,Zhang XL,Deng F,Qian LT,Meng SP,Shan WL,Wang BL

更新日期：2016-11-01 00:00:00

abstract：:The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...

journal_title：Oncology letters

authors： Murakami M,Ichimura T,Kasai M,Matsuda M,Kawamura N,Fukuda T,Sumi T

更新日期：2018-06-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD1...

journal_title：Oncology letters

authors： Lu Q,Lv G,Kim A,Ha JM,Kim S

更新日期：2013-01-01 00:00:00

abstract：:To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reac...

journal_title：Oncology letters

authors： Xia XM,Jin WY,Shi RZ,Zhang YF,Chen J

更新日期：2010-11-01 00:00:00

abstract：:Persistent infection with Helicobacter pylori may contribute to the carcinogenesis of gastric cancer through modulating local prostaglandin E2 (PGE2) levels. Cyclooxygenase-2 (COX-2) and 15-hydroxy prostaglandin dehydrogenase (15-PGDH) are two key enzymes that regulate PGE2 synthesis and inactivation, respectively. Th...

journal_title：Oncology letters

authors： Zhao J,Wen S,Wang X,Zhang Z

更新日期：2017-11-01 00:00:00