Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression.

abstract：:The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

journal_title：Oncology letters

authors： Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

更新日期：2016-12-01 00:00:00

abstract：:Esophageal cancer is one of the most prevalent forms of cancer and has a particularly high mortality rate due to early metastasis; however, the underlying mechanisms of its formation and progression remain unclear. The present study performed immunohistochemical analysis and observed that the expression of activating ...

journal_title：Oncology letters

authors： Li J,Yang Z,Chen Z,Bao Y,Zhang H,Fang X,Yang W

更新日期：2016-09-01 00:00:00

abstract：:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...

journal_title：Oncology letters

authors： Wan S,Zhao H

更新日期：2020-11-01 00:00:00

abstract：:Studies investigating the effects of microRNA (miR)-155 on the behavior of tumor cells have concentrated primarily on proliferation and apoptosis. The aim of the present study was to investigate the effect of miR-155 inhibitor on the metastatic and invasive ability of gastric carcinoma cells and whether this effect is...

journal_title：Oncology letters

authors： Wei H,Li Y,Ning Q,Suo ZM

更新日期：2018-10-01 00:00:00

abstract：:Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...

journal_title：Oncology letters

authors： Ning D,Jin M,Xv T,Sun J,Li M

更新日期：2018-09-01 00:00:00

abstract：:Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...

journal_title：Oncology letters

authors： Jiang B,Shi W,Li P,Wu Y,Li Y,Bao C

更新日期：2021-01-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00

abstract：:Deoxypodophyllotoxin (DPPT) is extracted and separated from citrus-related plants, including Podophyllum (P.) peltatum, P. pleianthum, P. emodi (also called P. hexandrum) and Diphylleia grayi. DPPT has significant antitumor and antiviral activity. However, due to its strong toxicity and side effects, its use is limite...

journal_title：Oncology letters

authors： Hu S,Zhou Q,Wu WR,Duan YX,Gao ZY,Li YW,Lu Q

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines...

journal_title：Oncology letters

authors： Indrová M,Rossowska J,Pajtasz-Piasecka E,Mikyšková R,Richter J,Rosina J,Sedlacek R,Fišerová A

更新日期：2018-03-01 00:00:00

abstract：:Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...

journal_title：Oncology letters

authors： Xiao M,Yang Z,Tang X,Mu L,Cao X,Wang X

更新日期：2017-08-01 00:00:00

abstract：:Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...

journal_title：Oncology letters

authors： Lee SR,Shin JW,Kim HO,Son BH,Yoo CH,Shin JH

更新日期：2013-02-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell line GLAG-66 and GLAG-66 ...

journal_title：Oncology letters

authors： Zhang H,Yang L,Liu Z,Liu C,Teng X,Zhang L,Yin B,Liu Z

更新日期：2017-09-01 00:00:00

abstract：:Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Altho...

journal_title：Oncology letters

authors： Bascones-Martínez A,Cok S,Bascones-Ilundáin C,Arias-Herrera S,Gomez-Font R,Bascones-Ilundáin J

更新日期：2012-02-01 00:00:00

abstract：:In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...

journal_title：Oncology letters

authors： Kanamori M,Suzuki K,Yasuda T,Hori T

更新日期：2012-06-01 00:00:00

abstract：:In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...

journal_title：Oncology letters

authors： Wang H,Yang R,Zhong L,Zhu XY,Ma PP,Yang XQ,Jiang KL,Liu BZ

更新日期：2017-04-01 00:00:00

abstract：:Skeletal muscle is rich in lymphatic vessels, with an abundant blood supply, and it is an infrequent site of cancer metastasis. Previous studies have demonstrated that enhanced secretion of MyoD may occur when skeletal muscle is injured or becomes cancerous. It was hypothesized that MyoD may act as an endogenous cytok...

journal_title：Oncology letters

authors： Cai C,Qin X,Wu Z,Shen Q,Yang W,Zhang S,Duan J,Liang F,Liu C

更新日期：2016-06-01 00:00:00

abstract：:The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...

journal_title：Oncology letters

authors： Lu J,Tan H,Li B,Chen S,Xu L,Zou Y

更新日期：2020-01-01 00:00:00

abstract：:Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...

journal_title：Oncology letters

authors： Li XM,Luo XG,He JF,Wang N,Zhou H,Yang PL,Zhang TC

更新日期：2018-03-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a common type of rheumatoid disease, which has recently been demonstrated to be associated with the expression of matrix metalloproteinase (MMP)-2. The aim of the present study was to investigate whether MMP-2 interference reduced the osteogenic differentiation of fibroblasts and to expl...

journal_title：Oncology letters

authors： Yuan B,Wu Z

更新日期：2018-03-01 00:00:00

abstract：:The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...

journal_title：Oncology letters

authors： Zhou Y,Zou H,Wu E,Huang L,Yin R,Mei Y,Zhu X

更新日期：2018-08-01 00:00:00

abstract：:Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...

journal_title：Oncology letters

authors： Liu H,Li WZ,Wang XY,Pei YG,Long XY,Chen CY,Hu YB

更新日期：2015-02-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...

journal_title：Oncology letters

authors： Yuan J,Yuan B,Zeng L,Liu B,Chen Y,Meng X,Sun R,Lv X,Wang W,Yang S

更新日期：2020-08-01 00:00:00

abstract：:Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...

journal_title：Oncology letters

authors： Tan KT,Chen PW,Li S,Ke TM,Lin SH,Yang CC

更新日期：2019-08-01 00:00:00

abstract：:Numerous studies concerning hepatic arterial infusion chemotherapy (HAIC) have been conducted by adopting regimens containing 5-fluorouracil (FU), with a favourable efficacy compared with conventional transcatheter arterial chemoembolisation (TACE) treatment; however, the detailed mechanism of HAIC remains unclear. Th...

journal_title：Oncology letters

authors： Gao J,Zhen R,Liao H,Zhuang W,Guo W

更新日期：2018-05-01 00:00:00

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive ...

journal_title：Oncology letters

authors： Sun G,Xing W,Xing R,Cong L,Tong S,Yu S

更新日期：2018-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a highly heterogeneous disease that remains untreatable. MicroRNAs (miRNAs or miRs) play important roles in the pathogenesis of leukemia. miR-21 is highly expressed in multiple types of human cancer and displays oncogenic activities; however, the clinical significance of miR-21 in AML r...

journal_title：Oncology letters

authors： Zhang L,Yu L,Liu Y,Wang S,Hou Z,Zhou J

更新日期：2021-02-01 00:00:00

abstract：:microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...

journal_title：Oncology letters

authors： Nian W,Ao X,Wu Y,Huang Y,Shao J,Wang Y,Chen Z,Chen F,Wang D

更新日期：2013-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) was one of the first cancer types systematically studied at a genomic and transcriptomic level due to its high incidence and aggressivity; however, the detailed mechanism remains unclear, even though it is known that numerous cytokines are involved in the occurrence and development of GBM...

journal_title：Oncology letters

authors： He K,Shi L,Jiang T,Li Q,Chen Y,Meng C

更新日期：2016-10-01 00:00:00