Abstract:
:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at Huangshi Central Hospital were enrolled as the control group (CG). The serum MEG3 expression of patients in the two groups was detected by RT-qPCR, and the ability of MEG3 to aid in the diagnosis of cervical cancer, lymph node metastasis and FIGO staging, as well as to predict mortality was evaluated by ROC curve. In addition, the patients in the OG were divided into high- and low-expression groups according to the median value of MEG3. Kaplan Meier was employed to analyze the survival status, and Cox regression to analyze the independent prognostic factors of cervical cancer patients. The results of the present study revealed that the serum MEG3 expression in the OG was significantly lower than that of the CG (P<0.05). The area under the curve (AUC) of MEG3 in diagnosing cervical cancer was 0.844, the AUC in predicting mortality was 0.858, while that in diagnosing lymph node transfer was 0.707, and that in diagnosing FIGO staging was 0.791. The 5-year survival rate of the high-expression group was higher than that of the low-expression group (P=0.020). Multivariate analysis indicated that MEG3 (HR, 0.173; 95 CI%, 0.028-0.919), lymph node metastasis (HR, 2.259; 95 CI%, 1.004-5.025) and FIGO staging (HR, 0.008; 95 CI%, 1.453-6.248) were independent prognostic factors for cervical cancer patients. Collectively, lncRNA MEG3 may be a diagnostic marker and prognostic indicator for cervical cancer, and has a certain diagnostic value for lymph node metastasis and FIGO staging. Lymph node metastasis, FIGO stage III and IV, and low MEG3 levels were revealed to be independent prognostic factors for cervical cancer patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wan S,Zhao Hdoi
10.3892/ol.2020.12044subject
Has Abstractpub_date
2020-11-01 00:00:00pages
183issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-12044journal_volume
20pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3782
更新日期:2015-12-01 00:00:00
abstract::Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1464
更新日期:2013-09-01 00:00:00
abstract::The present study investigated the potential anticancer activity of the bark of Mangifera zeylanica, an endemic plant in Sri Lanka that has been traditionally used for cancer therapy. Cytotoxic and apoptotic effects were investigated in vitro using sulphorodamine assay, acridine orange and ethidium bromide staining, c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4087
更新日期:2016-02-01 00:00:00
abstract::The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1348
更新日期:2013-07-01 00:00:00
abstract::The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2535
更新日期:2014-12-01 00:00:00
abstract::The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Ga...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2232
更新日期:2014-08-01 00:00:00
abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2820
更新日期:2015-03-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10589
更新日期:2019-09-01 00:00:00
abstract::Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6605
更新日期:2017-09-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11170
更新日期:2020-01-01 00:00:00
abstract::Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6293
更新日期:2017-08-01 00:00:00
abstract::The present study evaluated the association between programmed cell death ligand-1 (PD-L1) expression and long-term oncologic outcomes in colorectal cancer (CRC). PD-L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9264
更新日期:2018-10-01 00:00:00
abstract::MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8557
更新日期:2018-06-01 00:00:00
abstract::Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8762
更新日期:2018-07-01 00:00:00
abstract::Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the mai...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4443
更新日期:2016-06-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically ubiquitylated by male specific lethal 2 (MSL2), which causes upregulatio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10833
更新日期:2019-11-01 00:00:00
abstract::The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3579
更新日期:2015-10-01 00:00:00
abstract::Solanine is an alkaloid and is the main extract of the traditional Chinese herb, Solanum nigrum Linn. It has been reported that Solanine has anti-inflammatory and antitumor properties. The present study aimed to investigate the antitumor effect of Solanine in Jurkat cells and demonstrate the molecular mechanism of ant...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8229
更新日期:2018-05-01 00:00:00
abstract::Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it unsuitable for operative surgery, and resistant to chemotherapy and radiation therapy. Isochorismatase domain-containing protein 1 (ISOC1) has putative isochorismatase act...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10082
更新日期:2019-05-01 00:00:00
abstract::Breast cancer is the second leading cause of cancer-associated mortality in females in the USA. Hsa-miR-599 was demonstrated to function as a tumour suppressor during cancer progression. However, the function and mechanism of the hsa-miR-599 in human breast cancer remain elusive. Thus, the aim of the present study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6651
更新日期:2017-09-01 00:00:00
abstract::The expression of macrophage inhibitory cytokine-1 (MIC-1) of early gastric cancer treated using endoscopic mucosal resection (EMR) and its correlation with prognosis were investigated. One hundred and forty-seven patients with early gastric cancer (less than 20 mm in diameter) were recruited and assigned into an obse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6376
更新日期:2017-08-01 00:00:00
abstract::Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.239
更新日期:2011-03-01 00:00:00
abstract::Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8357
更新日期:2018-05-01 00:00:00
abstract::Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves an important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression of RACK1 in gastric cancer (GC), and its association with the occurrence and development of GC. In ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6741
更新日期:2017-10-01 00:00:00
abstract::In the present study, we analyzed the supra-additive effect of oxaliplatin in combination with gemcitabine on terminal colorectal cancer and its influence on high-mobility group box 1 (HMGB1) expression. A total of 86 patients with terminal colorectal cancer were enrolled in this study. Patients received oxaliplatin i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5053
更新日期:2016-11-01 00:00:00
abstract::Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4605
更新日期:2016-07-01 00:00:00
abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5785
更新日期:2017-04-01 00:00:00
abstract::Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in the ubiquitin-proteasome pathway, has been reported to be overexpressed in certain tumor types and to have an important role in the Fanconi anemia pathway. In the present study, the expression of UBE2T and its association with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5237
更新日期:2016-12-01 00:00:00
abstract::The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5710
更新日期:2017-04-01 00:00:00
abstract::Carbon dioxide (CO2) laser ablation in combination with photodynamic therapy (PDT) has previously been successfully used to treat superficial basal cell carcinoma (BCC). However, the efficacy of this treatment modality is limited in the treatment of deeper lesions and the more aggressive subtypes of BCC. In order to i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1504
更新日期:2013-10-01 00:00:00