Abstract:
:Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, possibly through the generation of reactive oxygen species (ROS). Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages. Notably, hepcidin regulates iron homeostasis in the body by regulating the iron transporter ferroportin. In the present study, it was assumed that high hepcidin expression and low ferroportin expression result in malignancy. Therefore, it was examined whether hepcidin and ferroportin expression levels were correlated with the prognosis of pancreatic cancer in patients. Results revealed that high hepcidin expression levels and low ferroportin expression levels in pancreatic cancer tissue were significantly associated with poor prognosis in the analyses of overall survival (P=0.0140 and 0.0478, respectively). Additionally, there was no significant difference in disease-free survival in the hepcidin- and ferroportin-staining groups. Hepcidin expression correlated with the pathological stage and vascular invasion (P=0.0493 and 0.0400, respectively), and ferroportin expression was correlated with age (P=0.0372). Multivariate analysis of overall survival in the hepcidin-staining group revealed that pathological N factor (pN), adjuvant chemotherapy, and hepcidin expression were independent prognostic factors (P=0.0450, 0.0002, and 0.0049, respectively). Similarly, multivariate analysis of overall survival in the ferroportin-staining group revealed that vascular invasion, and ferroportin expression were independent prognostic factors (P=0.0028, P<0.0001, and P=0.0056, respectively). Thus, hepcidin and ferroportin expressions might be novel prognostic indicators for pancreatic cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Toshiyama R,Konno M,Eguchi H,Asai A,Noda T,Koseki J,Asukai K,Ohashi T,Matsushita K,Iwagami Y,Yamada D,Asaoka T,Wada H,Kawamoto K,Gotoh K,Kudo T,Satoh T,Doki Y,Mori M,Ishii Hdoi
10.3892/ol.2018.8357subject
Has Abstractpub_date
2018-05-01 00:00:00pages
8125-8133issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-8357journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investig...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9019
更新日期:2018-09-01 00:00:00
abstract::A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1447
更新日期:2013-09-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::Although previous studies have demonstrated that Glut-1 is the predominant glucose transporter, is significantly overexpressed in various types of tumor and is correlated with poor prognosis, the potential function and clinical value of Glut-1 expression in osteosarcoma remains largely unclear. In particular, the pros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6437
更新日期:2017-08-01 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation and has been associated with numerous high-risk cancers. Previously, our group and others identified LSD1 as an upregulated gene in ovarian cancer, and reported that the upregulation of LSD1 was associated...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8511
更新日期:2018-06-01 00:00:00
abstract::Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8595
更新日期:2018-06-01 00:00:00
abstract::The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. However, little is known about another of its major constituents, triterpene. This study investigated the anticancer mechanism of a triterpene...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.275
更新日期:2011-05-01 00:00:00
abstract::Expression of the transcription factor hypoxiainducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia, particularly in relation to tumour angiogenesis. Expression of the HIF-1α subunit is responsive to changes in oxygen levels. Overexpression of HIF-1α has been reported to be associated with a po...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1185
更新日期:2013-04-01 00:00:00
abstract::Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8095
更新日期:2018-05-01 00:00:00
abstract::Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6605
更新日期:2017-09-01 00:00:00
abstract::The development of upper tract urothelial carcinoma (UTUC) has been associated with the ingestion of aristolochic acid (AA) in Chinese herbs. The tumors are more malignant and patients have a worse prognosis in China compared with that in Western countries. Recently, whole-genome and exome sequencing of AA-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12212
更新日期:2020-12-01 00:00:00
abstract::Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10759
更新日期:2019-10-01 00:00:00
abstract::Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10530
更新日期:2019-09-01 00:00:00
abstract::Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000137
更新日期:2010-09-01 00:00:00
abstract::Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1853
更新日期:2014-04-01 00:00:00
abstract::The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA fro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6038
更新日期:2017-06-01 00:00:00
abstract::Plant secondary metabolites including alkaloids, demonstrate a complex diversity in their molecular scaffolds and exhibit tremendous pharmacological potential as anti-cancerous therapeutics. The present study aimed to evaluate the anticancer activity of a natural alkaloid, mecambridine, against human oral squamous cel...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7321
更新日期:2018-01-01 00:00:00
abstract::Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B-cell primary non-Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7-year period of complete ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7895
更新日期:2018-04-01 00:00:00
abstract::Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8207
更新日期:2018-05-01 00:00:00
abstract::The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.249
更新日期:2011-03-01 00:00:00
abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2738
更新日期:2015-02-01 00:00:00
abstract::The aim of the present study was to identify a specific biological marker for the diagnosis of colorectal adenomas through the analysis of variations in serum protein profiling in colorectal adenoma patients. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between September 2011 and M...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1304
更新日期:2013-06-01 00:00:00
abstract::In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.641
更新日期:2012-06-01 00:00:00
abstract::As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7432
更新日期:2018-01-01 00:00:00
abstract::Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10060
更新日期:2019-04-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer worldwide. However, operative diagnostic and prognostic systems for ESCC remain to be established. To improve assessment of the prognosis for patients with ESCC, the present study developed an online consensus survival tool for ESCC, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10440
更新日期:2019-08-01 00:00:00
abstract::Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7781
更新日期:2018-03-01 00:00:00
abstract::Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.767
更新日期:2012-09-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a process by which cancer cells acquire mesenchymal properties, such as induction of vimentin, while epithelial-associated genes like E-cadherin are lost. This enables cells to be more metastatic. Factors that are able to induce EMT include growth factors such as transforming...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1635
更新日期:2013-12-01 00:00:00
abstract::Gelatinases are overexpressed in several types of maligancies and tumor stromal cells. Lidamycin is an enediyne antitumor antibiotic, which is composed of an apoprotein (LDP) and an active chromophore (AE). It is known that the heavy-chain complementarity-determining region-3 (CDR3) domain of scFv is important in anti...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1143
更新日期:2013-04-01 00:00:00