Abstract:
:Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non-small cell lung cancer (NSCLC), and to explore the roles of miR-154 in the carcinogenesis and progression of this cancer. Reverse transcription-polymerase chain reaction (RT-qPCR) was performed to detect miR-154 expression in NSCLC tissues and cell lines. In addition, cell proliferation assay, migration and invasion assays were adopted to investigate the functional roles of miR-154 in NSCLC. Bioinformatics analysis, luciferase reporter assay, RT-qPCR and western blot analysis were used to explore the potential targets of miR-154 in NSCLC. According to the results, miR-154 was significantly downregulated in NSCLC tissues and cell lines. Restoration of miR-154 expression inhibited proliferation, migration and invasion of NSCLC cells. In addition, B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI-1) was identified as a direct target gene of miR-154 in NSCLC. In conclusion, miR-154 may function as a tumor suppressor in NSCLC, partly by regulating BMI-1, and the modulation of miR-154 expression represents a potential strategy for the treatment of NSCLC patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Liu S,Yang Y,Chen L,Liu D,Dong Hdoi
10.3892/ol.2018.8595subject
Has Abstractpub_date
2018-06-01 00:00:00pages
10098-10104issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-8595journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2133
更新日期:2014-07-01 00:00:00
abstract::Bone metastasis resulting from breast cancer in pregnancy is rare. In the literature there are few reports regarding osteolytic lesions in pregnancy and no data on the treatment of such femoral fractures. The present study reports a case of a 29-week primigravida presenting with severe lumbosciatica in the left side, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3900
更新日期:2016-01-01 00:00:00
abstract::Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1968
更新日期:2014-06-01 00:00:00
abstract::Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5932
更新日期:2017-05-01 00:00:00
abstract::Urothelial carcinoma (UC) is the most common type of cancer of the bladder and upper urinary tract, and is characterized by a high risk of recurrence and progression. Urine fluorescence in situ hybridization (FISH) is a technique that detects genetic aberrations in exfoliated cells in the urine, with specific probes f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5926
更新日期:2017-05-01 00:00:00
abstract::Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types of cancer worldwide, with exosomes implicated...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7257
更新日期:2017-12-01 00:00:00
abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5572
更新日期:2017-03-01 00:00:00
abstract::The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1886
更新日期:2014-04-01 00:00:00
abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8902
更新日期:2018-08-01 00:00:00
abstract::The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.249
更新日期:2011-03-01 00:00:00
abstract::Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6399
更新日期:2017-08-01 00:00:00
abstract::Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study com...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6874
更新日期:2017-11-01 00:00:00
abstract::Aberrant promoter methylation of tumor relevant genes frequently occurs in early steps of carcinogenesis and during tumor progression. Epigenetic alterations could be used as potential biomarkers for early detection and for prediction of prognosis and therapy response in lung cancer. The present study quantitatively a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4927
更新日期:2016-10-01 00:00:00
abstract::The correlation between expression and prognosis of thyroid transcription factor-1 (TTF-1) and CD44v6 in undifferentiated lung carcinoma was investigated. There were 116 cases with large cell undifferentiated carcinoma in group A, 120 cases with small cell undifferentiated carcinoma in group B and 80 normal individual...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10689
更新日期:2019-10-01 00:00:00
abstract::Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in orde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5761
更新日期:2017-04-01 00:00:00
abstract::Skeletal muscle is rich in lymphatic vessels, with an abundant blood supply, and it is an infrequent site of cancer metastasis. Previous studies have demonstrated that enhanced secretion of MyoD may occur when skeletal muscle is injured or becomes cancerous. It was hypothesized that MyoD may act as an endogenous cytok...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4448
更新日期:2016-06-01 00:00:00
abstract::The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2971
更新日期:2015-04-01 00:00:00
abstract::V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9059
更新日期:2018-09-01 00:00:00
abstract::Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and exp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5830
更新日期:2017-05-01 00:00:00
abstract::Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9448
更新日期:2018-11-01 00:00:00
abstract::Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6605
更新日期:2017-09-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous report...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6003
更新日期:2017-06-01 00:00:00
abstract::Prognosis and treatment differences between initial and second primary chondrosarcoma (pCS) remain unknown. In the present study, patients with chondrosarcoma diagnosed between January 2004 and December 2015 were identified using the Surveillance Epidemiology and End Results database. Kaplan-Meier curves and log-rank ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10329
更新日期:2019-07-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from Garcinia hanburyi, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5284
更新日期:2016-12-01 00:00:00
abstract::Individuals >65 years old account for a large proportion of cancer patients, and usually have poor prognoses due to relative weaker physiological function and lower drug tolerance. To characterize the efficacy and safety of dendritic cell (DC)-activated cytokine-induced killer cell (CIK)-mediated treatment, and develo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5337
更新日期:2016-12-01 00:00:00
abstract::Cytokine therapy is commonly used for tumor immunotherapy. Although early studies focused directly on the tumor, current investigations are more attentive of the tumor microenvironment. Various immune cells and related cytokines in the tumor microenvironment play an important role in the occurrence and development of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5329
更新日期:2016-12-01 00:00:00
abstract::Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2665
更新日期:2015-01-01 00:00:00
abstract::Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11914
更新日期:2020-10-01 00:00:00
abstract::Elevated expression of the retinoic acid-metabolizing enzyme cytochrome P450 26A1 (CYP26A1) has been demonstrated to have an oncogenic function in carcinogenesis. In order to address the oncogenic capacity of CYP26A1 in vivo, transgenic mice that ubiquitously overexpressed CYP26A1 driven by the cytomegalovirus promote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8599
更新日期:2018-06-01 00:00:00