TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.

abstract：:The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...

journal_title：Oncology letters

authors： Tanaka K,Oshikawa G,Akiyama H,Ishida S,Nagao T,Yamamoto M,Miura O

更新日期：2017-07-01 00:00:00

abstract：:Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability of anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In the present study, using human GCA conjugated with ...

journal_title：Oncology letters

authors： Wu M,Zhai S,Gao J,Wei D,Xue J,Zhou Y,Li N,Hu L

更新日期：2019-03-01 00:00:00

abstract：:Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell line GLAG-66 and GLAG-66 ...

journal_title：Oncology letters

authors： Zhang H,Yang L,Liu Z,Liu C,Teng X,Zhang L,Yin B,Liu Z

更新日期：2017-09-01 00:00:00

abstract：:The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...

journal_title：Oncology letters

authors： Onishi K,Miyake M,Hori S,Onishi S,Iida K,Morizawa Y,Tatsumi Y,Nakai Y,Tanaka N,Fujimoto K

更新日期：2020-03-01 00:00:00

abstract：:Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...

journal_title：Oncology letters

authors： Morimoto S,Futani H,Tsuchiyama K,Fukunaga S,Tsukamoto Y,Yoshiya S

更新日期：2014-06-01 00:00:00

abstract：:Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...

journal_title：Oncology letters

authors： Rath-Wolfson L,Bergman M,Ori Y,Goldman A,Ram E,Koren R,Salman H

更新日期：2013-01-01 00:00:00

abstract：:Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...

journal_title：Oncology letters

authors： Mendoza-Almanza G,Ortíz-Sánchez E,Rocha-Zavaleta L,Rivas-Santiago C,Esparza-Ibarra E,Olmos J

更新日期：2019-10-01 00:00:00

abstract：:The upregulation of EPH receptor B4 (EPHB4) results in a survival advantage for tumor cells via the inhibition of the casapse-8-mediated apoptotic pathway, which begins from the cell membrane. The present study investigated the expression patterns of EPHB4, ephrin B2 (EFNB2) and caspase-8 in patients with esophageal s...

journal_title：Oncology letters

authors： Ni Q,Chen P,Zhu B,Li J,Xie D,Ma X

更新日期：2020-01-01 00:00:00

abstract：:Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study com...

journal_title：Oncology letters

authors： Arnold KM,Pohlig RT,Sims-Mourtada J

更新日期：2017-11-01 00:00:00

abstract：:Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...

journal_title：Oncology letters

authors： Liu H,Li Y,Li J,Liu Y,Cui B

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to investigate the safety and efficacy of long intestinal tube placement under fluoroscopic guidance for the treatment of malignant bowel obstruction (MBO). The cases of 74 patients with MBO who underwent long intestinal tube placement under fluoroscopic guidance during the period betw...

journal_title：Oncology letters

authors： Lai H,Wu K,Liu Y,Zeng Z,Zhang B

更新日期：2019-06-01 00:00:00

abstract：:Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...

journal_title：Oncology letters

authors： Wang L,Xu ML,Wang C,Dong QQ,Miao Z,Chen XY,Wang N,He HP,Zhang TC,Luo XG

更新日期：2020-05-01 00:00:00

abstract：:The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...

journal_title：Oncology letters

authors： Yu J,Zhang H,Sun S,Sun S,Li L

更新日期：2019-02-01 00:00:00

abstract：:Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic r...

journal_title：Oncology letters

authors： Litwin M,Szczepańska-Buda A,Piotrowska A,Dzięgiel P,Witkiewicz W

更新日期：2017-05-01 00:00:00

abstract：:Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as a global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the role of SATB1 in gastric cancer, especially in regulating the malignant phenotypes, ...

journal_title：Oncology letters

authors： Sun F,Lu X,Li H,Peng Z,Wu K,Wang G,Tong Q

更新日期：2012-07-01 00:00:00

abstract：:5,7-dihydroxy-3',4',6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidate...

journal_title：Oncology letters

authors： Li YY,Wu H,Dong YG,Lin BO,Xu G,Ma YB

更新日期：2015-10-01 00:00:00

abstract：:Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...

journal_title：Oncology letters

authors： Wang J,Hua L,Guo M,Yang L,Liu X,Li Y,Shang X,Luo J

更新日期：2017-06-01 00:00:00

abstract：:Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent ...

journal_title：Oncology letters

authors： Han SH,Chung JH,Kim J,Kim KS,Han YS

更新日期：2017-05-01 00:00:00

abstract：:Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...

journal_title：Oncology letters

authors： Zou Y,Liang J,Li D,Fang J,Wang L,Wang J,Zhang J,Guo Q,Yan X,Tang H

更新日期：2020-07-01 00:00:00

abstract：:The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...

journal_title：Oncology letters

authors： Lu CZ,Cao SS,Wang W,Liu J,Fu N,Lu F

更新日期：2016-04-01 00:00:00

abstract：:The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected fro...

journal_title：Oncology letters

authors： Chang H,Ma M,Ma R,Zhang C,Zeng W,Xing LQ

更新日期：2016-12-01 00:00:00

abstract：:A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...

journal_title：Oncology letters

authors： Nickelsen MN,VON Holstein S,Hansen AB,Prause JU,Heegaard S

更新日期：2015-08-01 00:00:00

abstract：:Cancer stem cell (CSC) properties have been recently proposed to explain tumor carcinogenesis and multidrug resistance in several human cancers, including non-small cell lung cancer (NSCLC). The present study examined the protein expression of three CSC-associated markers, namely ATP binding cassette subfamily B membe...

journal_title：Oncology letters

authors： Zou F,Seike M,Noro R,Kunugi S,Kubota K,Gemma A

更新日期：2017-07-01 00:00:00

abstract：:Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...

journal_title：Oncology letters

authors： Cui L,Xu L,Wang G,Wen J,Luo L,Zhao H,Chen S,Zheng M,Sun C,Jin X,Yang L

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRs) are a group of short, endogenous, non-protein-coding and single-stranded RNAs that regulate gene expression by binding to the 3'-untranslated region (3'UTR) of mRNAs, which results in their degradation or translational repression. The aim of the present study was to investigate the expression and func...

journal_title：Oncology letters

authors： Kan Q,Su Y,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is upregulated in various solid tumors and serves a critical role in the tumorigenesis of cancer. However, to the best of our knowledge, the expression of circulating DLX6-AS1 and its role in the diagnosis of non-small cell lung cancer (NSCLC) have not been previously ...

journal_title：Oncology letters

authors： Zhang X,Guo H,Bao Y,Yu H,Xie D,Wang X

更新日期：2019-11-01 00:00:00

abstract：:Tricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 pati...

journal_title：Oncology letters

authors： Feng Z,Zhu HG,Wang LZ,Zheng JW,Chen WT,Zhang Z,Dong W,Qu W,Wang YA

更新日期：2014-02-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...

journal_title：Oncology letters

authors： Ke X,Chen C,Song Y,Cai Q,Li J,Tang Y,Han X,Qu W,Chen A,Wang H,Xu G,Liu D

更新日期：2019-12-01 00:00:00

abstract：:Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...

journal_title：Oncology letters

authors： Jiang P,Yu G,Zhang Y,Xiang Y,Zhu Z,Feng W,Lee W,Zhang Y

更新日期：2014-05-01 00:00:00