Abstract:
:Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. The expression of cyclin E was evaluated in 49 patients. Using a multivariate analysis, the expression of cyclin E in the tumor at diagnosis was compared with various clinicopathological variables, including age, gender, tumor site, tumor size, tumor differentiation and lymph node involvement. There were more node-positive cases in the cyclin E-negative group than in the cyclin E-positive group (P=0.003). However, there was no correlation between the degree of cyclin E expression and the clinical data. In conclusion, our data suggest that overexpression of cyclin E does not predict the clinical outcome in colorectal cancer stage III. Negative cyclin E staining may be associated with lymph node involvement.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Rath-Wolfson L,Bergman M,Ori Y,Goldman A,Ram E,Koren R,Salman Hdoi
10.3892/ol.2012.955subject
Has Abstractpub_date
2013-01-01 00:00:00pages
145-148issue
1eissn
1792-1074issn
1792-1082pii
ol-05-01-0145journal_volume
5pub_type
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