Abstract:
:Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation between abnormal expression of TFF2 and gastric cancer progression. TFF2 expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR), quantitative PCR (qPCR), and western blot and immunohistochemistry analyses. TFF2 methylation levels were analyzed by genomic bisulfite sequencing method. The results showed that TFF2 mRNA and protein expression were decreased in gastric cancer tissues compared with the matched non-cancerous mucosa, and the decreased level was associated with the differentiation and invasion of gastric cancer. Moreover, the average TFF2 methylation level of CpG sites in the promoter region was 70.4% in three gastric cancer tissues, while the level in associated non-neoplastic tissues was 41.0%. Furthermore, the promoter hypermethylation of TFF2 was also found in gastric cancer cell lines, AGS and N87, and gene expression was significantly increased following treatment with a demethylating agent, 5-Aza-2'-deoxycytidine. In conclusion, TFF2 expression was markedly decreased in gastric cancer and promoter hypermethylation was found to regulate the downregulation of TFF2. TFF2 has been suggested as a tumor suppressor in gastric carcinogenesis and metastasis.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jiang P,Yu G,Zhang Y,Xiang Y,Zhu Z,Feng W,Lee W,Zhang Ydoi
10.3892/ol.2014.1904subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1525-1531issue
5eissn
1792-1074issn
1792-1082pii
ol-07-05-1525journal_volume
7pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4628
更新日期:2016-07-01 00:00:00
abstract::The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5477
更新日期:2017-02-01 00:00:00
abstract::Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2920
更新日期:2015-04-01 00:00:00
abstract::Leiomyosarcomas account for ~24% of all adult sarcomas, and develop predominantly either in the uterus [uterine leiomyosarcoma (ULMS)] or in deep soft tissue or the retroperitoneum [non-uterine leiomyosarcoma (NULMS)]. Leiomyosarcomas are relatively chemoresistant tumors, and the prognosis of patients with leiomyosarc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7274
更新日期:2018-01-01 00:00:00
abstract::Ductal adenocarcinoma of the prostate (DAP) is a rare variant of prostate cancer, and has poorly-identified clinical characteristics. Few cases have been previously reported in Chinese males and DAP is more commonly reported in Caucasian males over 70-years of age. In the present study, a 55-year-old Chinese male pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4098
更新日期:2016-02-01 00:00:00
abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8724
更新日期:2018-07-01 00:00:00
abstract::Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidenc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1555
更新日期:2013-11-01 00:00:00
abstract::For individualized bevacizumab-based therapy, non-invasive biomarkers are necessary. This study assessed the predictive value of plasma vascular endothelial growth factor (VEGF)-A, soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 levels as biomarkers for clinical response and survival in advanced colorectal cancer (CRC) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000045
更新日期:2010-03-01 00:00:00
abstract::A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, part...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7742
更新日期:2018-03-01 00:00:00
abstract::The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8425
更新日期:2018-06-01 00:00:00
abstract::Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell lin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12321
更新日期:2021-01-01 00:00:00
abstract::The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9897
更新日期:2019-03-01 00:00:00
abstract::Pancreatic cancer is one of the most frequently occurring malignancies worldwide and it is the fourth most common cause of cancer-associated mortality in Western countries. Thalidomide (THD) plays an important role in tumor therapy, as it is able to promote early stage apoptosis and inhibit the process of angiogenesis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3064
更新日期:2015-05-01 00:00:00
abstract::The present study aimed to assess the feasibility, safety and efficiency of ultrasound-guided percutaneous microwave ablation (MWA) on liver metastases from colon or rectal cancer. Patients who received MWA therapy for liver metastases from colon or rectal cancer between June 2009 and May 2012 were enrolled in the stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2106
更新日期:2014-07-01 00:00:00
abstract::Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11406
更新日期:2020-04-01 00:00:00
abstract::Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11948
更新日期:2020-10-01 00:00:00
abstract::Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the mai...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4443
更新日期:2016-06-01 00:00:00
abstract::Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6801
更新日期:2017-10-01 00:00:00
abstract::Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7329
更新日期:2018-01-01 00:00:00
abstract::Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10718
更新日期:2019-10-01 00:00:00
abstract::N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in hepatocellular carcinoma (HCC) cells remains controversial. The present study investigated the role of NDRG1 in HCC as well as its molecular mechanism using a range of t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5924
更新日期:2017-05-01 00:00:00
abstract::The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5673
更新日期:2017-03-01 00:00:00
abstract::The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.690
更新日期:2012-07-01 00:00:00
abstract::DNA hypermethylation plays a major role in the regulation of gene expression in differentiation, development and diseases. The DNA mismatch repair system, which includes Mut-S-Homologon-2 (MSH2) protein, is essential to maintain the stability of the genome during repeated duplication. This study aimed to investigate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2482
更新日期:2014-11-01 00:00:00
abstract::Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4659
更新日期:2016-07-01 00:00:00
abstract::We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings sug...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.194
更新日期:2010-11-01 00:00:00
abstract::The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltratin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11750
更新日期:2020-08-01 00:00:00
abstract::Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7259
更新日期:2017-12-01 00:00:00
abstract::Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literatur...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3891
更新日期:2016-01-01 00:00:00