Time profile of nimotuzumab for enhancing radiosensitivity of the Eca109 cell line.

abstract：:A previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate...

journal_title：Oncology letters

authors： Shi Z,Guo F,Jia D,Huang J,Chen J,Sun M,Qi F,Liang C

更新日期：2019-10-01 00:00:00

abstract：:The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...

journal_title：Oncology letters

authors： Sugiyama T,Iwaizumi M,Kaneko M,Tani S,Yamade M,Hamaya Y,Furuta T,Miyajima H,Osawa S,Baba S,Maekawa M,Sugimoto K

更新日期：2020-09-01 00:00:00

abstract：:Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...

journal_title：Oncology letters

authors： Wang ZP,Tian Y,Lin J

更新日期：2017-10-01 00:00:00

abstract：:The clinical resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been linked to EGFR T790M resistance mutations or MET amplifications. Additional mechanisms underlying EGFR-TKI drug resistance remain unclear. The present study demonstrated t...

journal_title：Oncology letters

authors： Zhai Y,Zhang Y,Nan K,Liang X

更新日期：2017-05-01 00:00:00

abstract：:Although previous studies have demonstrated that Glut-1 is the predominant glucose transporter, is significantly overexpressed in various types of tumor and is correlated with poor prognosis, the potential function and clinical value of Glut-1 expression in osteosarcoma remains largely unclear. In particular, the pros...

journal_title：Oncology letters

authors： Fan J,Mei J,Zhang MZ,Yuan F,Li SZ,Yu GR,Chen LH,Tang Q,Xian CJ

更新日期：2017-08-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell ...

journal_title：Oncology letters

authors： Kita H,Okamoto K,Kushima R,Kawauchi A,Chano T

更新日期：2015-08-01 00:00:00

abstract：:It has been demonstrated that microRNA-497 (miR-497) acts as a tumor suppressor and is involved in tumor progression, development and metastasis in several types of cancer. However, little is known about the exact role of miR-497 in osteosarcoma (OS). The aim of the current study was to investigate the potential role ...

journal_title：Oncology letters

authors： Ge L,Zheng B,Li M,Niu L,Li Z

更新日期：2016-03-01 00:00:00

abstract：:The expression levels of cyclooxygenase (COX)-2 and the prostaglandin E2 (PGE2) content have been associated with poor prognosis in patients with colorectal cancer (CRC). There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on t...

journal_title：Oncology letters

authors： Cervantes-Madrid DL,Nagi S,Asting Gustafsson A

更新日期：2017-03-01 00:00:00

abstract：:The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...

journal_title：Oncology letters

authors： Zhou Y,Zou H,Wu E,Huang L,Yin R,Mei Y,Zhu X

更新日期：2018-08-01 00:00:00

abstract：:Malignant transformation of an epidermoid cyst is rare. The current report presents a case of a 55-year-old female patient with squamous cell carcinoma arising from a benign epidermoid cyst in the left temporal region and prepontine area. She had undergone subtotal resection of an epidermoid cyst 7 months previously. ...

journal_title：Oncology letters

authors： Ding S,Jin Y,Jiang J

更新日期：2016-05-01 00:00:00

abstract：:Ovarian cancer (OC) has the worst prognosis among all malignancy types in females worldwide according to epidemiological studies in 2017. Although radiotherapy, chemotherapy and surgical treatment are the most common treatment methods, their curative effects are not satisfactory. The present study aimed to examine the...

journal_title：Oncology letters

authors： Wang Y,Yang X,Xian S,Zhang L,Cheng Y

更新日期：2019-07-01 00:00:00

abstract：:The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical ...

journal_title：Oncology letters

authors： Wu S,Chen H

更新日期：2018-09-01 00:00:00

abstract：:Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB)...

journal_title：Oncology letters

authors： Tian X,Wang Y,Liu Y,Yin J,Chen D,Ke X,Ma W

更新日期：2018-10-01 00:00:00

abstract：:The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...

journal_title：Oncology letters

authors： He S,Fan X,Ma H,Xiaerfuhazi H,Rehato A,Feng J,Shi X,He F

更新日期：2019-08-01 00:00:00

abstract：:Dendrobium candidum Wall ex Lindl. (D. candidum) is a traditional Chinese medicine widely used in Asia. The present study has showed that D. candidum exerted an anti-metastatic effect in mice injected with 26-M3.1 colon carcinoma cells. D. candidum showed the most marked tumor inhibitory rate of 64.5% at a dose of 400...

journal_title：Oncology letters

authors： Li G,Sun P,Zhou Y,Zhao X,Chen F

更新日期：2014-10-01 00:00:00

abstract：:Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in col...

journal_title：Oncology letters

authors： Liu W,Wu M,Du H,Shi X,Zhang T,Li J

更新日期：2018-04-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:Some colorectal cancer liver metastases (CLMs) disappear on serial imaging during chemotherapy and the optimal treatment strategy for such lesions remains undetermined. The purpose of this study was to investigate the outcome in disappearing CLMs, as few studies have focused on this topic, with conflicting results. Am...

journal_title：Oncology letters

authors： Ono T,Ishida H,Kumamoto K,Okada N,Ishibashi K

更新日期：2012-11-01 00:00:00

abstract：:Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

journal_title：Oncology letters

authors： Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...

journal_title：Oncology letters

authors： Yan J,Wen J,Wei ZD,Li XS,Li P,Xiao SW

更新日期：2018-04-01 00:00:00

abstract：:Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS present...

journal_title：Oncology letters

authors： Nakamura K,Nakayama K,Ishikawa M,Ishikawa N,Katagiri H,Katagiri A,Ishibashi T,Sato E,Iida K,Sultana R,Kyo S

更新日期：2016-11-01 00:00:00

abstract：:Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...

journal_title：Oncology letters

authors： Annovazzi L,Mellai M,Bovio E,Mazzetti S,Pollo B,Schiffer D

更新日期：2018-01-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...

journal_title：Oncology letters

authors： Xie CQ,Zhou P,Zuo J,Li X,Chen Y,Chen JW

更新日期：2016-11-01 00:00:00

abstract：:Hypoxic microenvironments and angiogenesis have been a focus of tumor research in previous years. The aim of the the present study was to create a hypoxic model and observe the effect of hypoxia on the expression of hypoxia inducible factor-1α (HIF-1α), insulin-like growth factor I (IGF-1) and vascular endothelial gro...

journal_title：Oncology letters

authors： Liu Q,Xu Z,Mao S,Chen W,Zeng R,Zhou S,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...

journal_title：Oncology letters

authors： Kasai S,Sasaki T,Watanabe A,Nishiya M,Yasuhira S,Shibazaki M,Maesawa C

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...

journal_title：Oncology letters

authors： Zhang S,Ma Y,Jiang J,Dai Z,Gao X,Yin X,Xi W,Min W

更新日期：2014-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer worldwide. However, operative diagnostic and prognostic systems for ESCC remain to be established. To improve assessment of the prognosis for patients with ESCC, the present study developed an online consensus survival tool for ESCC, t...

journal_title：Oncology letters

authors： Wang Q,Wang F,Lv J,Xin J,Xie L,Zhu W,Tang Y,Li Y,Zhao X,Wang Y,Li X,Guo X

更新日期：2019-08-01 00:00:00

abstract：:Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell line GLAG-66 and GLAG-66 ...

journal_title：Oncology letters

authors： Zhang H,Yang L,Liu Z,Liu C,Teng X,Zhang L,Yin B,Liu Z

更新日期：2017-09-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to i...

journal_title：Oncology letters

authors： Zhou W,Zhu W,Ma L,Xiao F,Qian W

更新日期：2015-11-01 00:00:00