Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis.

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00

abstract：:The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...

journal_title：Oncology letters

authors： Inoue Y,Tanaka K,Hiro J,Toiyama Y,Miki C,Kusunoki M

更新日期：2010-01-01 00:00:00

abstract：:Wiskott-Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer. However, to the best of our knowledge, the expression profile of WASF3 and its correlations with the c...

journal_title：Oncology letters

authors： Wu J,Wang GC,Chen XJ,Xue ZR

更新日期：2014-09-01 00:00:00

abstract：:In the present study, the function and mechanism of cytokine-induced killer cells (CIK) combined with dendritic cells (DC-CIK) were examined in Lewis lung cancer (LLC) cells. Co-culture of CIK dendritic cells (DC) in vitro was used to investigate their proliferation and the antitumor effects on LLC cells. DC and CIK c...

journal_title：Oncology letters

authors： Hou Y,Zang D,Li X,Li F

更新日期：2018-08-01 00:00:00

abstract：:Lung is one of the most common sites for bladder cancer to metastasize. Although the involvement of the epithelial-to-mesenchymal transition (EMT) in bladder cancer progression has been established, the mechanism of EMT induction remains unclear. In order to investigate this, T24-parental (P) and T24-lung (L) bladder ...

journal_title：Oncology letters

authors： Zhu J,Huang Z,Zhang M,Wang W,Liang H,Zeng J,Wu K,Wang X,Hsieh JT,Guo P,Fan J

更新日期：2018-03-01 00:00:00

abstract：:To determine the radiosensitizing effect of apatinib on esophageal cancer cells, and to preliminarily investigate the underlying mechanism, KYSE-150 cells were treated with apatinib, x-ray or apatinib combined with x-ray, and compared with a blank control. It was observed that apatinib significantly inhibited vascular...

journal_title：Oncology letters

authors： Hu L,Sun F,Sun Z,Ni X,Wang J,Wang J,Zhou M,Feng Y,Kong Z,Hua Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

journal_title：Oncology letters

authors： Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

更新日期：2018-07-01 00:00:00

abstract：:Previous studies have demonstrated an association between human papillomavirus (HPV) and mutations in the epidermal growth factor receptor (EGFR) gene in lung cancer patients; however, few studies have investigated this association in advanced lung adenocarcinoma patients undergoing gefitinib treatment. The present st...

journal_title：Oncology letters

authors： Li M,Deng F,Qian LT,Meng SP,Zhang Y,Shan WL,Zhang XL,Wang BL

更新日期：2016-09-01 00:00:00

abstract：:Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...

journal_title：Oncology letters

authors： Kim MY

更新日期：2020-04-01 00:00:00

abstract：:The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinor...

journal_title：Oncology letters

authors： Wang Y,Ha M,Liu J,Li P,Zhang W,Zhang X

更新日期：2016-02-01 00:00:00

abstract：:There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...

journal_title：Oncology letters

authors： Jiang X,Wang Z

更新日期：2018-09-01 00:00:00

abstract：:Esophageal cancer staging is important for the treatment of esophageal cancer. Endoscopic ultrasonography (EUS) is a common diagnostic tool for esophageal cancer prior to surgery. However, EUS is unable to accurately discriminate the N-staging of lymph nodes. In order to distinguish an optimized standard for malignant...

journal_title：Oncology letters

authors： Zhang Y,He S,Dou L,Liu Y,Ke Y,Yu X,Wang Z,Wang G

更新日期：2019-01-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00

abstract：:As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...

journal_title：Oncology letters

authors： Zou Y,Yang J,Wu J,Luo C,Huang Y

更新日期：2018-01-01 00:00:00

abstract：:Ovarian cancer is the most common gynecological malignant cancer in female genitalia. Dysregulation or dysfunction of microRNAs (miRs) contribute to cancer development. The role of miR-520b in ovarian cancer remains unclear. The present study investigated the role of miR-520b in ovarian cancer and determined that the ...

journal_title：Oncology letters

authors： Guan R,Cai S,Sun M,Xu M

更新日期：2017-09-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

journal_title：Oncology letters

authors： Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

更新日期：2016-12-01 00:00:00

abstract：:Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...

journal_title：Oncology letters

authors： Kato T,Nakayama R,Haba T,Kawaguchi M,Komiya A,Koike H

更新日期：2018-11-01 00:00:00

abstract：:HER2 amplification occurs in ~20% of gastric cancer (GC) cases; however, in gastric and gastroesophageal junction cancer with HER2 gene amplification, trastuzumab in combination with cisplatin (DDP)-based chemotherapy has been reported to improve the oncological outcome. The aim of the present study was to evaluate th...

journal_title：Oncology letters

authors： Liu Y,Ling Y,Qi Q,Zhu M,Wan M,Zhang Y,Zhang C

更新日期：2015-02-01 00:00:00

abstract：:The present study aimed to examine the impact of sarcopenia, defined as low muscle mass on computed tomography (CT), prior to sorafenib therapy on the clinical outcomes of patients with hepatocellular carcinoma (HCC) receiving sorafenib therapy. In total, 232 patients with unresectable HCC (median age, 72 years) were ...

journal_title：Oncology letters

authors： Nishikawa H,Nishijima N,Enomoto H,Sakamoto A,Nasu A,Komekado H,Nishimura T,Kita R,Kimura T,Iijima H,Nishiguchi S,Osaki Y

更新日期：2017-08-01 00:00:00

abstract：:The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification w...

journal_title：Oncology letters

authors： Huang JX,Zhao K,Lin M,Wang Q,Xiao W,Lin MS,Yu H,Chen P,Qian RY

更新日期：2013-07-01 00:00:00

abstract：:Bladder cancer is one of the most common forms of malignancies involving the urinary system and multiple risk factors have been associated with its etiology. The most common of which include cigarette smoking and various occupational or chemical exposures. It is usually diagnosed in older individuals with an average a...

journal_title：Oncology letters

authors： Khan R,Ibrahim H,Tulpule S,Iroka N

更新日期：2016-05-01 00:00:00

abstract：:Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...

journal_title：Oncology letters

authors： Liu Y,Cao CS,Yu Y,Si YM

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...

journal_title：Oncology letters

authors： Li SY,Ye JY,Meng FY,Li CF,Yang MO

更新日期：2015-07-01 00:00:00

abstract：:Thyroid cancer is the most common malignant endocrine tumor, with significant morbidity and mortality. Bovine myeloid antimicrobial peptide 28 (BMAP-28) is a cathelicidin that is found in bovine neutrophils. In the present study, the effect and relative mechanism of BMAP-28 on the human thyroid cancer TT cell line in ...

journal_title：Oncology letters

authors： Zhang D,Wan L,Zhang J,Liu C,Sun H

更新日期：2015-10-01 00:00:00

abstract：:The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...

journal_title：Oncology letters

authors： Zhao W,Xu H

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to investigate the treatment options for patients with tuberous sclerosis complex (TSC)-associated renal angiomyolipomas (AMLs). A total of 17 patients who were consecutively diagnosed with TSC-associated renal AMLs at the Department of Urology of Zhongshan Hospital between 1998 and 20...

journal_title：Oncology letters

authors： Wang H,Long Q,Wang Y,Liu L,Zhou L,Guo J

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...

journal_title：Oncology letters

authors： Yang X,Cai W,Yang Q,Lu Z,Li J,Yu J

更新日期：2015-10-01 00:00:00

abstract：:Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...

journal_title：Oncology letters

authors： Li W,Wang Z,Chen Y,Wang K,Lu T,Ying F,Fan M,Li Z,Wu J

更新日期：2017-04-01 00:00:00

abstract：:Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...

journal_title：Oncology letters

authors： Wang J,Deng Q,Jiang YY,Zhang R,Zhu HB,Meng JX,Li YM

更新日期：2019-11-01 00:00:00