Abstract:
:Thyroid cancer is the most common malignant endocrine tumor, with significant morbidity and mortality. Bovine myeloid antimicrobial peptide 28 (BMAP-28) is a cathelicidin that is found in bovine neutrophils. In the present study, the effect and relative mechanism of BMAP-28 on the human thyroid cancer TT cell line in vitro and in vivo were investigated. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and a TT-xenograft mouse model were used in this study. The data obtained indicated that BMAP-28 significantly inhibited the proliferation of the TT cells in vitro. In addition, the Annexin V-fluorescein isothiocyanate/propidium iodide assay detected that BMAP-28 induced apoptotic effects in the TT cells. Moreover, the expression of activated caspase-3 and -9 was upregulated at the transcriptional and translational levels. Simultaneously, the expression of matrix metalloproteinase (MMP)3 and MMP9 was downregulated following BMAP-28 treatment. Finally, BMAP-28 significantly prevented the tumor growth in the TT-xenograft mouse model. These results indicated that BMAP-28 could be a potential agent for the treatment of thyroid cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhang D,Wan L,Zhang J,Liu C,Sun Hdoi
10.3892/ol.2015.3612subject
Has Abstractpub_date
2015-10-01 00:00:00pages
2620-2626issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-3612journal_volume
10pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::To investigate the prospective roles and the clinicopathological application of microRNA-21-5p (miR-21-5p) in hepatocellular carcinoma (HCC), the present review is based on 24 studies and bioinformatics investigation. Firstly, HCC-associated miR-21-5p data were aggregated from literature databases and two public genom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9627
更新日期:2019-01-01 00:00:00
abstract::Gallbladder cancer (GBC) is a rare but highly aggressive cancer for which no well-accepted prognostic biomarkers have been identified. Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, and integrin α6 (ITGA6), also known as CD49f, are important molecules in cancer and putative markers of v...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5341
更新日期:2016-12-01 00:00:00
abstract::This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7142
更新日期:2017-12-01 00:00:00
abstract::The present study aimed to investigate the feasibility of using ecto-mesenchymal stem cell (EMSC)-derived dendritic cells (DCs) for glioma immunotherapy following infection by a recombinant adenovirus containing the melanoma-associated antigen D4a (MAGE-D4a) gene. The ex vivo cultured EMSCs were infected by the adenov...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4306
更新日期:2016-04-01 00:00:00
abstract::Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8095
更新日期:2018-05-01 00:00:00
abstract::Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung d...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2978
更新日期:2015-05-01 00:00:00
abstract::Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000137
更新日期:2010-09-01 00:00:00
abstract::The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.342
更新日期:2011-09-01 00:00:00
abstract::Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11829
更新日期:2020-09-01 00:00:00
abstract::Cervical cancer pathogenesis is regulated by numerous factors, including microRNAs. MicroRNA 1246 (miR-1246) has been shown to serve a role in cervical cancer tumorigenesis. However, the mechanisms through which miR-1246 exerts its oncogenic effects are largely unknown. The aim of the current study was to evaluate the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10571
更新日期:2019-09-01 00:00:00
abstract::Resistance to apoptosis is an characteristic of cancer cells that serves a critical function in tumor development and represents a target for antitumor therapy. Isoimperatorin (ISOIM), a coumarin compound, exhibits antitumor functions in multiple types of tumor cells. However, its antitumor effects and molecular mecha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8303
更新日期:2018-05-01 00:00:00
abstract::Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.918
更新日期:2012-12-01 00:00:00
abstract::Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1566
更新日期:2013-11-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from Garcinia hanburyi, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5284
更新日期:2016-12-01 00:00:00
abstract::Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9677
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein mi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5338
更新日期:2016-12-01 00:00:00
abstract::Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8027
更新日期:2018-04-01 00:00:00
abstract::The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1072
更新日期:2013-02-01 00:00:00
abstract::The present study aimed to retrospectively review the contribution of 18F-fluorodeoxygluose-positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of biochemical recurrence in patients with a diagnosis of local-stage prostate cancer (PCa) who underwent radical prostatectomy (RP) or receive...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3903
更新日期:2016-01-01 00:00:00
abstract::Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10802
更新日期:2019-11-01 00:00:00
abstract::Isolated cortical vein thrombosis (ICoVT) is a rare form of cerebral venous thrombosis and is easily misdiagnosed as brain tumor due to its atypical clinical presentations and radiological findings similar to brain tumors. The present study focused on 4 patients with ICoVT, 2 men and 2 women. In the 2 male patients, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3931
更新日期:2016-01-01 00:00:00
abstract::Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5953
更新日期:2017-06-01 00:00:00
abstract::Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12033
更新日期:2020-11-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence and mortality rates are increasing worldwide. Mortalin is a highly conserved chaperone protein involved in multiple pathological and physiological processes, including anti-apoptosis, carcinogenesis and metastasis. The Bcl-2 famil...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7570
更新日期:2018-02-01 00:00:00
abstract::The concentrations required for curcumin to exert its anticancer activity (IC50, 20 µM) are difficult to achieve in the blood plasma of patients, due to the low bioavailability of the compound. Therefore, much effort has been devoted to the development of curcumin analogues that exhibit stronger anticancer activity an...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4536
更新日期:2016-06-01 00:00:00
abstract::The detection and characterisation of tumour-derived circulating epithelial tumor cells (CETCs) or circulating tumor cells (CTCs) have been a main focus of basic oncological research over previous years. Numerous studies in the past decade have shown that CTCs are a promising tool for the estimation of the risk for me...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4878
更新日期:2016-09-01 00:00:00
abstract::The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6606
更新日期:2017-09-01 00:00:00
abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8902
更新日期:2018-08-01 00:00:00
abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell lin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12321
更新日期:2021-01-01 00:00:00