Effects of isoimperatorin on proliferation and apoptosis of human gastric carcinoma cells.

abstract：:The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...

journal_title：Oncology letters

authors： Ye J,Wang J,Zhang N,Liu Y,Tan L,Xu L

更新日期：2018-05-01 00:00:00

abstract：:Meningiomas may be classified as neurofibromin 2 (NF2)-associated and non-NF2 meningiomas depending on the presence or absence of molecular alterations in the NF2 gene. One of the characteristic histological features of meningiomas is the whorl formation of neoplastic arachnoid cells. NF2 is a human homolog of the Dro...

journal_title：Oncology letters

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2016-11-01 00:00:00

abstract：:The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vit...

journal_title：Oncology letters

authors： Jiao H,Zeng L,Zhang J,Yang S,Lou W

更新日期：2020-03-01 00:00:00

abstract：:Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and r...

journal_title：Oncology letters

authors： Dong G,Mao Q,Xia W,Xu Y,Wang J,Xu L,Jiang F

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...

journal_title：Oncology letters

authors： Al-Muhtaseb SI

更新日期：2014-12-01 00:00:00

abstract：:Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation ente...

journal_title：Oncology letters

authors： Sugita S,Inomata M,Kono Y,Shiroshita H,Etoh T,Shiraishi N,Kitano S

更新日期：2013-11-01 00:00:00

abstract：:The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was deter...

journal_title：Oncology letters

authors： Zhang S,Lei R,Wu J,Shan J,Hu Z,Chen L,Ren X,Yao L,Wang J,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer effects. Meloxicam is an NSAID that is widely used in human and veterinary medicine. High concentrati...

journal_title：Oncology letters

authors： Iturriaga MP,Paredes R,Arias JI,Torres CG

更新日期：2017-08-01 00:00:00

abstract：:Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the mai...

journal_title：Oncology letters

authors： Liu W,Meng Z,Liu H,Li W,Wu Q,Zhang X,E C

更新日期：2016-06-01 00:00:00

abstract：:The incidence and mortality rates of gastric cancer rank among the highest five of all cancer types worldwide. The chemotherapeutic agent 5-fluorouracil (5-FU) is the gold standard for treating gastric cancer, but its efficacy is limited due to high rates of resistance. To improve the therapeutic efficacy of 5-FU and ...

journal_title：Oncology letters

authors： Lee S,Lee SK,Jung J

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...

journal_title：Oncology letters

authors： Li J,Wang L,Qiu Z,Su Y

更新日期：2019-03-01 00:00:00

abstract：:Cardiac toxicity has been the major concern when using doxorubicin (DOX) in cancer therapy. Thrombopoietin (TPO) protects cardiac cells from DOX-induced cell damage; however, its molecular mechanism remains exclusive. The anti-autophagic and anti-apoptotic effects of TPO upon DOX treatment were studied in the cardiac ...

journal_title：Oncology letters

authors： Wang H,Wang H,Liang EY,Zhou LX,Dong ZL,Liang P,Weng QF,Yang M

更新日期：2018-01-01 00:00:00

abstract：:Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β-catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear loca...

journal_title：Oncology letters

authors： Apelt N,Hubertus J,Mayr D,Graf N,Furtwängler R,Von Schweinitz D,Kappler R

更新日期：2016-10-01 00:00:00

abstract：:KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...

journal_title：Oncology letters

authors： Lee HS,Hwang DY,Han HS

更新日期：2020-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2019.10030.]. ...

journal_title：Oncology letters

authors： Wang S,Meng C,Jiang Z,Gonzalez-Rivas D,Ruan J,Xu W,Liu C,Zhang L,Gao G,Yu G,Teng H,Ju J

更新日期：2020-04-01 00:00:00

abstract：:The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...

journal_title：Oncology letters

authors： Loilome W,Kadsanit S,Muisook K,Yongvanit P,Namwat N,Techasen A,Puapairoj A,Khuntikeo N,Phonjit P

更新日期：2017-02-01 00:00:00

abstract：:Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...

journal_title：Oncology letters

authors： Calaf GM,Ponce-Cusi R,Aguayo F,Muñoz JP,Bleak TC

更新日期：2020-07-01 00:00:00

abstract：:Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-i...

journal_title：Oncology letters

authors： Zhang XY,Zhang PY

更新日期：2016-11-01 00:00:00

abstract：:MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...

journal_title：Oncology letters

authors： Wang G,Zhao R,Zhao X,Chen XI,Wang D,Jin Y,Liu XI,Zhao CI,Zhu Y,Ren C,Li M,Jin X,Zhang F,Zhong Z,Wang T,Li X

更新日期：2015-11-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

journal_title：Oncology letters

authors： He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

更新日期：2014-05-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...

journal_title：Oncology letters

authors： He J,Mu M,Luo Y,Wang H,Ma H,Guo S,Fang Q,Qian Z,Lu H,Song C

更新日期：2019-03-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is rare in the adult population and even rarer with jaw involvement. The current study presents the case of a 39-year-old male who complained of recurrent pain, swelling of the gingiva and an occasional pus-like discharge in the right mandible for one year. The patient was previousl...

journal_title：Oncology letters

authors： Shi S,Liu Y,Fu T,Li X,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:High-fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin-linked kinase (ILK), β-parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study w...

journal_title：Oncology letters

authors： Hu MB,Hu JM,Jiang LR,Yang T,Zhu WH,Hu Y,Wu XB,Jiang HW,Ding Q

更新日期：2018-10-01 00:00:00

abstract：:We investigated the possible association between DLKI gene promoter region methylation and the increased invasion capacity of non-small cell lung cancer (NSCLC). Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells....

journal_title：Oncology letters

authors： Zhong Z,Ye Y,Guo W,He Y,Hu W

更新日期：2017-06-01 00:00:00

abstract：:The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had os...

journal_title：Oncology letters

authors： Sun Y,Liu X,Pan S,Deng C,Li X,Guo Q

更新日期：2017-11-01 00:00:00

abstract：:DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the associati...

journal_title：Oncology letters

authors： Feng Y,Zhang H,Gao W,Wen S,Huangfu H,Sun R,Bai W,Wang B

更新日期：2014-10-01 00:00:00

abstract：:Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...

journal_title：Oncology letters

authors： Wang N,Bu Q,Liu Q,Yang J,He H,Liu J,Ren X,Lyu J

更新日期：2019-08-01 00:00:00

abstract：:Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...

journal_title：Oncology letters

authors： Inoue Y,Matsumoto H,Yamada S,Kawai K,Suemizu H,Gika M,Takanami I,Iwazaki M,Nakamura M

更新日期：2010-09-01 00:00:00

abstract：:Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...

journal_title：Oncology letters

authors： Li X,Rui B,Cao Y,Gong X,Li H

更新日期：2020-03-01 00:00:00