Abstract:
:Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-induced genetic aberrations that stimulate skin melanocytes to develop unlimited growth. This eventually leads to cell immortality, which in turn causes metastases. The present review examines the genetics and epigenetics of this pathological state together with recent perspectives of the therapeutic management of disease.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhang XY,Zhang PYdoi
10.3892/ol.2016.5093subject
Has Abstractpub_date
2016-11-01 00:00:00pages
3041-3044issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-5093journal_volume
12pub_type
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