Abstract:
:The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein microtubule-associated protein 1 light chain 3α (GFP-LC3) protein aggregates were observed under a confocal microscope, and Ishikawa and HEC-1A cell apoptosis was detected using flow cytometry. The expression levels of LC3-I, LC3-II and mTOR proteins were detected by western blot analysis. The results showed that RAD001 effectively inhibited human endometrial cancer Ishikawa and HEC-1A cell proliferation via downregulation of AKT/mTOR phosphorylation. Moreover, RAD001 induced autophagic cell death and a higher sensitivity to paclitaxel-induced apoptosis. These results indicate that RAD001 could have therapeutic potential in human endometrial cancer with hyperactivated AKT/mTOR signaling.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang H,Li D,Li X,Ou X,Liu S,Zhang Y,Ding J,Xie Bdoi
10.3892/ol.2016.5338subject
Has Abstractpub_date
2016-12-01 00:00:00pages
5029-5035issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-5338journal_volume
12pub_type
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