Abstract:
:The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DNA methylation status was determined by methylation-specific PCR and protein was detected using western blotting. The results of the present study demonstrated that SFRP1 was methylated in the bladder cancer cell lines T24 and 5637, but not in SCaBER cells. After treating T24 and 5637 cells with a demethylating agent, the cells expressed SFRP1 mRNA and protein. Among the 45 patients with bladder cancer, methylation of SFRP1 was detected in 28 patients (62.2%). Of the matched cancer-adjacent tissues, 6 (13.3%) were found to have methylated SFRP1. The result is statistically significant (P<0.01). In conclusion, SFRP1 is downregulated in certain bladder cancer patients as a consequence of methylation. SFRP1 methylation may be involved in the pathogenesis of bladder cancer via excessive activation of the Wnt signaling pathway.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang X,Wang H,Bu R,Fei X,Zhao C,Song Ydoi
10.3892/ol.2012.713subject
Has Abstractpub_date
2012-08-01 00:00:00pages
334-338issue
2eissn
1792-1074issn
1792-1082pii
ol-04-02-0334journal_volume
4pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5449
更新日期:2017-01-01 00:00:00
abstract::microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8609
更新日期:2018-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a serious threat to human health. Chemotherapy drugs such as cisplatin are widely used in cancer treatment, but can cause severe side effects. Hydroxyl safflower yellow A (HSYA) is a water-soluble chalcone glycoside substance extracted from safflowers (Carthamus tinctorius L.) that ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9946
更新日期:2019-03-01 00:00:00
abstract::Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8916
更新日期:2018-08-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a common type of rheumatoid disease, which has recently been demonstrated to be associated with the expression of matrix metalloproteinase (MMP)-2. The aim of the present study was to investigate whether MMP-2 interference reduced the osteogenic differentiation of fibroblasts and to expl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7714
更新日期:2018-03-01 00:00:00
abstract::Xeroderma pigmentosum group C (XPC) is a DNA-damage-recognition gene active at the early stage of DNA repair. XPC also participates in regulation of cell-cycle checkpoint and DNA-damage-induced apoptosis. In the present study, the expression levels of genes involved in nucleotide excision repair (NER) were assessed in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8127
更新日期:2018-05-01 00:00:00
abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.603
更新日期:2012-05-01 00:00:00
abstract::The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9270
更新日期:2018-10-01 00:00:00
abstract::microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1375
更新日期:2013-08-01 00:00:00
abstract::Solamargine (SM), a steroidal alkaloid glycoside purified from the Chinese traditional herb Solanum incanum, is known to possess various biological activities. However, only a few previous studies have reported the anti-metastatic activity of SM. In the present study, the inhibitory effects of SM on metastatic action ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6147
更新日期:2017-07-01 00:00:00
abstract::The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10166
更新日期:2019-06-01 00:00:00
abstract::The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6443
更新日期:2017-08-01 00:00:00
abstract::Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10402
更新日期:2019-08-01 00:00:00
abstract::Primary hemangioendotheliomas (HEs) of the spleen are rare, low-grade borderline-malignant vascular tumors. To date, only a few splenic HE cases have been reported in adults. In infants, one 9-year-old male patient has previously been reported, and the patient succumbed to the disease shortly following surgery. Curren...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2693
更新日期:2015-01-01 00:00:00
abstract::Central diabetes insipidus (DI) is a rare complication in patients with acute myeloid leukemia (AML), typically occurring in patients with abnormalities of chromosomes 3 or 7. The association between AML with monosomy 7 and DI has been described in a number of studies; however, DI has been rarely reported in cases of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3139
更新日期:2015-06-01 00:00:00
abstract::Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in the ubiquitin-proteasome pathway, has been reported to be overexpressed in certain tumor types and to have an important role in the Fanconi anemia pathway. In the present study, the expression of UBE2T and its association with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5237
更新日期:2016-12-01 00:00:00
abstract::Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8726
更新日期:2018-07-01 00:00:00
abstract::The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9394
更新日期:2018-11-01 00:00:00
abstract::DNA hypermethylation plays a major role in the regulation of gene expression in differentiation, development and diseases. The DNA mismatch repair system, which includes Mut-S-Homologon-2 (MSH2) protein, is essential to maintain the stability of the genome during repeated duplication. This study aimed to investigate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2482
更新日期:2014-11-01 00:00:00
abstract::Lung cancer is one of the most lethal types of cancer, and its poor prognosis is primarily due to drug resistance and cancer recurrence. As it is associated with a low five-year survival rate, lung cancer stem cells (LCSCs) have been the subject of numerous recent studies. For these studies of LCSCs, lung cancer cell ...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.8265
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4205
更新日期:2016-03-01 00:00:00
abstract::Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the si...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3323
更新日期:2015-08-01 00:00:00
abstract::Several previous studies have shown that mutations in B-Raf proto-oncogene (BRAF) and telomerase reverse transcriptase (TERT) can be used for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). However, whether mutations in BRAF and the TERT promoter may improve the accurate identification and risk strat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11904
更新日期:2020-10-01 00:00:00
abstract::The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8388
更新日期:2018-06-01 00:00:00
abstract::Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.518
更新日期:2012-03-01 00:00:00
abstract::The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11192
更新日期:2020-02-01 00:00:00
abstract::Human lactoferrin (hLF) is a multifunctional glycoprotein that inhibits cancer growth. However, the inhibitory effect of this glycoprotein in cervical cancer remains inconclusive. This study investigated the efficacy of hLF on the inhibition of U14 cervical cancer in vivo. Recombinant adenovirus carrying hLF (Ad-hLF) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1776
更新日期:2014-03-01 00:00:00
abstract::The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coeffic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6779
更新日期:2017-10-01 00:00:00
abstract::The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2302
更新日期:2014-09-01 00:00:00