miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2.

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00

abstract：:Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...

journal_title：Oncology letters

authors： Lu K,Shen H,Zhu S,Bi S,Wu S

更新日期：2018-08-01 00:00:00

abstract：:Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...

journal_title：Oncology letters

authors： Wu YL,Zhou L,Lu Y

更新日期：2016-08-01 00:00:00

abstract：:It has previously been reported that KU60019, as a highly effective radiosensitizer, inhibits the DNA damage response and blocks radiation-induced phosphorylation of key ataxia telangiectasia mutated targets in human glioma cells. The present study investigated whether KU60019 affects cell physiological activities and...

journal_title：Oncology letters

authors： Zhu Y,Mao C,Wu J,Li S,Ma R,Cao H,Ji M,Jing C,Tang J

更新日期：2014-11-01 00:00:00

abstract：:As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...

journal_title：Oncology letters

authors： Zou Y,Yang J,Wu J,Luo C,Huang Y

更新日期：2018-01-01 00:00:00

abstract：:Lichen sclerosus is a chronic and inflammatory disease. Extensive studies have focused on the epidermis, with the dermis or epidermis-dermis receiving less attention. To investigate the role of galectin-7, a keratinocyte protein, in vulvar lichen sclerosus (VLS) and its potential effects on dermal fibroblasts, immunoh...

journal_title：Oncology letters

authors： Zhao Y,Zhao S,Li H,Qin X,Wu X

更新日期：2018-08-01 00:00:00

abstract：:Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...

journal_title：Oncology letters

authors： Li XM,Luo XG,He JF,Wang N,Zhou H,Yang PL,Zhang TC

更新日期：2018-03-01 00:00:00

abstract：:Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...

journal_title：Oncology letters

authors： Shi Y,Li X,Chen X,Xu Y,Bo G,Zhou H,Liu Y,Zhou G,Wang Z

更新日期：2017-03-01 00:00:00

abstract：:The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...

journal_title：Oncology letters

authors： Zhou Y,Zou H,Wu E,Huang L,Yin R,Mei Y,Zhu X

更新日期：2018-08-01 00:00:00

abstract：:Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis that rarely occurs in the female genital tract. We report a case of SS occurring in the right vulva of a young Japanese female. The tumor was composed of poorly differentiated rounded cell areas, surrounded by fibroblastic spindle-shaped cell areas...

journal_title：Oncology letters

authors： Kawauchi S,Ihara K,Nishikawa K,Sugino N,Takahashi M,Sasaki1 K

更新日期：2012-11-01 00:00:00

abstract：:The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...

journal_title：Oncology letters

authors： Zhang JB,Zhao LR,Cui TX,Chen XW,Yang Q,Zhou YB,Chen ZT,Zhang SX,Sun JG

更新日期：2018-04-01 00:00:00

abstract：:Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the si...

journal_title：Oncology letters

authors： Gamoh S,Akiyama H,Tominaga K,Nakajima M,Kakudo K,Tanaka A,Shimizutani K

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...

journal_title：Oncology letters

authors： Cai T,Guan X,Wang H,Fang Y,Long J,Xie X,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:Recommendations concerning the intake of vitamin D and/or sunlight exposure in the handling of patients with vitamin D deficiency remain a matter of debate. The present study of the German network of dermato-oncologists (Onkoderm e.V.) refers to an inquiry conducted among general practitioners on this and related issu...

journal_title：Oncology letters

authors： Reinhold U,Dirschka T,Hartgens K,Kirchesch H,Ostendorf R,Petering H,Prieur H,Krähn-Senftleben G,Malaisse WJ

更新日期：2012-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in the insulin-like growth factor-1 (IGF-1) receptor signalling pathway during experimental hepatocarcinogenesis. The aim of this study was ...

journal_title：Oncology letters

authors： Aleem E,Elshayeb A,Elhabachi N,Mansour AR,Gowily A,Hela A

更新日期：2012-03-01 00:00:00

abstract：:The lack of hormone receptors in triple negative breast cancer (TNBC) is associated with the inefficacy of anti-estrogen chemotherapies, leaving fewer options for patient treatment and higher mortality rates. Additionally, as with numerous types of inflammatory breast cancer, infiltration of tumor associated macrophag...

journal_title：Oncology letters

authors： Bauer D,Mazzio E,Hilliard A,Oriaku ET,Soliman KFA

更新日期：2020-03-01 00:00:00

abstract：:A previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate...

journal_title：Oncology letters

authors： Shi Z,Guo F,Jia D,Huang J,Chen J,Sun M,Qi F,Liang C

更新日期：2019-10-01 00:00:00

abstract：:The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

journal_title：Oncology letters

authors： Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

更新日期：2016-12-01 00:00:00

abstract：:Cell migration potency is essential in cancer metastasis and is often regulated by extracellular stimuli. Oral squamous cell carcinoma cell lines include those that are sensitive, as well as resistant, to the effects of the epidermal growth factor receptor (EGFR) inhibitor cetuximab on cell migration. In the present s...

journal_title：Oncology letters

authors： Ohnishi Y,Yasui H,Kakudo K,Nozaki M

更新日期：2017-02-01 00:00:00

abstract：:Isolated cortical vein thrombosis (ICoVT) is a rare form of cerebral venous thrombosis and is easily misdiagnosed as brain tumor due to its atypical clinical presentations and radiological findings similar to brain tumors. The present study focused on 4 patients with ICoVT, 2 men and 2 women. In the 2 male patients, t...

journal_title：Oncology letters

authors： Yu Y,Ren M,Yao S,Zhao X,Qi X

更新日期：2016-01-01 00:00:00

abstract：:No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with a...

journal_title：Oncology letters

authors： Ye B,Li W,Feng J,Shi JX,Chen Y,Han BH

更新日期：2013-05-01 00:00:00

abstract：:Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Altho...

journal_title：Oncology letters

authors： Bascones-Martínez A,Cok S,Bascones-Ilundáin C,Arias-Herrera S,Gomez-Font R,Bascones-Ilundáin J

更新日期：2012-02-01 00:00:00

abstract：:Hypermethylated in cancer 1 (HIC1) is a putative suppressor gene, cooperating with TP53 in the regulation of apoptosis. The promoter site of this gene contains CpG islands susceptible to methylation. Altered methylation leads to the silencing of HIC1. Persistent loss of HIC1 function reflects the attenuation of proapo...

journal_title：Oncology letters

authors： Markowski J,Sieroń AL,Kasperczyk K,Ciupińska-Kajor M,Auguściak-Duma A,Likus W

更新日期：2015-05-01 00:00:00

abstract：:The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...

journal_title：Oncology letters

authors： Qiu S,Xu Y,Huang L,Zheng W,Huang C,Huang S,Lin J,Lin D,Feng S,Chen R,Pan J

更新日期：2016-01-01 00:00:00

abstract：:Gastric cancer is a pathological process of an accumulation of multigene and multistage mutations. A new gene segment, MDSCBC11, has been previously obtained using a gene chip and is negatively associated with gastric cancer. The present study aimed to clone the full cDNA sequence of the MDSCBC11 segment and to detect...

journal_title：Oncology letters

authors： Gan R,Liu X,Zhou Y,Tan Y,Liu H,Li G,Tang Y,Xie H

更新日期：2013-12-01 00:00:00

abstract：:Cancer immunotherapies are designed to elicit T-cell responses that inhibit tumor growth. Previous studies have demonstrated that interleukin 21 (IL-21) is a promising cytokine for cancer immunotherapy due to its ability to induce the immunity of T cells and natural killer cells, whereas blockade of the interaction of...

journal_title：Oncology letters

authors： Pan XC,Li L,Mao JJ,Yao W,Zheng JN,Liu M,Fu JJ

更新日期：2013-01-01 00:00:00

abstract：:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

journal_title：Oncology letters

authors： Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

更新日期：2012-10-01 00:00:00

abstract：:CD133+ tumor cells have a greater potential ability for tumorigenesis, proliferation, invasion and metastasis compared with CD133- tumor cells. Ki-67 is associated with cell proliferation in various tumors and has a markedly positive correlation with the prognosis of patients. However, there are a limited number of st...

journal_title：Oncology letters

authors： Lu C,Liu L,Wu X,Xu W

更新日期：2013-11-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00

abstract：:Pulmonary benign metastasizing leiomyoma (BML) is a rare event characterized by benign soft-tissue tumors that occur when uterine leiomyomas metastasize to the lung. The present study reports the case of a 47-year-old female patient who presented with multiple bilateral pulmonary nodules on a chest X-ray during a heal...

journal_title：Oncology letters

authors： Wei WT,Chen PC

更新日期：2015-07-01 00:00:00