Abstract:
:It has previously been reported that KU60019, as a highly effective radiosensitizer, inhibits the DNA damage response and blocks radiation-induced phosphorylation of key ataxia telangiectasia mutated targets in human glioma cells. The present study investigated whether KU60019 affects cell physiological activities and strengthens the efficacy of doxorubicin-induced DNA damage. It was demonstrated that the compound suppressed the proliferation of MCF-7 cells and significantly increased chemosensitization. In addition, KU60019 (without doxorubicin) inhibited MCF-7 cell motility and invasion, potentially by acting on the phosphorylated-Akt and E-cadherin signaling pathways. Although the majority of MCF-7 cells were arrested at the G1/S phase following treatment with KU60019, the combination of the two compounds did not result in such a marked effect on the cell cycle. In conclusion, KU60019 is a potent chemosensitizer in combination with doxorubicin, therefore, it may provide a promising strategy for non-invasive breast cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhu Y,Mao C,Wu J,Li S,Ma R,Cao H,Ji M,Jing C,Tang Jdoi
10.3892/ol.2014.2444subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2043-2048issue
5eissn
1792-1074issn
1792-1082pii
ol-08-05-2043journal_volume
8pub_type
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