Abstract:
:Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic marker for patients at a high risk of developing OTSCC. The present study used four original microarray datasets to identify the key candidate genes involved in OTSCC pathogenesis. Expression profiles of 93 OTSCC tissues and 76 normal tissues from GSE9844, GSE13601, GSE31056 and GSE75538 datasets were investigated. Differentially expressed genes (DEGs) were determined, and gene ontology enrichment and gene interactions were analyzed. The four GSE datasets reported five upregulated and six downregulated DEGs. Five upregulated genes (matrix metalloproteinase 1, 3, 10 and 12 and laminin subunit gamma 2) were localized in the extracellular region of cells and were associated with extracellular matrix disassembly. Furthermore, analysis for The Cancer Genome Atlas database revealed that the aforementioned five upregulated genes were also highly expressed in OTSCC and head and neck squamous cell carcinoma tissues. These results demonstrated that the five upregulated genes may be considered as potential prognostic biomarkers of OTSCC and may serve at understanding OTSCC progression. Upregulated DEGs may therefore represent valuable therapeutic targets to prevent or control OTSCC pathogenesis.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhong P,Liu L,Shen A,Chen Z,Hu X,Cai Y,Lin J,Wang B,Li J,Chen Y,Peng Jdoi
10.3892/ol.2019.10982subject
Has Abstractpub_date
2019-12-01 00:00:00pages
5959-5967issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-10982journal_volume
18pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6473
更新日期:2017-09-01 00:00:00
abstract::Notch signaling is well-known for its role in regulating cell self-renewal and differentiation. Within the cancer research field, it has been identified that dysregulated Notch signaling is involved directly with various types of cancer. Although Notch signaling is generally considered as oncogenic, it sometimes acts ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10170
更新日期:2019-06-01 00:00:00
abstract::Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6926
更新日期:2017-11-01 00:00:00
abstract::Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11721
更新日期:2020-08-01 00:00:00
abstract::Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4606
更新日期:2016-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12091
更新日期:2020-11-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::Breast cancer is a leading cause of cancer-associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in host cell entry. The ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8344
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to obtain comprehensive microRNA (miRNA) profiles of type I [Ishikawa (ISK)] and type II (HEC-1B) human endometrial adenocarcinoma cell lines, utilizing the latest high-throughput sequencing techniques. RNA was extracted from ISK and HEC-1B cell lines. Sequencing results were obtained ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3776
更新日期:2015-12-01 00:00:00
abstract::Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11423
更新日期:2020-04-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10589
更新日期:2019-09-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6467
更新日期:2017-08-01 00:00:00
abstract::The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8048
更新日期:2018-04-01 00:00:00
abstract::In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2387
更新日期:2014-10-01 00:00:00
abstract::Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12224
更新日期:2020-12-01 00:00:00
abstract::Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4492
更新日期:2016-06-01 00:00:00
abstract::Osteosarcoma is known as a malignant tumour with a high mortality rate in orthopaedic settings; however, the factors associated with its degree of malignancy and the biological response remains to be elucidated. Although the essential role of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been recen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7463
更新日期:2018-02-01 00:00:00
abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.644
更新日期:2012-06-01 00:00:00
abstract::Breast cancer is one of the most prevalent types of cancer in women and contributes to 32% of all female cancer cases. Cathepsins, a family of proteins, are known to have a critical role in human cancers. However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3960
更新日期:2016-01-01 00:00:00
abstract::We investigated the possible association between DLKI gene promoter region methylation and the increased invasion capacity of non-small cell lung cancer (NSCLC). Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells....
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2017.6019
更新日期:2017-06-01 00:00:00
abstract::We investigated whether treatment package time was significantly associated with survival outcomes of resectable locally-advanced laryngeal squamous cell carcinoma in patients who consecutively underwent various treatments, including surgery alone and salvage surgery for residual tumor. A total of 100 patients with cl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9664
更新日期:2019-01-01 00:00:00
abstract::ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10454
更新日期:2019-08-01 00:00:00
abstract::The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9270
更新日期:2018-10-01 00:00:00
abstract::In the present study, we analyzed the supra-additive effect of oxaliplatin in combination with gemcitabine on terminal colorectal cancer and its influence on high-mobility group box 1 (HMGB1) expression. A total of 86 patients with terminal colorectal cancer were enrolled in this study. Patients received oxaliplatin i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5053
更新日期:2016-11-01 00:00:00
abstract::The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2494
更新日期:2014-11-01 00:00:00
abstract::Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjacent tissues from pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11666
更新日期:2020-08-01 00:00:00
abstract::Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11115
更新日期:2020-01-01 00:00:00
abstract::Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11293
更新日期:2020-03-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11071
更新日期:2020-01-01 00:00:00