High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma.

abstract：:The detection of epidermal growth factor receptor (EGFR) mutations is necessary for the selection of suitable patients with non-small cell lung cancer (NSCLC) for treatment with EGFR tyrosine kinase inhibitors. Cytology specimens are known to be suitable for EGFR mutation detection, although tissue specimens should be...

journal_title：Oncology letters

authors： Asaka S,Yoshizawa A,Nakata R,Negishi T,Yamamoto H,Shiina T,Shigeto S,Matsuda K,Kobayashi Y,Honda T

更新日期：2018-02-01 00:00:00

abstract：:Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...

journal_title：Oncology letters

authors： Cao C,Zou J,Wu C,Bao Z,Yang H

更新日期：2012-09-01 00:00:00

abstract：:Ecto-5'-nucleotidase [cluster of differentiation (CD)73] has important functions in several types of cancer, however, its expression in squamous cell carcinoma (SCC) remains unknown. The present study was designed to investigate CD73 expression in SCC. CD73 expression was assessed by immunohistochemistry in 113 patien...

journal_title：Oncology letters

authors： Ren ZH,Yuan YX,Ji T,Zhang CP

更新日期：2016-07-01 00:00:00

abstract：:In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade and prognosis, remain unknown. In the present study, the expression of ST3GAL5 and its association with ...

journal_title：Oncology letters

authors： Ouyang S,Liu JH,Ni Z,Ding GF,Wang QZ

更新日期：2020-07-01 00:00:00

abstract：:Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...

journal_title：Oncology letters

authors： Kozawa E,Nishida Y,Nakashima H,Tsukushi S,Toriyama K,Kamei Y,Ishiguro N

更新日期：2012-01-01 00:00:00

abstract：:Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...

journal_title：Oncology letters

authors： Ma R,Zhang G,Wang H,Lv H,Fang F,Kang X

更新日期：2012-12-01 00:00:00

abstract：:Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression ...

journal_title：Oncology letters

authors： Zhang EL,Gu J,Zhang ZY,Dong KS,Liang BY,Huang ZY

更新日期：2017-07-01 00:00:00

abstract：:TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...

journal_title：Oncology letters

authors： Zhao C,He X,Li H,Zhou J,Han X,Wang D,Tian G,Sui F

更新日期：2018-05-01 00:00:00

abstract：:In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...

journal_title：Oncology letters

authors： Nan ML,Wang X,Li HJ,Yu DH,Sun WY,Xu HM,He YF,Zhao QC

更新日期：2019-01-01 00:00:00

abstract：:In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent c...

journal_title：Oncology letters

authors： Imura J,Abe K,Uchida Y,Shibata M,Tsunematsu K,Sathoh M,Miwa S,Nakajima T,Nomoto K,Hayashi S,Tsuneyama K

更新日期：2014-03-01 00:00:00

abstract：:Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell...

journal_title：Oncology letters

authors： Zhang G,Gao X,Zeng H,Li Y,Guo X

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...

journal_title：Oncology letters

authors： Liu J,Wang Y,Tang Y,Luo J,Long Y,Tan S

更新日期：2020-12-01 00:00:00

abstract：:microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...

journal_title：Oncology letters

authors： Nian W,Ao X,Wu Y,Huang Y,Shao J,Wang Y,Chen Z,Chen F,Wang D

更新日期：2013-08-01 00:00:00

abstract：:Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...

journal_title：Oncology letters

authors： Yan B,Hu Y,Ban KHK,Tiang Z,Ng C,Lee J,Tan W,Chiu L,Tan TW,Seah E,Ng CH,Chng WJ,Foo R

更新日期：2017-03-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00

abstract：:Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...

journal_title：Oncology letters

authors： Cheng L,Shi G,Fang C,Li G,Zheng Y,Chen W

更新日期：2019-03-01 00:00:00

abstract：:Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...

journal_title：Oncology letters

authors： Yuan YJ,Zhou P,Xia F,Zhang XB,He SS,Guo DY,Xing YH,Zhao HW

更新日期：2020-10-01 00:00:00

abstract：:Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...

journal_title：Oncology letters

authors： Guan N,Wang R,Feng X,Li C,Guo W

更新日期：2020-09-01 00:00:00

abstract：:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...

journal_title：Oncology letters

authors： Yan Z,Liu G,Liang M,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...

journal_title：Oncology letters

authors： Li J,Xie Y,Wang X,Jiang C,Yuan X,Zhang A,Yang L,Liu C,Zou H,Li F,Hu J

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of the heat shock protein (HSP)90 inhibitor AUY922 on the proliferation and migratory ability of renal cell carcinoma (RCC) cells. The expression of HSP90 was measured in vitro using western blotting and quantitative polymerase chain reaction in the ACHN and ...

journal_title：Oncology letters

authors： Zhu J,Zhu Y,Qi W,Qiu W

更新日期：2015-08-01 00:00:00

abstract：:The present study aimed to conduct a prognosis analysis of Taiwanese patients with metastatic gastrointestinal stromal tumors (GISTs), who are resistant to or were unable to tolerate imatinib or sunitinib, and were subsequently treated with regorafenib. The study considered the survival, potential prognostic factors a...

journal_title：Oncology letters

authors： Hu CH,Yeh CN,Chen JS,Tsai CY,Wang SY,Cheng CT,Yeh TS

更新日期：2020-09-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...

journal_title：Oncology letters

authors： Yu Y,Chen X,Cang S

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...

journal_title：Oncology letters

authors： Zhang S,Ma Y,Jiang J,Dai Z,Gao X,Yin X,Xi W,Min W

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...

journal_title：Oncology letters

authors： Zhang JB,Zhao LR,Cui TX,Chen XW,Yang Q,Zhou YB,Chen ZT,Zhang SX,Sun JG

更新日期：2018-04-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence and mortality rates are increasing worldwide. Mortalin is a highly conserved chaperone protein involved in multiple pathological and physiological processes, including anti-apoptosis, carcinogenesis and metastasis. The Bcl-2 famil...

journal_title：Oncology letters

authors： Kang Q,Zou H,Yang X,Cai JB,Liu LX,Xie N,Wang LM,Li YH,Zhang XW

更新日期：2018-02-01 00:00:00

abstract：:Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...

journal_title：Oncology letters

authors： Aziz MY,Omar AR,Subramani T,Yeap SK,Ho WY,Ismail NH,Ahmad S,Alitheen NB

更新日期：2014-05-01 00:00:00

abstract：:[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...

journal_title：Oncology letters

authors： Li L,Mao X,Qin X,Zhou M,Xing H,Dong F,Jiang X,Zhuang W

更新日期：2019-05-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma lo...

journal_title：Oncology letters

authors： Pimentel-Gutiérrez HJ,Bobadilla-Morales L,Barba-Barba CC,Ortega-De-La-Torre C,Sánchez-Zubieta FA,Corona-Rivera JR,González-Quezada BA,Armendáriz-Borunda JS,Silva-Cruz R,Corona-Rivera A

更新日期：2016-11-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00