Abstract:
:In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade and prognosis, remain unknown. In the present study, the expression of ST3GAL5 and its association with clinical outcomes in patients with BC was analyzed using various public bioinformatics databases. The difference in ST3GAL5 expression between BC and healthy bladder tissues was also evaluated using data from the Oncomine database, The Cancer Genome Atlas and Gene Expression Omnibus database. The differences in ST3GAL5 expression between muscle invasive BC (MIBC) and non-muscle invasive BC (NMIBC), and high- and low-grade BC were also analyzed. Furthermore, genes that were positively co-expressed with ST3GAL5 in patients with BC were identified from the intersection between the Oncomine, Gene Expression Profiling Interactive Analysis 2 and UALCAN databases. Enrichment analysis by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Reactome pathway enrichment analyses and a gene-concept network was performed using R package. Gene set enrichment analysis was also performed to assess the signaling pathways influenced by the high and low expression of ST3GAL5 in BC. The results indicated that ST3GAL5 expression was significantly lower in BC tissues compared with normal bladder tissues (P<0.05). Furthermore, ST3GAL5 expression in MIBC and high-grade BC was significantly lower compared with NMIBC and low-grade BC (P<0.05), respectively. The results from Kaplan-Meier survival analysis result demonstrated that ST3GAL5 downregulation was associated with poor survival in patients with BC (P<0.05). Taken together, these findings suggested that ST3GAL5 may be considered as an anti-oncogene in BC, could represent a potential predictive and prognostic biomarker for BC and may be a molecular target for tumor therapy.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ouyang S,Liu JH,Ni Z,Ding GF,Wang QZdoi
10.3892/ol.2020.11597subject
Has Abstractpub_date
2020-07-01 00:00:00pages
828-840issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-11597journal_volume
20pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Thyroid carcinoma is the most prevalent endocrine neoplasm globally. In the majority of thyroid carcinoma cases, a positive prognosis is predicted following administration of the appropriate treatment. A wide range of genetic alterations present in thyroid carcinoma exert their oncogenic actions partially through the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4298
更新日期:2016-04-01 00:00:00
abstract::Lung cancer is the most frequent cause of cancer-associated mortality among men and women globally. The skeleton is one of the most common metastatic sites. The majority of patients exhibiting bone metastases are treated using systemic therapy or symptom-based palliative approaches without surgery. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4190
更新日期:2016-03-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2017.5668.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,已发布勘误
doi:10.3892/ol.2017.6875
更新日期:2017-11-01 00:00:00
abstract::DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.992
更新日期:2013-01-01 00:00:00
abstract::Recommendations concerning the intake of vitamin D and/or sunlight exposure in the handling of patients with vitamin D deficiency remain a matter of debate. The present study of the German network of dermato-oncologists (Onkoderm e.V.) refers to an inquiry conducted among general practitioners on this and related issu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.939
更新日期:2012-12-01 00:00:00
abstract::Sarcomas arise from primitive mesenchymal cells, which are classified, into two main groups: Bone and soft tissue sarcomas. We have searched all-important electronic databases including Google scholar and PubMed for the collection of latest literature pertaining to pediatric sarcomas. Latest literature confirmed that ...
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2017.7467
更新日期:2018-02-01 00:00:00
abstract::The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8084
更新日期:2018-04-01 00:00:00
abstract::Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5669
更新日期:2017-03-01 00:00:00
abstract::The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2971
更新日期:2015-04-01 00:00:00
abstract::Ovarian cancer is the most malignant gynecologic neoplasm in women and has the worst prognosis of all cancer types in women based on the 5-year survival rates. A previous study indicated that mangiferin exerts an anti-neoplastic effect on human ovarian cancer cells by targeting Notch3. Additionally, it has been demons...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9708
更新日期:2019-01-01 00:00:00
abstract::Endometrial cancer (EC) is the most commonly diagnosed gynecological malignancy in Australian women. Notably, its incidence and mortality rate is increasing. Despite this, there are limited treatment options for EC. Galectin-7 regulates tumorigenesis in numerous epithelial cancer types, but the role of galectin-7 has ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9193
更新日期:2018-10-01 00:00:00
abstract::The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3082
更新日期:2015-06-01 00:00:00
abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.900
更新日期:2012-12-01 00:00:00
abstract::MicroRNA-1470 (miR-1470) is overexpressed in esophageal squamous cell carcinoma (ESCC); however, its role and underlying molecular mechanism remain unknown. The aim of the present study was to explore the tumorigenic role and mechanism of miR-1470 overexpression in ESCC. The expression of miR-1470 in ESCC tissues and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7190
更新日期:2017-12-01 00:00:00
abstract::The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6159
更新日期:2017-07-01 00:00:00
abstract::Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to augmentation of AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7556
更新日期:2018-02-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to present the results of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC), and to clarify patient characteristics by investigating patient background factors. A total of 59 patients with EC, who received MPA as fertility-sparing therapy a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.602
更新日期:2012-05-01 00:00:00
abstract::The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000034
更新日期:2010-01-01 00:00:00
abstract::Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10814
更新日期:2019-11-01 00:00:00
abstract::Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10402
更新日期:2019-08-01 00:00:00
abstract::Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11071
更新日期:2020-01-01 00:00:00
abstract::Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis-relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5660
更新日期:2017-03-01 00:00:00
abstract::In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.423
更新日期:2012-01-01 00:00:00
abstract::Some colorectal cancer liver metastases (CLMs) disappear on serial imaging during chemotherapy and the optimal treatment strategy for such lesions remains undetermined. The purpose of this study was to investigate the outcome in disappearing CLMs, as few studies have focused on this topic, with conflicting results. Am...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.842
更新日期:2012-11-01 00:00:00
abstract::The present study investigated the anticancer functions of ursolic acid (UA) and its novel derivatives, with a nitrogen-containing heterocyclic scaffold and the privileged fragment at the C-28 position on apoptosis induction, cell proliferation and cell cycle in human BC lines. UA was chemically modified in the presen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7578
更新日期:2018-02-01 00:00:00
abstract::The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8983
更新日期:2018-09-01 00:00:00
abstract::The development of upper tract urothelial carcinoma (UTUC) has been associated with the ingestion of aristolochic acid (AA) in Chinese herbs. The tumors are more malignant and patients have a worse prognosis in China compared with that in Western countries. Recently, whole-genome and exome sequencing of AA-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12212
更新日期:2020-12-01 00:00:00
abstract::Treatment of cancer often requires the use of adjuvant chemotherapy (ACT). In real clinical practice, numerous patients suffer from severe toxicity and reduced quality of life (QoL). Hence, there is a need to maintain QoL and to reduce therapy toxicity to comply with recommended chemotherapy (CT) regimens. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10868
更新日期:2019-11-01 00:00:00
abstract::Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summari...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7288
更新日期:2018-01-01 00:00:00